University of Groningen
Understanding individual drug response variation
Kroonen, Marjolein
DOI:
10.33612/diss.127010643
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Publication date: 2020
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Citation for published version (APA):
Kroonen, M. (2020). Understanding individual drug response variation: Pharmacokinetic analysis of diabetes trials. University of Groningen. https://doi.org/10.33612/diss.127010643
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Understanding individual
drug response variation
Pharmacokinetic analysis of diabetes trials
Door
Colophon
Financial support for the publication of this thesis by the University of
Groningen, University Medical Center Groningen, Graduate School of Medical Sciences (GSMS), Noord Negentig, Boehringer Ingelheim,
KNMP and Astra Zeneca are gratefully acknowledged. ISBN
ISBN: 978-94-034-2711-9 (Printed version) ISBN: 978-94-034-2712-6 (Digital version) Cover design
M.E.A.M. Kroonen Layout
M.Y.A.M. Kroonen Printed by
Ipskamp Drukkers, Enschede
© 2020, M.Y.A.M. Kroonen, Groningen, the Netherlands
All rights reserved. No part of this publication may be reproduced, copied, modified, stored in a retrieval system, or transmitted in any form without permission of the author.
Understanding individual
drug response variation
Pharmacokinetic analysis of diabetes trials
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit
Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
Woensdag 10 juni 2020 om 11:00 uur
door
Marjolein Yvonne Andrea Maria Kroonen
geboren op 30 oktober 1990
te Ermelo
Promotores
Prof. dr. H.J. Lambers-Heerspink
Prof. dr. D. de Zeeuw
Copromotor
Dr. J. StevensBeoordelingscommissie
Prof. dr. R.O. Day Prof. dr. P. Rossing Prof. dr. S.J.L. Bakker
Paranimfen
Jeroen V. Koomen Nienke M.A. Idzerda
Table of Contents
Chapter 1 Introduction and aims of this thesis 11 Chapter 2 A dosing algorithm for metformin based on
the relationships between exposure and renal clearance of metformin in patients with varying degrees of kidney function
25
Chapter 3 Exposure-response relationships of the sodium-glucose co-transporter 2 inhibitor dapagliflozin for renal risk markers
47
Chapter 4 Population pharmacokinetics and individual UACR exposure-response analysis for Empagliflozin, Linagliptin and Telmisartan in patients with type 2 diabetes
65
Chapter 5 Association between individual cholesterol and proteinuria response and exposure to
atorvastatin or rosuvastatin
91
Chapter 6 Summary and future perspectives 109 Chapter 7 Appendices
Nederlandse samenvatting en toekomstperspectieven Dankwoord
About the author
