University of Groningen
Unraveling molecular signaling in neurodegenerative diseases
Sabogal Guaqueta, Angelica
DOI:
10.33612/diss.111514738
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Sabogal Guaqueta, A. (2020). Unraveling molecular signaling in neurodegenerative diseases: focus on a protective mechanism mediated by linalool. University of Groningen.
https://doi.org/10.33612/diss.111514738
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Unraveling molecular signaling in
neurodegenetive diseases:
Focus on a protective mechanism mediated by
linalool
Unraveling molecular signaling in
neurodegenerative diseases:
Focus on a protective mechanism mediated
by linalool
PhD thesis
to obtain the degree of PhD at the
University of Groningen
on the authority of the
Rector Magnificus prof. C. Wijmenga
and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on
Monday 13 January 2020 at 16.15 hours
by
Angélica María Sabogal Guáqueta
born on 12 October 1987
in Ibagué, Colombia
Angélica María Sabogal Guáqueta
Unraveling molecular signaling in neurodegenetive diseases:
Focus on a protective mechanism mediated by linalool ISBN: 978-94-034-2337-1 (e-book)
ISBN: 978-94-034-2336-4 (print)
Copyright © 2019,Angelica Sabogal Guaqueta
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means - electronic, mechanically, by photocopying, recording or otherwise - without express written permission form the author and, when appropriate, the publisher holding the copyrights of the published articles.
Cover and layout design by Claudia González Arévalo claudia@tangroop.com
Printed by IPSKAMP printing https://www.ipskampprinting.nl
Paranymphs:
Pien Goldsteen
Asmaa Oun
Supervisors
Prof. H.W.G.M. Boddeke
Co-supervisor
Dr. A.M. Dolga
Prof. G.P. Cardona Gomez
Assessment Committee
Prof. M. Schmidt
Prof. U.L.M. Eisel
Prof. C. Culmsee
Chapter 6
Transversal phenomenon in the brain parenchyma ofdementias: Phospholipid profile analysis between CADASIL and Sporadic Alzheimer disease
Submitted
141
Chapter 7
Microglia alterations in neurodegenerative diseases and their modeling with human induced pluripotent stem cell and other platformsManuscript in preparation
171
Chapter 8
Generation and functionality of human microglia-differentiated induced pluripotent stem cellsManuscript in preparation
205
Chapter 9
General discussion, conclusions and perspectives223
Appendix
Summary243
Resumen246
Samenvatting Netherlands248
General abbreviations250
Curriculum Vitae251
List of publications252
Acknowledgments253
Table of content
Chapter 1
General introduction9
Chapter 2
Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer’s miceNeuropharmacology 102 (2016) 111-120. doi: 10.1016/j. neuropharm.2015.11.002
33
Chapter 3
Changes in the hippocampal and peripheral phospholipid profiles are associated with neurodegeneration hallmarks in a long-term global cerebral ischemia model: Attenuation by LinaloolNeuropharmacology 135 (2018) 555-571. doi: 10.1016/j. neuropharm.2018.04.015
53
Chapter 4
Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate damageBiomedicine & Pharmacotherapy 118 (2019) 1-12. doi: 10.1016/j. biopha.2019.109295
89
Chapter 5
Inverse Phosphatidylcholine/Phosphatidylinositol Levels as Peripheral Biomarkers and Phosphatidylcholine/ Lysophosphatidylethanolamine-Phosphatidylserine as Hippocampal Indicator of Postischemic Cognitive Impairment in RatsFrontiers in Neuroscience (2018) 1-16. doi: 10.3389/fnins.2018.00989
