• No results found

CCR5 in multiple sclerosis : expression, regulation and modulation by statins

N/A
N/A
Protected

Academic year: 2021

Share "CCR5 in multiple sclerosis : expression, regulation and modulation by statins"

Copied!
5
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)

CCR5 in multiple sclerosis : expression, regulation and modulation by

statins

Kuipers, H.F.

Citation

Kuipers, H. F. (2007, March 28). CCR5 in multiple sclerosis : expression, regulation and modulation by statins. Retrieved from https://hdl.handle.net/1887/11460

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/11460

Note: To cite this publication please use the final published version (if applicable).

(2)

11

Publications

(3)

1 1

(4)

Kuipers HF, Rappert AAC, Mommaas AM, Van Haastert ES, Van der Valk P, Boddeke HWGM, Biber KPH, Van den Elsen PJ. Simvastatin affects cell motility and actin cytoskeleton distribution of microglia. Glia, 2006, 53: 115-123

Kuipers HF and Van den Elsen PJ. Putative immunoregulatory role of statins. Current Immunology Reviews, 2006, 2: 55-64

Immunology Reviews, 2006, 2: 55-64 Immunology Reviews

Kuipers HF, Rappert A, Van Haastert E, Van der Valk P, Boddeke H, Biber K, Van den Elsen PJ. Statins and microglia cell function. Proceedings of VII European Meeting on Glial Cell Functions in Health and Disease, May 17-21, 2005; Amsterdam, The Netherlands.

In: Medimond S.r.l., 2005, 103-107 (ISBN 88-7587-148-5)Medimond S.r.l., 2005, 103-107 (ISBN 88-7587-148-5)Medimond S.r.l.

Kuipers HF, Biesta PJ, Mommaas AM, Groothuis TA, Neefjes JJ, Van den Elsen PJ.

Statins affect cell surface expression of MHC-II molecules by disrupting cholesterol- containing microdomains. Hum. Immunol., 2005, 66: 653-665Hum. Immunol., 2005, 66: 653-665Hum. Immunol.

Kuipers HF and Van den Elsen PJ. Statins and control of MHC2TA transcription. Nature Medicine, 2005, 11: 365-366

Medicine, 2005, 11: 365-366 Medicine

Kuipers HF and Van den Elsen PJ. Regulation and function of immune response genes in the central nervous system. Recent Res. Dev. Immunology, 2004, 6: 243-260 (ISBN: Recent Res. Dev. Immunology, 2004, 6: 243-260 (ISBN: Recent Res. Dev. Immunology 81-7736-206-2)

Van den Elsen PJ, Holling TM, Kuipers HF, Van der Stoep N. Transcriptional regulation of antigen presentation. Curr. Opin. Immunol., 2004, 16: 67-75Curr. Opin. Immunol., 2004, 16: 67-75Curr. Opin. Immunol.

Hulshof S, van Haastert ES, Kuipers HF, van den Elsen PJ, De Groot CJ, van der Valk P, Ravid R, Biber K. CX3CL1 and CX3CR1 expression in human brain tissue:

noninflammatory control versus multiple sclerosis. J. Neuropathol. Exp. Neurol., 2003, J. Neuropathol. Exp. Neurol., 2003, J. Neuropathol. Exp. Neurol.

62: 899-907

Kuipers HF, Biesta PJ, Montagne L, Van Haastert ES, Van der Valk P, Van den Elsen PJ.

CC chemokine receptor 5 (CCR5) gene promoter activation by the cyclic AMP response element binding (CREB) transcription factor. Blood, revised manuscript invitedBlood, revised manuscript invitedBlood

Kuipers HF, Van Haastert ES, Feenstra HM, Van den Elsen PJ, Van der Valk P. Enhanced expression of the chemokine receptor CCR5 in Multiple Sclerosis lesions. Submitted Kuipers HF, Biesta PJ, Van den Elsen PJ. Simvastatin inhibits differentiation of monocytes immature DC and not DC maturation. In preparation

(5)

Referenties

GERELATEERDE DOCUMENTEN

Second, statins block cell surface expression of costimulatory molecules on APC and cell surface First, statins inhibit cell surface expression of MHC-II on APC and so hamper

In preactive lesions however, activated microglia displayed strong CCR5 immunoreactivity and phagocytic macrophages in active demyelinating lesions expressed even higher levels

EMSA showing binding of complexes to the CRE sites located in the CCR5 upstream promoter (CRE-1 through CRE-3) and a CRE consensus probe (cons) EMSA showing binding of complexes

We calculated expression levels after these treatments relative to (A and B) IFN- L-mevalonate (mev) and (C) human activated primary T cells treated with simvastatin or simvastatin

γ (500 U/ml, 48 hours) alone or in combination with simvastatin (10 µM, simva) or simvastatin and L-mevalonate (100 µM, mev). Restaining of blots for actin verified equal γ

Microglial cells were left untreated (filled histograms), or treated with simvastatin analysis of MHC-II and chemokine receptor expression on the cell surface of primary murine (A)

Schemes depicting the different treatment CD86 and HLA-DR on immature monocyte-derived DC (light grey histograms), mature DC (dark grey regimes are presented in Figure 2A.

In addition to the effect of statins on lipid raft integrity, cholesterol depletion by statin treatment may affect not only the composition of cellular membranes and the expression