Cover Page
The handle http://hdl.handle.net/1887/66268 holds various files of this Leiden University
dissertation.
Author: Heijkants, R.C.
Title: Novel functions of MDMX and innovative therapeutic strategies for melanoma
Issue Date: 2018-10-18
Novel functions of MDMX and innovative therapeutic
strategies for melanoma
Renier C. Heijkants
Cover by: Linda van Zijp, StudioLIN.
Lay-out and print by: ProefschriftMaken // www.proefschriftmaken.nl ISBN: -
Copyright 2018 by Renier C. Heijkants, Oss, The Netherlands. All rights reserved.
Copyright of individual chapters lies with the authors, except for chapters 3 and 5.
No part of this thesis may be reproduced, digitalized or transmitted in any form, by any means, electronic or mechanical, including photocopying, recording or by any information storage or retrieval system, without prior permission from the author.
Novel functions of MDMX and innovative therapeutic strategies for melanoma Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op donderdag 18 oktober 2018
klokke 13:45 uur door Renier C. Heijkants geboren te Amersfoort
in 1989
Promotor
Prof. dr. P. ten Dijke Co-promotor Dr. A.G. Jochemsen Promotiecommissie Prof. dr. M.J. Jager
Prof. dr. B.M.T. Burgering (Universitair Medisch Centrum Utrecht) Prof. dr. B.E. Snaar-Jagalska (Universiteit Leiden)
Dr. R. van Doorn
‘Imagine’
John Lennon
9 oktober 1940 – 8 december 1980
Table of contents
Chapter 1 General introduction 9
Chapter 2 MDMX regulates transcriptional activity of p53 and FOXO 37 Chapter 3 Targeting MDMX and PKCδ to improve current uveal melanoma
therapeutic strategies
77
Chapter 4 Combined EZH2 and HDAC inhibition as novel therapeutic intervention for metastasized uveal melanoma
103
Chapter 5 Combined inhibition of CDK and HDAC as a promising therapeutic strategy for both cutaneous and uveal metastatic melanoma
123
Chapter 6 General discussion 153
Appendix Dutch summary 172
Curriculum Vitae 180
List of publications 181
Acknowledgements 183
List of abbreviations 185
