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Cover Page

The following handle holds various files of this Leiden University dissertation:

http://hdl.handle.net/1887/74008

Author: Hogervorst, E.K.

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530970-L-bw-Hogervorst 530970-L-bw-Hogervorst 530970-L-bw-Hogervorst 530970-L-bw-Hogervorst Processed on: 3-5-2019 Processed on: 3-5-2019 Processed on: 3-5-2019

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Blood transfusion in cardiac surgery:

Primum non nocere

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530970-L-bw-Hogervorst 530970-L-bw-Hogervorst 530970-L-bw-Hogervorst 530970-L-bw-Hogervorst Processed on: 3-5-2019 Processed on: 3-5-2019 Processed on: 3-5-2019

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The work described in this thesis was performed at the Center of Clinical Transfusion Research, Leiden.

Financial support by Sanquin and Chipsoft for the publication of this thesis is gratefully acknowledged.

Layout Bianca Pijl, www.pijlldesign.nl, Groningen, The Netherlands Cover design Bianca Pijl (drawing by Akis Ponti) Printed by Ipskamp Printing

Enschede, The Netherlands ISBN 978-94-028-1496-5

© Copyright 2019. Esther Haspels-Hogervorst, Groningen

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530970-L-bw-Hogervorst 530970-L-bw-Hogervorst 530970-L-bw-Hogervorst 530970-L-bw-Hogervorst Processed on: 3-5-2019 Processed on: 3-5-2019 Processed on: 3-5-2019

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Blood transfusion in cardiac surgery:

Primum non nocere

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,

volgens besluit van het College voor Promoties te verdedigen op dinsdag 4 juni 2019

klokke 13.45 uur

door

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530970-L-bw-Hogervorst 530970-L-bw-Hogervorst 530970-L-bw-Hogervorst 530970-L-bw-Hogervorst Processed on: 3-5-2019 Processed on: 3-5-2019 Processed on: 3-5-2019

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Promotor

Prof. dr. J.G. van der Bom Prof. dr. A. Brand

Copromotor

Dr. L.M.G. van de Watering

Promotiecommissie

Prof. dr. R.J.M. Klautz

Prof. T.W.L. Scheeren (UMC Groningen)

Dr. A.W.M.M. Koopman-van Gemert (Albert Schweitzer ziekenhuis) Dr. J.C.C. van der Horst (UMC Groningen)

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530970-L-bw-Hogervorst 530970-L-bw-Hogervorst 530970-L-bw-Hogervorst 530970-L-bw-Hogervorst Processed on: 3-5-2019 Processed on: 3-5-2019 Processed on: 3-5-2019

Processed on: 3-5-2019 PDF page: 5PDF page: 5PDF page: 5PDF page: 5 5 Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8 Chapter 9 Table of contents General Introduction

Prospective validation of the EuroSCORE II risk model in a single Dutch cardiac surgery center (Neth heart J 2018)

Tolerance of intraoperative hemoglobin decrease during cardiac surgery (Transfusion 2014)

Intraoperative anemia and single red blood cell transfusion during cardiac surgery: An assessment of postoperative outcome including patients refusing blood transfusion (J Cardiothoracic Vasc Anesth 2016) Anti-K formation is not associated with the storage time of transfused red blood cells (Transfusion 2015)

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