Dulk, B. den
Citation
Dulk, B. den. (2008, December 2). New factors in nucleotide excision repair : a study in saccharomyces cerevisiae. Retrieved from https://hdl.handle.net/1887/13304
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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New factors in Nucleotide Excision Repair
A study in Saccharomyces cerevisiae
Ben den Dulk
New factors in Nucleotide Excision Repair
A study in Saccharomyces cerevisia e
PProefschrift
Ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties Te verdedigen op dinsdag 2 december 2008
klokke 10:00 uur door Ben den Dulk
Geboren te Den Haag in 1975
promotor : Prof. dr. J. Brouwer co-promotor : Dr. J.A. Brandsma referent : Dr. W. Vermeulen
overige leden: Prof. dr. L.H.F. Mullenders Prof. dr. M.H.M. Noteborn Dr. S.H. Reed
Contents
1 General introduction and scope of the thesis 7
2 Nucleotide excision repair 15
3 Damage recognition by NER 43
4 The Rad4 homologue YDR314C is essential for strand-specific repair of RNA polymerase I-transcribed rDNA in SSaccharomyces
cerevisiae 73
4.1 Supplement: Further analysis of the two Rad4 homologues in
Saccharomyces cerevisiae 91
5 Rad33, a new factor involved in nucleotide excision repair in
Saccharomyces cerevisiae 109
6 The NER protein Rad33 shows functional homology to human Centrin2 and is involved in modification of Rad4 129
7 Summary and concluding remarks 153
Samenvatting 159
Curriculum vitae 163
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