Gangliosides and anti-ganglioside antibodies in neuromuscular synaptic function

In a novel in vivo mouse model of MFS generated through intraperitoneal injection of anti-GQ1b antibody and normal human serum, mice developed respiratory paralysis due

Mouse hemi-diaphragm preparations were treated with anti- GQ1b antibody and normal human serum as a source of complement with added rEV576 or control protein.. Immunohistology

Activity against single gangliosides was less of a problem in the GM1/GQ1b group where 2 of the 6 monospecific anti- ganglioside complex sera induced effects at wildtype NMJs and

Using human and mouse monoclonal anti-GM1 antibodies to probe the GM1-rich motor nerve terminal membrane in mice, we here show that the antigenic oligosaccharide of GM1 in the

It was also shown that the gangliosides are especially enriched in presynaptic membranes (Hansson et al., 1977; Ledeen et al., 1993) and pathophysiological effects on

Molecular mimicry between gangliosides and lipopolysaccharides of Campylobacter jejuni isolated from patients with Guillain-Barré syndrome and Miller Fisher syndrome..

Omdat deze experimenten uitgevoerd werden in relatief jonge muizen (jonger dan drie maanden) en gangliosiden mogelijk niet zozeer een rol spelen in de vroege (embryonale

Greenshields K, Halstead SK, Zitman FMP, Rinaldi S, Brennan KM, O’Leary C, Chamberlain LH, Easton A, Roxburgh J, Pediani J, Furukawa K, Furukawa K, Goodyear CS, Plomp JJ, and