Intervention in hepatic lipid metabolism : implications for atherosclerosis progression and regression
Li, Z.
Citation
Li, Z. (2011, September 27). Intervention in hepatic lipid metabolism : implications for atherosclerosis progression and regression. Retrieved from
https://hdl.handle.net/1887/17872
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/17872
Note: To cite this publication please use the final published version (if applicable).
Intervention in Hepatic Lipid Metabolism:
Implications for Atherosclerosis Progression and Regression
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus Prof. Mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op dinsdag 27 september 2011 klokke 11.15 uur
door
Zhaosha Li
geboren te Changsha, China
in 1983
PROMOTIECOMMISSIE
Promotor: Prof. Dr. Th.J.C. van Berkel Co-promotor: Dr. M. Hoekstra
Overige leden: Prof.Dr.M.Danhof (LACDR, Leiden University) Prof.Dr.A.IJzerman (LACDR, Leiden University)
Dr.M.Smit (MSD Oss)
Prof.Dr.B. Staels (Université Lille Nord de France)
The studies presented in this thesis were supported by Top Institute Pharma (TI Pharma) project T2-110-1 and were performed at the Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
Time will tell.
To my parents
For my love Tristan
Intervention in Hepatic Lipid Metabolism: Implications for Atherosclerosis Progression and Regression
Author: Zhaosha Li
Lay-out: Zhaosha Li
Cover design: Mai Chen; Zhaosha Li Venetian mask
Print: Wöhrmann Print Service
ISBN: 978-90-8570-855-1
Academic thesis, Leiden University, Leiden, The Netherlands
© Z. Li, Leiden 2011
All rights reserved. No part of this publication may be reproduced, stored, or transmitted in any form or by any means, without permission of the author.
Printing of this thesis was financially supported by:
- LACDR
- Leiden University
TABLE OF CONTENTS
Page
Chapter 1 General introduction 8
Chapter 2 Gene Expression Profiling of Nuclear Receptors in Mouse Liver Parenchymal, Endothelial, and Kupffer Cells
Submitted for publication
30
Chapter 3 The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status
J Hepatol. 2010;52:244-251
44
Chapter 4 Niacin reduces plasma CETP levels by diminishing liver macrophage content in CETP transgenic mice Submitted for publication
60
Chapter 5 Effects of pyrazole partial agonists on HCA2- mediated flushing and hepatic VLDL production in mice
Submitted for publication
74
Chapter 6 LXR activation is essential to induce atherosclerotic plaque regression in C57BL/6 mice
Submitted for publication
88
Chapter 7 Bone marrow reconstitution in ApoE–/– mice: a novel model to induce atherosclerotic plaque regression
104
Chapter 8 General discussion and perspectives 124 Chapter 9 English summary
Nederlandse samenvatting List of abbreviations List of publications Curriculum vitae
134 137 140 142 144
