Medication
related
osteonecrosis
of the jaws
(MRONJ)
Diagnosis and treatment
Colofon
Financial support and distribution of this thesis by
Afdeling Mondziekten, Kaak- en Aangezichtschirurgie Leids Universitair Medisch Centrum (LUMC) Nederlandse Vereniging Mondziekten, Kaak- en Aangezichtschirurgie (NVMKA)
Koninklijke Nederlandse Maatschappij tot bevordering der Tandheelkunde (KNMT) Afdeling Mondziekten, Kaak- en Aangezichtschirurgie Hagaziekenhuis
Mondziekten, Kaak- en Aangezichtschirurgie Kennemer & Meer
Afdeling Mondziekten, Kaak- en Aangezichtschirurgie Haaglanden Medisch Centrum Orfeokliniek Zoetermeer
Tandartspraktijk Oosterheem Zoetermeer Dent-Med Materials Exceldent BV KLS Martin Oldelft Benelux BV Nobel Biocare Straumann Proscan Benelux
Tandtechnisch Maxillofaciaal Laboratorium G van Dijk Wouters Tandtechniek
Dam Medical BV
ISBN: 978-94-6361-405-4
Cover design: S. Pichardo & E. Timmerman
Cover front: artistic impression of 3D CT scan of stage III MRONJ with severe necrotic mandibular corps and excessive subperiosteal bone formation.
Cover back: artistic impression of the same patient 1 year post-operative after removal of entire necrotic mandibular corps. The continuity of the mandible was saved with the remaining sub-periosteal bone.
Layout & printing: Optima Grafische Communicatie, Rotterdam, The Netherlands Copyright © 2020 by Sarina Pichardo
Medication Related Osteonecrosis of the Jaws
(MRONJ)
Diagnosis and treatment
Proefschrift
Ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 22 september 2020
Klokke 16.15 uur
door
Sarina Elizabeth Christine Pichardo
Promotor
Prof.dr. J.P.R. van Merkesteyn Copromotor
Dr. N.M. Appelman-Dijkstra Leden promotiecommissie Prof.dr. R.C.M. Pelger Prof.dr. I.B. Schipper
“All things are possible until they are proved impossible and even the impossible may only be so, as of now.”
Pearl S. Buck, schrijfster en Nobelprijswinnaar Literatuur 1938
contents
Chapter 1 Introduction and aim of the study 11
Part I Diagnosis
Chapter 2 Bisphosphonate related osteonecrosis of the jaws: spontaneous or dental origin?
Pichardo sec and Van Merkesteyn jPr
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 sep;116(3):287-92
29
Chapter 3 Dental Implants as a Risk Factor for Medication Related Osteonecrosis of the Jaws (MRONJ)
Pichardo sec, Van der hee jG, appelman-dijkstra nM, Van Merkesteyn jPr
Br J Oral Maxillofac Surg. 2020 jul 3:s0266-4356(20)30126-1
43
Chapter 4 A comparison of the cone beam computed tomography findings in medication-related osteonecrosis of the jaws related to denosumab versus bisphosphonates: an observational pilot study.
Pichardo sec, ten Broek fw, fiocco M, appelman-dijkstra nM, Van Merkesteyn jPr
Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 sep 26. pii: s2212-4403(19)31496-82019
57
Chapter 5 Denosumab osteonecrosis of the mandible: a new entity? A case report.
Pichardo se, Kuypers scc, Van Merkesteyn jPr
J Craniomaxillofac Surg. 2013 jun;41(4):e65-9
71
Part II Treatment
Chapter 6 Bisphosphonate-related osteonecrosis of the jaws: Cohort study of surgical treatment results in seventy-four stage II/III patients.
Pichardo se, Kuypers scc, Van Merkesteyn jPr
J Craniomaxillofac Surg. 2016 sep;44(9):1216-20
85
Chapter 7 Evaluation of a surgical treatment of denosumab-related osteonecrosis of the jaws.
Pichardo sec and Van Merkesteyn jPr
Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 sep;122(3):272-8.
99
Chapter 8 Treatment of pathologic fractures of the mandible in stage III MRONJ- an observational study
Pichardo sec, ten Broek fw, Van Merkesteyn jPr
J Craniomaxillofac Surg 2018 jun 6. pii: s1010-5182(18)30257-9 [epub ahead of print]
113
Chapter 9 3D analysis of surgical treatment MRONJ
Pichardo sec, fiocco M, appelman-dijkstra nM, Van Merkesteyn jPr in revision J Craniomaxillofac Surg. 2019
127 Chapter 10 ‘Autoreconstruction’ of the Mandible-Report of a Case.
Pichardo se, de roos P, Van Merkesteyn jPr
Dent J (Basel). 2016 apr 13;4(2)
