• No results found

Beyond relief : biomarkers of the anti-inflammatory effect and dose selection of COX inhibitors in early drug development

N/A
N/A
Info
Downloaden
Protected

Academic year: 2021

Share "Beyond relief : biomarkers of the anti-inflammatory effect and dose selection of COX inhibitors in early drug development"

Copied!
2
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Download het nu ( 2 pagina )

Hele tekst

(1)

Beyond relief : biomarkers of the anti-inflammatory effect and dose selection of COX inhibitors in early drug development

Huntjens, D.R.H.

Citation

Huntjens, D. R. H. (2008, November 18). Beyond relief : biomarkers of the anti-inflammatory effect and dose selection of COX inhibitors in early drug development. Retrieved from https://hdl.handle.net/1887/13263

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden Downloaded

from: https://hdl.handle.net/1887/13263

Note: To cite this publication please use the final published version (if applicable).

(2)

Referenties

Download het nu ( PDF - 2 pagina - 2.47 MB )

GERELATEERDE DOCUMENTEN

Beyond relief : biomarkers of the anti-inflammatory effect and dose selection of COX inhibitors in early drug development

In this study, we demonstrate the relevance of such a relationship for COX inhibitors by modelling the effect of naproxen on prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) in

Beyond relief : biomarkers of the anti-inflammatory effect and dose selection of COX inhibitors in early drug development

PGE2 and TXB2 concentrations after drug treatment on day 7 were determined at different time points (between 1.5-4 hours post dose) for the different compounds (figure 9, lower

Beyond relief : biomarkers of the anti-inflammatory effect and dose selection of COX inhibitors in early drug development

In this article, we have investigated the relationship between drug exposure and the effect on two biomarkers of the inflammatory response (PGE2 and TXB2) as well as on hyperalgesia

Beyond relief : biomarkers of the anti-inflammatory effect and dose selection of COX inhibitors in early drug development

Purpose: In the present study we investigate the exposure-response relationships for the inhibition of prostaglandin (PGE2) and thromboxane (TXB2) by fenoprofen in rats and

Beyond relief : biomarkers of the anti-inflammatory effect and dose selection of COX inhibitors in early drug development

The overall goal of the research described in this thesis was to analyse the complex interrelationships between biomarker pharmacodynamics, pharmacokinetics and analgesic efficacy

Beyond relief : biomarkers of the anti-inflammatory effect and dose selection of COX inhibitors in early drug development

In translationeel geneesmiddel onderzoek is de keuze van het diermodel een kritische factor. Een belangrijk criterium in dit verband is de voorspellende waarde van PK-PD correlaties

Beyond relief : biomarkers of the anti-inflammatory effect and dose selection of COX inhibitors in early drug development

Currently, Dymphy Huntjens is employed as senior scientist within the department of Advanced Modeling and Simulation of Johnson & Johnson, Pharmaceutical Research and Development

Beyond relief : biomarkers of the anti-inflammatory effect and dose selection of COX inhibitors in early drug development

In analogie met René Magritte's pijp kan worden gezegd dat voor diermodellen van pijn geldt: ceci n'est pas une response inflammatoire, ceci n'est pas un modèle..