Fitness in chronic heart failure : effects of exercise training and of biventricular pacing
Gademan, M.
Citation
Gademan, M. (2009, June 17). Fitness in chronic heart failure : effects of exercise training and of biventricular pacing.
Retrieved from https://hdl.handle.net/1887/13847
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binnenzijde omslag
FITNESS IN CHRONIC HEART FAILURE:
EFFECTS OF EXERCISE TRAINING AND OF BIVENTRICULAR PACING
FITNESS IN CHRONIC HEART FAILURE:
EFFECTS OF EXERCISE TRAINING AND OF BIVENTRICULAR PACING
MAAIKE G. J. GADEMAN
EXERCISE TRAINING IN CHRONIC HEART FAILURE 3
FITNESS IN CHRONIC HEART FAILURE:
EFFECTS OF EXERCISE TRAINING AND OF BIVENTRICULAR PACING
Proefschrift ter verkrijging van
de graad Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P. F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op woensdag 17 juni 2009 klokke 15.00 uur
door
Maaike Gademan geboren te Utrecht in 1979 Colophon
ISBN: 978-90-9024250-7 Book design and Composition (parenthese:)Weesp Printing E.P.A. van de Geer bv, Badhoevedorp Binding Meeuwis bv, Amsterdam Cover: Eén enkele ademteug, Nol van der Linden & Maaike Gademan,
Weesp, The Netherlands (2009).
The studies described in this thesis were performed at the department of Cardiology, Leiden University Medical Center,
Leiden, The Netherlands
Copyright © 2009 Maaike G. J. Gademan, Leiden, The Netherlands. All rights reserved.
No part of this book may be reproduced or transmitted in any form or by any means, without prior written permission of the author.
Financial support to the costs associated with the publication of this thesis from Astellas Pharma BV, AstraZeneca BV, Biotronik BV, Boston Scientific Nederland BV,
Finapres Medical Systems BV, Medtronic BV, Merck Sharpe & Dohme BV, Mortara Instrument BV, Pfizer BV, Pink Roccade Healthcare BV, and St. Jude Medical Nederland BV
is gratefully acknowledged.
Promotores
Co-promotor Overige Leden
PROMOTIECOMMISSIE Prof. Dr. E. E. van der Wall Prof Dr. M. J. Schalij Dr. Ir. C. A. Swenne Dr. J. Brügemann
(Universitair Medisch Centrum Groningen) Prof. Dr. J. H. Arendzen
(Leids Universitair Medisch Centrum) Dr. J. M. Karemaker
(Academisch Medisch Centrum, Universiteit van Amsterdam)
The research described in this thesis was supported by a grant of the Netherlands Heart Foundation (grant nr. 2003B094).
Financial support by the Netherlands Heart Foundation and JE Jurriaanse stichting for the publication of this thesis is gratefully acknowledged.
‘Enkel met het hart kan men goed zien, het essentiële is onzichtbaar voor de ogen’
(Antoine de Saint-Exupéry)
Aan Jens
CONTENTS
Chapter 1 13
Introduction
1.1 Prevalence and prognosis of
heart failure 14
1.2 Pathophysiology of chronic
heart failure 14
1.3 Fitness 16
1.3.1 Fitness and exercise capacity in CHF 16 1.3.2 Fitness and autonomic functioning
in CHF 18
1.4 Treatment of heart failure 19 1.5 Mechanisms and effects of exercise
training 19
1.6 Effects/mechanisms of biventricular
pacing on fitness 20
1.7 Aims and outline of this thesis 21
Chapter 2 28
Effect of exercise training on autonomic derangement and neurohumoral activation in chronic heart failure.
J Card Fail 2007;13:294-303
Chapter 3 46
Baroreflex sensitivity, blood pressure buffering, and resonance: what are the links? Computer simulation of healthy subjects and heart failure patients.
J Appl Physiol 2007;102:1348-1356
Chapter 4 62
Periodic somatosensory stimulation increases the arterial baroreflex sensitivity in chronic heart failure patients.
Submitted
Chapter 5 72
Exercise training increases oxygen uptake efficiency slope in chronic heart failure.
Eur J Cardiovasc Prev Rehabil 2008;15:140-144
Chapter 6 82
The effect of exercise training on oxygen uptake - work relation in chronic heart failure.
Submitted
Chapter 7 94
Biventricular pacing in chronic heart failure acutely facilitates the arterial baroreflex.
Am J Physiol Heart Circ Physiol 2008;2:755-760
Chapter 8 106
Biventricular pacing-induced acute response in baroreflex sensitivity has predictive value for mid-term response to cardiac resynchronization therapy.
Am J Physiol Heart Circ Physiol 2009;
in press
Chapter 9 119
Summary, Conclusions and Future Perspectives
Samenvatting, Conclusies en Toekomstperspectief List of frequently used
abbreviations 133
List of publications 135
Nawoord 138
Curriculum Vitae 141
