Citation
Boogaardt, D. E. M. van den. (2006, December 7). Towards tolerance inducing strategies in
kidney transplantation. Retrieved from https://hdl.handle.net/1887/5423
Version:
Corrected Publisher’s Version
License:
Licence agreement concerning inclusion of doctoral thesis in the
Institutional Repository of the University of Leiden
Downloaded from:
https://hdl.handle.net/1887/5423
Towards tolerance inducing strategies in kidney
transplantation
Towards tolerance inducing strategies in kidney
transplantation
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus Dr.D.D.Breimer,
hoogleraar in de faculteit der Wiskunde en Natuurwetenschappen en die der Geneeskunde, volgens besluit van het College voor Promoties te verdedigen op donderdag 7 december 2006
klokke 13.45 uur door
Daniëlle Eleonora Maria van den Boogaardt
Referent: Dr. A.R. Bushell
John Radcliffe Hospital, University of Oxford, UK
Overige leden: Prof. Dr. J.W. de Fijter
Prof. Dr. A. Brand
Prof. Dr. W. Weimar, Erasmus MC, Rotterdam
D.E.M. van den Boogaardt, Leiden, The Netherlands.
Towards tolerance inducing strategies in kidney transplantation.
The research described in this thesis was performed at the Department of Immunohematology and Blood Transfusion of the Leiden University Medical Center and was financially supported by the Dutch Kidney Foundation (C00.6011) and the Macropa Foundation.
ISBN-10: 90-8559-216-X ISBN-13: 978-90-8559-216-7
Printed by Optima Grafische Communicatie, Rotterdam, The Netherlands.
Contents
Chapter 1 Introduction 9
Towards tolerance inducing strategies in kidney transplantation.
Chapter 2 The influence of inherited and noninherited parental antigens 27 on outcome after transplantation.
(Transplant International 2006; 19(5): 360-371)
Chapter 3 No in vitro evidence for a decreased alloreactivity towards 51 noninherited maternal HLA antigens in healthy individuals.
(Human Immunology 2005; 66(12):1203-1212)
Chapter 4 No evidence for a specific effect of the noninherited maternal 67 HLA antigens on the cellular alloimmune response in patients with a well functioning graft.
Chapter 5 Prolongation of skin graft survival by modulation of the 81 alloimmune response with alternatively activated dendritic cells.
(Transplantation, 2003; 76(11): 1608-1615)
Chapter 6 Differentially modulated dendritic cells induce different types 99 of regulatory T cells.
(Submitted for publication)
Chapter 7 The ratio of IFN-γ and IL-10 producing donor-specific cells as 121 an in vitro monitoring tool for renal transplant patients.
(Transplantation, 2006; 82(6): 844-848)
Chapter 8 Summary and general discussion 133 Towards tolerance inducing strategies in kidney transplantation.
Chapter 9 Samenvatting 149
Het induceren van tolerantie in niertransplantatie patiënten.
Curriculum vitae 157
