Regulation of osteoblast differentiation Barendsz-van der Horst, Geertje

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Printing of this thesis was financially supported by the Netherlands Organization of Scientific Research (NWO) and the Dutch Society of Calcium and Bone

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In addition, PTHrP might affect the expression or posttranslational modification of the transcription factors RunX2 or osx (respectively arrows 5 and 6 for RunX2 and 7 an 8 for

The presence of BMP signaling pathway components during all phases of differentiation, the specific induction of BMP-8a mRNA during the mineralization phase, and

Addition of recombinant human sonic hedgehog (rhSHh) potently increased osteoblastic differentiation of KS483 cells dose-dependently as determined by a modest increase in ALP

To study the effect of Wnt signaling on more mature stages of osteoblast differentiation, we examined the effects of Wnt/β-catenin signaling on bone nodule formation and

In contrast, treatment of undifferentiated KS483 cells with hPTHrP (1-34) for 72 hours prevented the increase in RunX2 mRNA and protein expression normally observed