Expression and function of nuclear receptor coregulators in brain: understanding the cell-specific effects of glucocorticoids

The ‘consensus GRE’ has been empirically defined and typically is composed of two palindromic hexanucleotide half sites separated by a spacer composed of three arbitrary

In line with our working hypothesis that the modulation of gene transcription by glucocorticoids is dependent on the type and amount of corepressor present, we calculated the relative

The steroid receptor coactivator 1a (SRC1a), SRC-1e, nuclear corepressor (N-CoR) and silencing mediator of the retinoid and thyroid hormone receptor (SMRT) were studied in this

When DEX treatment is started after forskolin stimulation of the CRH promoter, the time- window separating both treatments was of great consequence for the level of repression (fig. A

Lastly, we demonstrate using multiple tissue in situ hybridisation a marked increase in mRNA expression levels in spleen, thymus, heart, lung, liver, muscle, testis, kidney,

For this reason, the distribution of the first two corepressors identified was determined in rodent brain (in chapter 2). In situ hybridization experiments provided proof that

In chapter 3, based on the above mentioned uneven distribution in rodent brain of the corepressors and the previously described SRC1 expression levels, the effect of these

Ten eerste wordt er in hoofdstuk 2 de mate van expressie van de twee eerst ontdekte en functioneel verschillende corepressoren (d.w.z. N-CoR en SMRT) in de hersenen en hypofyse