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Microvascular protection during cardiopulmonary bypass
Dekker, N.A.M.
2021
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citation for published version (APA)
Dekker, N. A. M. (2021). Microvascular protection during cardiopulmonary bypass: Mind the gap.
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TABLE OF CONTENTS
List of abbreviations
Chapter 1 General introduction
PART I - Microcirculatory perfusion disturbances following cardiopulmonary bypass
Chapter 2 Sublingual microcirculatory perfusion disturbances following cardiopulmonary bypass: a systematic review Chapter 3 Postoperative microcirculatory perfusion and endothelial
glycocalyx shedding following cardiac surgery with cardiopulmonary bypass
Chapter 4 Microvascular alterations during cardiac surgery using a heparin or phosphorylcholine-coated circuit
Chapter 5 Microcirculatory perfusion disturbances following cardiac surgery with cardiopulmonary bypass are associated with in vitro endothelial hyperpermeability and increased angiopoietin-2 levels 8 11 33 35 67 87 107
PART II - Reduction of microvascular leakage to protect microcirculatory perfusion following cardiopulmonary bypass
Chapter 6 Pharmacological interventions to reduce edema following cardiopulmonary bypass: a systematic review and meta-analysis
Chapter 7 Vasculotide, an angiopoietin-1 mimetic, reduces pulmonary vascular leakage and preserves microcirculatory perfusion during cardiopulmonary bypass in rats
Chapter 8 Preservation of renal endothelial integrity and reduction of renal edema by aprotinin does not preserve renal perfusion and function following experimental cardiopulmonary bypass
Chapter 9 Discussion and conclusion
Appendices English summary
Nederlandse samenvatting Dankwoord List of publications Biography 129 131 175 199 225 251 257 265 271 275
LIST OF ABBREVIATIONS
ACT Activated clotting time AKI Acute kidney injury Ang Angiopoietin ANOVA Analysis of variance AP Aprotinin
ARRIVE Animal Research: Reporting of In Vivo Experiment bM199 Bare M199 medium
cM199 Complete M199 medium CABG Coronary artery bypass grafting CI Confidence interval
CEUS Contrast enhanced ultrasound CO2 Carbon dioxide
CPB Cardiopulmonary bypass DAPI 4′,6-diamidino-2-phenylindole
ECIS Electric cell-substrate impedance sensing EGF Endothelial growth factor
eGFR Estimated glomerular filtration rate ELISA Enzyme-linked immuno sorbent assay FCD Functional capillary density
HAS Human serum albumin HES Hydroxyethyl starch Hrs Hours
ICAM-1 Intercellular adhesion molecule 1 ICU Intensive care unit
IDF Incidence dark field imaging IFNy Interferon gamma
IL Interleukin
IQR Interquartile range KIM-1 Kidney injury molecule-1 MFI Microvascular flow index Min Minutes
MMP Matrix metalloprotease MPO Anti-myeloperoxidase MSB Martius, scarlet and blue
NIH National Institutes of Health NO Nitric oxide
OPS Orthogonal polarization spectral imaging technique OPCABG Off-pump coronary artery bypass grafting
PAR1 Protease-activated receptor 1 PBS Phosphate buffered solution PEEP Positive end-expiratory pressure PVD Perfused vessel density
PMVEC Pulmonary microvascular endothelial cell PPV Proportion of perfused vessels
PRISMA Preferred Reporting Items for Systematic Reviews and Meta-analyses P-sel P-selectin
ROS Reactive oxygen species
sCR1 Soluble complement receptor type 1 SD Standard deviation
SDF Side-stream dark field imaging SMD Standardized mean difference sTM Soluble thrombomodulin SVD Small vessel density
SYRCLE Systematic Review Centre for Laboratory animal Experimentation TAT Thrombin-antithrombin complex
TF Tissue factor
Tie2 Tyrosine kinase with immunoglobulin-like and EGF-like domains 2 TNFα Tumor necrosis factor alpha
TVD Total vessel density
VCAM Vascular cell adhesion molecule VD Vessel density
VE-cadherin Vascular endothelial cadherin VEGF Vascular endothelial growth factor
VEGFR2 Vascular endothelial growth factor receptor-2 VT Vasculotide
vWF Von Willebrand factor W/D Wet-to-dry
