Cover Page
The handle
http://hdl.handle.net/1887/72514
holds various files of this Leiden University
dissertation.
Author: Spa, S.J.
for applications in theranostics
SUPRAMOLECULAR
HOST-GUEST CHEMISTRY
Supramolecular host-guest chemistry for applications in theranostics © S.J. Spa, 2019
ISBN: 978-94-6380-276-5
Design and lay-out: Wendy Schoneveld || www.wenzid.nl Printed: ProefschiftMaken || Proefschiftmaken.nl
Supramolecular host-guest chemistry
for applications in theranostics
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden op gezag van Rector Magnificus Prof. mr. C. J. J. M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op donderdag 9 mei 2019
klokke 11.15 uur
door
Silvia Johara Spa
Promotor
Prof. Dr. M.A. van Buchem
Co-promotoren
Dr. F.W.B. van Leeuwen Prof. R.C. Hoeben
Leden promotiecommissie
Prof. Dr. J.A. van der Hage Prof. Dr. E. Bouwman
Table of Contents
CHAPTER 1 lntroduction and outline ... 8
CHAPTER 2 Obtaining control of cell surface functionalizations via
Pre-targeting and Supramolecular host guest interactions ... 15
CHAPTER 3 A Supramolecular Approach for Liver Radioembolization ... 71
CHAPTER 4 In vivo stability of supramolecular host-guest complexes
monitored by dual- isotope multiplexing in a pre-targeting model of experimental liver radioembolization ... 99
CHAPTER 5 Orthogonal Functionalization of Ferritin via Supramolecular
Re-Assembly ... 127
CHAPTER 6 The influence of systematic structure alterations on the photophysical properties and conjugation characteristics of
asymmetric cyanine 5 dyes ... 157
CHAPTER 7 Future perspectives ... 193
CHAPTER 8 Summary ... 197
CHAPTER 9 Nederlandse samenvatting ...
