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The handle http://hdl.handle.net/1887/24307 holds various files of this Leiden University dissertation
Author: Broek, Colette van den
Title: Optimisation of colorectal cancer treatment
Issue Date: 2014-02-27
Optimisation of colorectal cancer treatment
Colette van den Broek
Drukwerk
Optima Grafische Communicatie, Rotterdam
2013 Colette van den Broek | Leiden | The Netherlands
Alle rechten voorbehouden. Niets uit deze opgave mag worden verveelvoudigd, opgeslagen in een geautoriseerd gegevensbestand of openbaar gemaakt, in enige vorm of op enige wijze, hetzij elektronisch, mechanisch, door fotokopieën, opnamen of op enige andere wijze, zonder voorafgaande schriftelijke toestemming van de auteur.
All rights reserved. No part of this thesis may be reproduced or transmitted without the prior permission of the author.
ISBN 978-94-6169-468-3
Optimisation of colorectal cancer treatment
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op donderdag 27 februari 2013
klokke 15.00 uur
door
Colette Bernadine Maria-Theresia van den Broek geboren te ’s Hertogenbosch in 1984
PrOmOtiecOmmissie
Promotor
Prof. Dr. C.J.H. van de Velde
Co-promotores Dr. E. Bastiaannet Dr. G.J. Liefers
Beoordelingscommissie Dr. A.J.M. de Craen Prof. Dr. A.J. Gelderblom Prof. Dr. C.A.M. Marijnen
Prof. Dr. H.J.T. Rutten Academisch Ziekenhuis Maastricht Catharina Ziekenhuis Eindhoven
Overige commissieleden
Dr. J.E.A. Portielje Haga Ziekenhuis Den Haag
Prof. Dr. M. Verheij Antoni van Leeuwenhoek Ziekenhuis Amsterdam Vrije Universiteit Amsterdam
cOntents
introduction
1 General introduction and outline of this thesis 9
Part i colorectal cancer; treatment and survival
2 Time trends in chemotherapy (administration and costs) and relative survival in stage III colon cancer patients - a large population-based study from 1990 to 2008 Acta Oncologica
21
3 Adjuvant chemotherapy use in stage III colon cancer patients Submitted for publication
39
4 The survival gap between middle-aged and elderly colon cancer patients. Time trends in treatment and survival
European Journal of Surgical Oncology
57
5 Importance of the first postoperative year in the prognosis of elderly colorectal cancer patients
Annals of Surgical Oncology
75
6 Impact of the interval between short course radiotherapy and surgery on outcomes of rectal cancer patients
European Journal of Cancer
89
Part ii international comparisons in colorectal cancer treatment and survival
7 The EURECCA project: Data items scored by European colorectal cancer audit registries
European Journal of Surgical Oncology
111
8 Differences in preoperative treatment administration of rectal cancer patients between Norway, Sweden, Denmark, Belgium and the Netherlands
Submitted for publication
121
9 A comparison of high dose rate endorectal brachytherapy, short course radio- therapy and chemoradiation on the outcome of rectal cancer patients Submitted for publication
141
Discussion
10. General discussion and future perspectives Summary
Summary in Dutch (Nederlandse samenvatting)
155 167 179
Appendices
List of contributing authors List of publications
Acknowledgements (Dankwoord) Curriculum vitae
189 193 197 199
