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The handle http://hdl.handle.net/1887/47854 holds various files of this Leiden University dissertation

Author: Wilhelmus, S.

Title: Systemic lupus erythematosus: pathogenesis, diagnosis, and treatment

Issue Date: 2017-03-15

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Systemic lupus erythematosus:

pathogenesis, diagnosis, and treatment

Suzanne Wilhelmus

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The printing of this thesis was financially supported by the NVLE, Dutch Arthritis Foundation, The Dutch Kidney Foundation, and Chipsoft

Layout: E. Roos and W.J.V. van Est, Academic Medical Center Amsterdam Cover design: W.J.V. van Est, Academic Medical Center Amsterdam Printed by: Ridderprint BV

ISBN: 978-94-6299-539-0

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Systemic lupus erythematosus:

pathogenesis, diagnosis, and treatment

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus prof. mr. C.J.J.M. Stolker,

volgens besluit van het College voor Promoties te verdedigen op woensdag 15 maart 2017

klokke 10.00 uur

door

Suzanne Wilhelmus geboren te Zoetermeer

in 1982

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Promotiecommissie

Prof. dr. J.H.M. Berden, UMC Nijmegen Prof. dr. R. Goldschmeding, UMC Utrecht Prof. dr. V.T.H.B.M. Smit

Dr. C.J. Peutz-Kootstra, UMC Maastricht

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Contents

Chapter 1 General Introduction 9

Chapter 2 Interobserver Agreement on Histopathological Lesions 35 in Class III or IV Lupus Nephritis

Clinical Journal of the American Society of Nephrology 2015; 10: 47-53

Chapter 3 The Revisited Classification of Glomerulonephritis in Systemic Lupus 51 Erythematosus at 10 years: Time to Re-evaluate

Histopathologic Lesions

Journal of the American Society of Nephrology 2015; 26: 2938-2946

Chapter 4 Lupus Nephritis Management Guidelines Compared 71

Nephrology Dialysis Transplantation 2016; 31: 904-913

Chapter 5 Increased Microchimerism in Peripheral Blood of Women 109 with Systemic Lupus Erythematosus

Chapter 6 Microchimerism in Peripheral Blood of Patients with Systemic 125 Lupus Erythematosus during and after Pregnancy

Chapter 7 Familial and Sporadic Lupus Nephritis Compared: 139 Genetics, Clinical Characteristics, Histology, and Renal Outcome

Chapter 8 Summary and Discussion 155

Addenda Nederlandse Samenvatting 175

Curriculum Vitae 181

List of Publications 183

Dankwoord 185

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