Towards restoring the physiological protection against airway narrowing in asthma : take a deep breath! Slats, A.M.

Citation

Slats, A. M. (2011, December 15). Towards restoring the physiological protection against airway narrowing in asthma : take a deep breath!.

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Towards restoring the physiological protection against airway narrowing in asthma

Take a deep breath!

Annelies Slats

Omslag: dragonfl y and lotusfl owers, A.M.Slats

Lay-out en drukwerk: Optima Grafi sche Communicatie, Rotterdam, Nederland

De druk van dit proefschrift werd gedeeltelijk fi nancieel ondersteund door:

Chiesi, Nycomed B.V., Novartis Pharma B.V. en GlaxoSmithKline

Annelies BW.indd 2

Annelies BW.indd 2 24-Oct-11 13:38:05 PM24-Oct-11 13:38:05 PM

Towards restoring the physiological protection against airway narrowing in asthma

Take a deep breath!

PROEFSCHRIFT

ter verkrijging van

de graad Doctor aan de Universiteit leiden

op gezag van de Rector Magnifi cus Prof. Mr. P.F. van der Heijden,

volgens besluit van het College van Promoties te verdedigen op donderdag 15 december 2011

klokke 13.45 uur

door

Annelies Margaretha Slats

geboren te Apeldoorn

in 1978

Overige leden:

Prof. dr. P.S. Hiemstra

Prof. dr. J.C. de Jongste (Erasmus Medisch Centrum Rotterdam, Sophia kinderziekenhuis) Prof. dr. E.H.D. Bel (Academisch Medisch Centrum, Universiteit van Amsterdam)

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Contents

Chapter 1 Introduction 7

Chapter 2 Bronchial infl ammation and airway responses to deep inspiration in asthma and chronic obstructive pulmonary disease

Am J Respir Crit Care Med 2007; 176 (2): 121-128

37

Chapter 3 Expression of smooth muscle and extracellular matrix proteins in relation to airway function in asthma

J Allergy Clin Immunol, 2008; 121 (5): 1196-1202

55

Chapter 4 Infl uence of pulmonary congestion in mitral valve disease on airway responses to deep inspiration.

Submitted for publication

71

Chapter 5 Improvement in bronchodilation following deep inspiration after a course of high-dose oral prednisone in asthma

Chest 2006; 130 (1): 58-65

87

Chapter 6 Treatment with tiotropium improves airways obstruction, but not airway hyperresponsiveness, in asthma

Submitted for publication

105

Chapter 7 Enhanced airway dilation by positive-pressure infl ation of the lungs compared with active deep inspiration in patients with asthma J Appl Physiol 2008; 105: 1725-1732

123

Chapter 8 Fluctuations and determinism of respiratory impedance in asthma and chronic obstructive pulmonary disease

J Appl Physiol 2010; 109 (6): 1582-1591

143

Chapter 9 Summary and general discussion 167

Chapter 10 Nederlandse samenvatting en discussie 185

Curriculum Vitae 201

Dankwoord 203

Publicaties 205