Clinical and molecular aspects of MUTYH- and APC-associated polyposis Nielsen, M.

We present our evaluation results in the terms of "additional cost per QALY", making this a cost-utility analysis (CUA). The model estimates effectiveness and cost

The following terms were employed as search terms: colon carcinomas, bowel cancer, CRC, sporadic, MSI-high, Lynch, HNPCC, histological, molecular, APC, KRAS2, p53,

For example, chromosomes 17p and 18q are commonly affected by physical loss in sporadic colorectal cancer, whereas cnLOH is identified primarily on these chromosome arms in

The aim of this study was to explore the feasibility of identifying patients with (atypical) MAP using KRAS2 c.34G>T somatic prescreening followed by MUTYH hotspot analysis in

In this retrospective multicenter cohort study from Europe, 147 patients with MUTYH- associated polyposis colorectal cancer were compared with 272 population-based

9 We investigated whether the loss of any of these molecules was coupled to HLA class I expression deficiencies in MAP carcinomas; expression of β2m was absent in 58% of MAP

The relative mild clinical phenotype of patient IV.9, who is compound heterozygous for MUTYH [Tyr165Cys] and [Gly382Asp] and also carrying the MSH6 germline mutation might be

at the MUTYH, OGG1, NEIL1, NEIL2, NEIL3, NUDT1 and NTH1 loci in 167 patients who had a phenotype of multiple CRAs resembling FAP or AFAP but in whom no truncating mutations in APC