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University of Groningen

Fitness to drive of older drivers with cognitive impairments

Piersma, Dafne

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

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Publication date:

2018

Link to publication in University of Groningen/UMCG research database

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Piersma, D. (2018). Fitness to drive of older drivers with cognitive impairments. Rijksuniversiteit Groningen.

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alternative transportation for patients with cognitive impairment should be

studied, e.g. of taxi services and cycling.

Additionally, there should be more research on rehabilitation-oriented

assessments of fitness to drive to reveal options to compensate for cognitive

impairments. Fitness-to-drive assessments provide information about

individuals’ weaknesses for which they may require in-car support, education

or training as well as strengths that could be used in rehabilitation. As an

example, for some patients with wayfinding difficulties, driving with a

navigation system might facilitate a prolonged duration of driving

continuation. In this context, the development of technological innovations, in

particular (partially) automated vehicles is very promising. Current highly

automated vehicles, however, may not be suitable for patients who are unfit to

drive as the driver needs to intervene when unexpected situations occur or in

case of road works (Aeberhard et al., 2015), i.e. in traffic situations in which

patients with cognitive impairment need support, they would have to drive

themselves. Nonetheless, if cars become fully automated, there is no need of a

driver anymore, therefore, patients with cognitive impairment who are no

longer fit to drive may be allowed to travel in fully automated cars in the

future. Although this idea is very attractive, there are many hurdles to take

before all traffic will become fully automated (Aeberhard et al., 2015;

Kyriakidis, Happee, & de Winter, 2015).

7.11.

Conclusions

This thesis addresses how fitness to drive should be assessed in patients with

different aetiologies of cognitive impairment. This topic is very relevant as

patients with cognitive impairment are at risk for unsafe driving, but a large

proportion of them are fit to drive in early stages of their disease warranting

individual evaluations. A fitness-to-drive assessment including clinical

interviews, neuropsychological tests, and driving simulator rides is a

promising approach for patients with AD. Additionally, for patients with

different types of dementia (e.g. vascular dementia, frontotemporal dementia,

Lewy body dementia) different assessment strategies must be developed to

evaluate their fitness to drive. Driving recommendations given after

fitness-to-drive assessments were effectively promoting driving continuation of patients

who were fit to drive and driving cessation of patients who were no longer fit

to drive. In the process of driving cessation, patients with cognitive

impairment may need support to stimulate the transition to alternative

transportation, in order to retain mobility and social participation.

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Andrew, C., Traynor, V., & Iverson, D. (2015). An integrative review: understanding driving retirement decisions for individuals living with a dementia. Journal of Advanced Nursing, 71(12), 2728–2740. http://doi.org/10.1111/jan.12727

Anstey, K. J., Windsor, T. D., Luszcz, M. A., & Andrews, G. R. (2006). Predicting Driving Cessation over 5 Years in Older Adults: Psychological Well-Being and Cognitive Competence Are Stronger Predictors than Physical Health. Journal of the American Geriatrics Society, 54(1), 121–126. http://doi.org/10.1111/j.1532-5415.2005.00471.x Bacon, D., Fisher, R. S., Morris, J. C., Rizzo, M., & Spanaki, M. V. (2007). American Academy

of Neurology position statement on physician reporting of medical conditions that may affect driving competence. Neurology, 68(15), 1174–7.

http://doi.org/10.1212/01.wnl.0000259514.85579.e0

Ball, K., & Owsley, C. (2003). Driving Competence: It’s Not a Matter of Age. Journal of the American Geriatrics Society, 51(10), 1499–1501. http://doi.org/10.1046/j.1532-5415.2003.51487.x

Ball, K., Owsley, C., Sloane, M. E., Roenker, D. L., & Bruni, J. R. (1993). Visual attention problems as a predictor of vehicle crashes in older drivers. Investigative Ophthalmology & Visual Science, 34(11), 3110–23.

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to Drive in Dementia: A Systematic Review. Journal of the American Geriatrics Society, 64(9), 1904–1917. http://doi.org/10.1111/jgs.14180

Berg-Weger, M., Meuser, T. M., & Stowe, J. (2013). Addressing Individual Differences in Mobility Transition Counseling With Older Adults. Journal of Gerontological Social Work, 56(3), 201–218. http://doi.org/10.1080/01634372.2013.764374

Berndt, A., Clark, M., & May, E. (2008). Dementia severity and on-road assessment: Briefly revisited. Australasian Journal on Ageing, 27(3), 157–160. http://doi.org/10.1111/j.1741-6612.2008.00300.x

Betz, M. E., Scott, K., Jones, J., & Diguiseppi, C. (2016). “Are you still driving?” Metasynthesis of patient preferences for communication with health care providers. Traffic Injury Prevention, 17(4), 367–373. http://doi.org/10.1080/15389588.2015.1101078

Bixby, K., Davis, J. D., & Ott, B. R. (2015). Comparing Caregiver and Clinician Predictions of Fitness to Drive in People With Alzheimer?s Disease. American Journal of Occupational Therapy, 69(3), 6903270030p1-6903270030p7. http://doi.org/10.5014/ajot.2015.013631

Bleeker, S., Moll, H., Steyerberg, E., Donders, A., Derksen-Lubsen. G, Grobbee, D., & Moons, K. (2003). External validation is necessary in prediction research:: A clinical example. Journal of Clinical Epidemiology, 56(9), 826–832. http://doi.org/10.1016/S0895-4356(03)00207-5

Boeve, B. F. (2011). The Multiple Phenotypes of Corticobasal Syndrome and Corticobasal Degeneration: Implications for Further Study. Journal of Molecular Neuroscience, 45(3), 350–353. http://doi.org/10.1007/s12031-011-9624-1

Boot, W. R., Stothart, C., & Charness, N. (2014). Improving the Safety of Aging Road Users: A Mini-Review. Gerontology, 60(1), 90–96. http://doi.org/10.1159/000354212

Bowers, A. R., Anastasio, R. J., Sheldon, S. S., O’Connor, M. G., Hollis, A. M., Howe, P. D., & Horowitz, T. S. (2013). Can we improve clinical prediction of at-risk older drivers? Accident; Analysis and Prevention, 59, 537–47. http://doi.org/10.1016/j.aap.2013.06.037 Bozeat, S., Gregory, C. A., Ralph, M. A., & Hodges, J. R. (2000). Which neuropsychiatric and

behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer’s disease? Journal of Neurology, Neurosurgery, and Psychiatry, 69(2), 178–86.

Brayne, C., Dufouil, C., Ahmed, A., Dening, T. R., Chi, L. Y., McGee, M., & Huppert, F. A. (2000). Very old drivers: findings from a population cohort of people aged 84 and over. International Journal of Epidemiology, 29(4), 704–7.

Bridgeman, B., Blaesi, S., & Campusano, R. (2014). Optical Correction Reduces Simulator Sickness in a Driving Environment. Human Factors: The Journal of the Human Factors and Ergonomics Society, 56(8), 1472–1481. http://doi.org/10.1177/0018720814533992

Brodaty, H., Seeher, K., & Gibson, L. (2012). Dementia time to death: a systematic literature review on survival time and years of life lost in people with dementia. International Psychogeriatrics, 24(7), 1034–1045. http://doi.org/10.1017/S1041610211002924

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Cooper, P. J., Tallman, K., Tuokko, H., & Beattie, B. L. (1993). Vehicle crash involvement and cognitive deficit in older drivers. Journal of Safety Research, 24(1), 9–17. http://doi.org/10.1016/0022-4375(93)90047-Q

Cornutiu, G. (2015). The Epidemiological Scale of Alzheimer’s Disease. Journal of Clinical Medicine Research, 7(9), 657–66. http://doi.org/10.14740/jocmr2106w

Cox, D. J., Quillian, W. C., Thorndike, F. P., Kovatchev, B. P., & Hanna, G. (1998). Evaluating driving performance of outpatients with Alzheimer disease. The Journal of the American Board of Family Practice, 11(4), 264–71.

Crizzle, A. M., Classen, S., & Uc, E. Y. (2012). Parkinson disease and driving: An evidence-based review. Neurology, 79(20), 2067–2074.

http://doi.org/10.1212/WNL.0b013e3182749e95

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Davis, J. D., Papandonatos, G. D., Miller, L. A., Hewitt, S. D., Festa, E. K., Heindel, W. C., & Ott, B. R. (2012). Road Test and Naturalistic Driving Performance in Healthy and Cognitively Impaired Older Adults: Does Environment Matter? Journal of the American Geriatrics Society, 60(11), 2056–62. http://doi.org/10.1111/j.1532-5415.2012.04206.x Davis, R. L., & Ohman, J. M. (2016). Driving in Early-Stage Alzheimer’s Disease: An

Integrative Review of the Literature. Research in Gerontological Nursing, 1–15. http://doi.org/10.3928/19404921-20160920-02

Dawson, J. D., Anderson, S. W., Uc, E. Y., Dastrup, E., & Rizzo, M. (2009). Predictors of driving safety in early Alzheimer disease. Neurology, 72(6), 521–7. http://doi.org/ 10.1212/01.wnl.0000341931.35870.49

De Simone, V., Kaplan, L., Patronas, N., Wassermann, E. M., & Grafman, J. (2007). Driving Abilities in Frontotemporal Dementia Patients. Dement Geriatr Cogn Disord, 23, 1–7. http://doi.org/10.1159/000096317

de Waard, D., Dijksterhuis, C., & Brookhuis, K. A. (2009). Merging into heavy motorway traffic by young and elderly drivers. Accident Analysis & Prevention, 41(3), 588–597. http://doi.org/10.1016/j.aap.2009.02.011

Devlin, A., McGillivray, J., Charlton, J., Lowndes, G., & Etienne, V. (2012). Investigating driving behaviour of older drivers with mild cognitive impairment using a portable driving simulator. Accident Analysis & Prevention, 49, 300–307.

http://doi.org/10.1016/j.aap.2012.02.022

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http://doi.org/10.1002/mds.25387

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http://doi.org/10.5014/ajot.2013.005116

Cohen, J. (1988). Statistical power analysis for the behavioral sciences. (2nd ed.). Hillsdale, NJ: Erlbaum.

Cooper, P. J., Tallman, K., Tuokko, H., & Beattie, B. L. (1993). Vehicle crash involvement and cognitive deficit in older drivers. Journal of Safety Research, 24(1), 9–17. http://doi.org/10.1016/0022-4375(93)90047-Q

Cornutiu, G. (2015). The Epidemiological Scale of Alzheimer’s Disease. Journal of Clinical Medicine Research, 7(9), 657–66. http://doi.org/10.14740/jocmr2106w

Cox, D. J., Quillian, W. C., Thorndike, F. P., Kovatchev, B. P., & Hanna, G. (1998). Evaluating driving performance of outpatients with Alzheimer disease. The Journal of the American Board of Family Practice, 11(4), 264–71.

Crizzle, A. M., Classen, S., & Uc, E. Y. (2012). Parkinson disease and driving: An evidence-based review. Neurology, 79(20), 2067–2074.

http://doi.org/10.1212/WNL.0b013e3182749e95

Croston, J., Meuser, T. M., Berg-Weger, M., Grant, E. A., & Carr, D. B. (2009). Driving Retirement in Older Adults With Dementia. Topics in Geriatric Rehabilitation, 25(2), 154–162. http://doi.org/10.1097/TGR.0b013e3181a103fd

Davis, J. D., Papandonatos, G. D., Miller, L. A., Hewitt, S. D., Festa, E. K., Heindel, W. C., & Ott, B. R. (2012). Road Test and Naturalistic Driving Performance in Healthy and Cognitively Impaired Older Adults: Does Environment Matter? Journal of the American Geriatrics Society, 60(11), 2056–62. http://doi.org/10.1111/j.1532-5415.2012.04206.x Davis, R. L., & Ohman, J. M. (2016). Driving in Early-Stage Alzheimer’s Disease: An

Integrative Review of the Literature. Research in Gerontological Nursing, 1–15. http://doi.org/10.3928/19404921-20160920-02

Dawson, J. D., Anderson, S. W., Uc, E. Y., Dastrup, E., & Rizzo, M. (2009). Predictors of driving safety in early Alzheimer disease. Neurology, 72(6), 521–7. http://doi.org/ 10.1212/01.wnl.0000341931.35870.49

De Simone, V., Kaplan, L., Patronas, N., Wassermann, E. M., & Grafman, J. (2007). Driving Abilities in Frontotemporal Dementia Patients. Dement Geriatr Cogn Disord, 23, 1–7. http://doi.org/10.1159/000096317

de Waard, D., Dijksterhuis, C., & Brookhuis, K. A. (2009). Merging into heavy motorway traffic by young and elderly drivers. Accident Analysis & Prevention, 41(3), 588–597. http://doi.org/10.1016/j.aap.2009.02.011

Devlin, A., McGillivray, J., Charlton, J., Lowndes, G., & Etienne, V. (2012). Investigating driving behaviour of older drivers with mild cognitive impairment using a portable driving simulator. Accident Analysis & Prevention, 49, 300–307.

http://doi.org/10.1016/j.aap.2012.02.022

Devos, H., Nieuwboer, A., Vandenberghe, W., Tant, M., De Weerdt, W., & Uc, E. Y. (2014). On-road driving impairments in Huntington disease. Neurology, 82(11), 956–962. http://doi.org/10.1212/WNL.0000000000000220

Devos, H., Vandenberghe, W., Nieuwboer, A., Tant, M., Baten, G., & De Weerdt, W. (2007). Predictors of fitness to drive in people with Parkinson disease. Neurology, 69(14), 1434– 1441. http://doi.org/10.1212/01.wnl.0000277640.58685.fc

Devos, H., Vandenberghe, W., Nieuwboer, A., Tant, M., De Weerdt, W., Dawson, J. D., & Uc, E. Y. (2013). Validation of a screening battery to predict driving fitness in people with Parkinson’s disease. Movement Disorders, 28(5), 671–674.

http://doi.org/10.1002/mds.25387

Dickerson, A. E. (2014). Screening and assessment tools for determining fitness to drive: a review of the literature for the pathways project. Occupational Therapy in Health Care, 28(2), 82–121. http://doi.org/10.3109/07380577.2014.904535

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Dickerson, A. E., & Bédard, M. (2014). Decision Tool for Clients with Medical Issues: A Framework for Identifying Driving Risk and Potential to Return to Driving. Occupational Therapy In Health Care, 28(2), 194–202.

http://doi.org/10.3109/07380577.2014.903357

Dickson, D. W. (1999). Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration. Journal of Neurology, 246 Suppl 2, II6-15.

Dobbs, A. R. (2013). Accuracy of the DriveABLE cognitive assessment to determine cognitive fitness to drive. Canadian Family Physician Medecin de Famille Canadien, 59(3), e156-61. Dobbs, A. R., Heller, R. B., & Schopflocher, D. (1998). A comparative approach to identify

unsafe older drivers. Accident Analysis & Prevention, 30(3), 363–370. http://doi.org/10.1016/S0001-4575(97)00110-3

Dobbs, B. M., Carr, D. B., & Morris, J. C. (2002). Evaluation and management of the driver with dementia. The Neurologist, 8(2), 61–70.

Dobbs, B. M., & Shergill, S. S. (2013). How effective is the Trail Making Test (Parts A and B) in identifying cognitively impaired drivers? Age and Ageing, 42(5), 577–81. http://doi.org/10.1093/ageing/aft073

Domeyer, J. E., Cassavaugh, N. D., & Backs, R. W. (2013). The use of adaptation to reduce simulator sickness in driving assessment and research. Accident; Analysis and Prevention, 53, 127–32. http://doi.org/10.1016/j.aap.2012.12.039

Doumen, M., & Davidse, R. (2012). Samenstelling van een neuropsychologische testbatterij voor onderzoek naar de rijgeschiktheid van ouderen met cognitieve functiestoornissen. Leidschendam, the Netherlands.

Drachman, D. A., & Swearer, J. M. (1993). Driving and Alzheimer’s disease: the risk of crashes. Neurology, 43(12), 2448–56.

Drane, D. L., Yuspeh, R. L., Huthwaite, J. S., & Klingler, L. K. (2002). Demographic characteristics and normative observations for derived-trail making test indices. Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 15(1), 39–43.

Dubinsky, R. M., Stein, A. C., & Lyons, K. (2000). Practice parameter: Risk of driving and Alzheimer’s disease (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 54(12), 2205–2211. http://doi.org/10.1212/WNL.54.12.2205

Duchek, J. M., Carr, D. B., Hunt, L., Roe, C. M., Xiong, C., Shah, K., & Morris, J. C. (2003). Longitudinal Driving Performance in Early-Stage Dementia of the Alzheimer Type. Journal of the American Geriatrics Society, 51(10), 1342–1347.

http://doi.org/10.1046/j.1532-5415.2003.51481.x

Eby, D. W., Silverstein, N. M., Molnar, L. J., LeBlanc, D., & Adler, G. (2012). Driving behaviors in early stage dementia: A study using in-vehicle technology. Accident Analysis & Prevention, 49, 330–337. http://doi.org/10.1016/j.aap.2011.11.021

Edwards, C., Creaser, J., Caird, J., Lamsdale, A., & Chisholm, S. (2003). Older and younger driver performance at complex intersections: Implications for using perception-response time and driving simulation. In Proceedings of the Second International Driving Symposium on Human Factors in Driver Assessment, Training and Vehicle Design. Park City, Utah.

Elkin-Frankston, S., Lebowitz, B., Kapust, L., Hollis, A., & O’Connor, M. (2007). The use of the Color Trails Test in the assessment of driver competence: Preliminary report of a culture-fair instrument. Archives of Clinical Neuropsychology, 22(5), 631–635. http://doi.org/10.1016/J.ACN.2007.04.004

Emerson, J. L., Johnson, A. M., Dawson, J. D., Uc, E. Y., Anderson, S. W., & Rizzo, M. (2012). Predictors of driving outcomes in advancing age. Psychology and Aging, 27(3), 550–559. http://doi.org/10.1037/a0026359

Ernst, J., Krapp, S., Schuster, T., Förstl, H., Kurz, A., & Diehl-Schmid, J. (2010). [Car driving ability of patients with frontotemporal lobar degeneration and Alzheimer’s disease]. / Fahrtauglichkeit bei Patienten mit frontotemporaler und Alzheimer-Demenz. Der Nervenarzt, 81(1), 79–85. http://doi.org/10.1007/s00115-009-2847-5

Etienne, V., Marin-Lamellet, C., & Laurent, B. (2013). Mental flexibility impairment in drivers with early Alzheimer’s disease: A simulator-based study. IATSS Research, 37(1), 16–20. http://doi.org/10.1016/j.iatssr.2013.06.005

Fischer, P., Gatterer, G., Marterer, A., Simanyi, M., & Danielczyk, W. (1990). Course characteristics in the differentiation of dementia of the Alzheimer type and multi-infarct dementia. Acta Psychiatrica Scandinavica, 81(6), 551–3.

Fitten, L. J., Perryman, K. M., Wilkinson, C. J., Little, R. J., Burns, M. M., Pachana, N., … Ganzell, S. (1995). Alzheimer and vascular dementias and driving. A prospective road and laboratory study. JAMA, 273(17), 1360–5.

Foley, D. J., Heimovitz, H. K., Guralnik, J. M., & Brock, D. B. (2002). Driving life expectancy of persons aged 70 years and older in the United States. American Journal of Public Health, 92(8), 1284–9.

Foley, D. J., Masaki, K. H., Ross, G. W., & White, L. R. (2000). Driving cessation in older men with incident dementia. Journal of the American Geriatrics Society, 48(8), 928–30.

Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189–98.

Fox, G. K., Bowden, S. C., Bashford, G. M., & Smith, D. S. (1997). Alzheimer’s disease and driving: prediction and assessment of driving performance. Journal of the American Geriatrics Society, 45(8), 949–53.

Freeman, E. E., Muñoz, B., Turano, K. A., & West, S. K. (2005). Measures of visual function and time to driving cessation in older adults. Optometry and Vision Science : Official Publication of the American Academy of Optometry, 82(8), 765–73.

Freund, B. (2006). Office-Based Evaluation of the Older Driver. Journal of the American Geriatrics Society, 54(12), 1943–1944. http://doi.org/10.1111/j.1532-5415.2006.00966.x Freund, B., & Colgrove, L. A. A. (2008). Error specific restrictions for older drivers:

Promoting continued independence and public safety. Accident Analysis & Prevention, 40(1), 97–103. http://doi.org/10.1016/j.aap.2007.04.010

Freund, B., Colgrove, L. A., Petrakos, D., & McLeod, R. (2008). In my car the brake is on the right: Pedal errors among older drivers. Accident Analysis & Prevention, 40(1), 403–409. http://doi.org/10.1016/j.aap.2007.07.012

Freund, B., Gravenstein, S., Ferris, R., & Shaheen, E. (2002). Evaluating driving performance of cognitively impaired and healthy older adults: a pilot study comparing on-road testing and driving simulation. Journal of the American Geriatrics Society, 50(7), 1309–10. Friedland, R. P. (1997). Strategies for driving cessation in Alzheimer Disease. Alzheimer

Disease and Associated Disorders, 11 Suppl 1, 73–5.

Friedland, R. P., Koss, E., Kumar, A., Gaine, S., Metzler, D., Haxby, J. V., & Moore, A. (1988). Motor vehicle crashes in dementia of the alzheimer type. Annals of Neurology, 24(6), 782–786. http://doi.org/10.1002/ana.410240613

(8)

Dickerson, A. E., & Bédard, M. (2014). Decision Tool for Clients with Medical Issues: A Framework for Identifying Driving Risk and Potential to Return to Driving. Occupational Therapy In Health Care, 28(2), 194–202.

http://doi.org/10.3109/07380577.2014.903357

Dickson, D. W. (1999). Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration. Journal of Neurology, 246 Suppl 2, II6-15.

Dobbs, A. R. (2013). Accuracy of the DriveABLE cognitive assessment to determine cognitive fitness to drive. Canadian Family Physician Medecin de Famille Canadien, 59(3), e156-61. Dobbs, A. R., Heller, R. B., & Schopflocher, D. (1998). A comparative approach to identify

unsafe older drivers. Accident Analysis & Prevention, 30(3), 363–370. http://doi.org/10.1016/S0001-4575(97)00110-3

Dobbs, B. M., Carr, D. B., & Morris, J. C. (2002). Evaluation and management of the driver with dementia. The Neurologist, 8(2), 61–70.

Dobbs, B. M., & Shergill, S. S. (2013). How effective is the Trail Making Test (Parts A and B) in identifying cognitively impaired drivers? Age and Ageing, 42(5), 577–81. http://doi.org/10.1093/ageing/aft073

Domeyer, J. E., Cassavaugh, N. D., & Backs, R. W. (2013). The use of adaptation to reduce simulator sickness in driving assessment and research. Accident; Analysis and Prevention, 53, 127–32. http://doi.org/10.1016/j.aap.2012.12.039

Doumen, M., & Davidse, R. (2012). Samenstelling van een neuropsychologische testbatterij voor onderzoek naar de rijgeschiktheid van ouderen met cognitieve functiestoornissen. Leidschendam, the Netherlands.

Drachman, D. A., & Swearer, J. M. (1993). Driving and Alzheimer’s disease: the risk of crashes. Neurology, 43(12), 2448–56.

Drane, D. L., Yuspeh, R. L., Huthwaite, J. S., & Klingler, L. K. (2002). Demographic characteristics and normative observations for derived-trail making test indices. Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 15(1), 39–43.

Dubinsky, R. M., Stein, A. C., & Lyons, K. (2000). Practice parameter: Risk of driving and Alzheimer’s disease (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 54(12), 2205–2211. http://doi.org/10.1212/WNL.54.12.2205

Duchek, J. M., Carr, D. B., Hunt, L., Roe, C. M., Xiong, C., Shah, K., & Morris, J. C. (2003). Longitudinal Driving Performance in Early-Stage Dementia of the Alzheimer Type. Journal of the American Geriatrics Society, 51(10), 1342–1347.

http://doi.org/10.1046/j.1532-5415.2003.51481.x

Eby, D. W., Silverstein, N. M., Molnar, L. J., LeBlanc, D., & Adler, G. (2012). Driving behaviors in early stage dementia: A study using in-vehicle technology. Accident Analysis & Prevention, 49, 330–337. http://doi.org/10.1016/j.aap.2011.11.021

Edwards, C., Creaser, J., Caird, J., Lamsdale, A., & Chisholm, S. (2003). Older and younger driver performance at complex intersections: Implications for using perception-response time and driving simulation. In Proceedings of the Second International Driving Symposium on Human Factors in Driver Assessment, Training and Vehicle Design. Park City, Utah.

Elkin-Frankston, S., Lebowitz, B., Kapust, L., Hollis, A., & O’Connor, M. (2007). The use of the Color Trails Test in the assessment of driver competence: Preliminary report of a culture-fair instrument. Archives of Clinical Neuropsychology, 22(5), 631–635. http://doi.org/10.1016/J.ACN.2007.04.004

Emerson, J. L., Johnson, A. M., Dawson, J. D., Uc, E. Y., Anderson, S. W., & Rizzo, M. (2012). Predictors of driving outcomes in advancing age. Psychology and Aging, 27(3), 550–559. http://doi.org/10.1037/a0026359

Ernst, J., Krapp, S., Schuster, T., Förstl, H., Kurz, A., & Diehl-Schmid, J. (2010). [Car driving ability of patients with frontotemporal lobar degeneration and Alzheimer’s disease]. / Fahrtauglichkeit bei Patienten mit frontotemporaler und Alzheimer-Demenz. Der Nervenarzt, 81(1), 79–85. http://doi.org/10.1007/s00115-009-2847-5

Etienne, V., Marin-Lamellet, C., & Laurent, B. (2013). Mental flexibility impairment in drivers with early Alzheimer’s disease: A simulator-based study. IATSS Research, 37(1), 16–20. http://doi.org/10.1016/j.iatssr.2013.06.005

Fischer, P., Gatterer, G., Marterer, A., Simanyi, M., & Danielczyk, W. (1990). Course characteristics in the differentiation of dementia of the Alzheimer type and multi-infarct dementia. Acta Psychiatrica Scandinavica, 81(6), 551–3.

Fitten, L. J., Perryman, K. M., Wilkinson, C. J., Little, R. J., Burns, M. M., Pachana, N., … Ganzell, S. (1995). Alzheimer and vascular dementias and driving. A prospective road and laboratory study. JAMA, 273(17), 1360–5.

Foley, D. J., Heimovitz, H. K., Guralnik, J. M., & Brock, D. B. (2002). Driving life expectancy of persons aged 70 years and older in the United States. American Journal of Public Health, 92(8), 1284–9.

Foley, D. J., Masaki, K. H., Ross, G. W., & White, L. R. (2000). Driving cessation in older men with incident dementia. Journal of the American Geriatrics Society, 48(8), 928–30.

Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189–98.

Fox, G. K., Bowden, S. C., Bashford, G. M., & Smith, D. S. (1997). Alzheimer’s disease and driving: prediction and assessment of driving performance. Journal of the American Geriatrics Society, 45(8), 949–53.

Freeman, E. E., Muñoz, B., Turano, K. A., & West, S. K. (2005). Measures of visual function and time to driving cessation in older adults. Optometry and Vision Science : Official Publication of the American Academy of Optometry, 82(8), 765–73.

Freund, B. (2006). Office-Based Evaluation of the Older Driver. Journal of the American Geriatrics Society, 54(12), 1943–1944. http://doi.org/10.1111/j.1532-5415.2006.00966.x Freund, B., & Colgrove, L. A. A. (2008). Error specific restrictions for older drivers:

Promoting continued independence and public safety. Accident Analysis & Prevention, 40(1), 97–103. http://doi.org/10.1016/j.aap.2007.04.010

Freund, B., Colgrove, L. A., Petrakos, D., & McLeod, R. (2008). In my car the brake is on the right: Pedal errors among older drivers. Accident Analysis & Prevention, 40(1), 403–409. http://doi.org/10.1016/j.aap.2007.07.012

Freund, B., Gravenstein, S., Ferris, R., & Shaheen, E. (2002). Evaluating driving performance of cognitively impaired and healthy older adults: a pilot study comparing on-road testing and driving simulation. Journal of the American Geriatrics Society, 50(7), 1309–10. Friedland, R. P. (1997). Strategies for driving cessation in Alzheimer Disease. Alzheimer

Disease and Associated Disorders, 11 Suppl 1, 73–5.

Friedland, R. P., Koss, E., Kumar, A., Gaine, S., Metzler, D., Haxby, J. V., & Moore, A. (1988). Motor vehicle crashes in dementia of the alzheimer type. Annals of Neurology, 24(6), 782–786. http://doi.org/10.1002/ana.410240613

(9)

Frittelli, C., Borghetti, D., Iudice, G., Bonanni, E., Maestri, M., Tognoni, G., … Iudice, A. (2009). Effects of Alzheimer’s disease and mild cognitive impairment on driving ability: a controlled clinical study by simulated driving test. International Journal of Geriatric Psychiatry, 24(3), 232–238. http://doi.org/10.1002/gps.2095

Frucht, S., Rogers, J. D., Greene, P. E., Gordon, M. F., & Fahn, S. (1999). Falling asleep at the wheel: motor vehicle mishaps in persons taking pramipexole and ropinirole. Neurology, 52(9), 1908–10.

Fuermaier, A. B. M., Piersma, D., de Waard, D., Davidse, R. J., de Groot, J., Doumen, M. J. A., … Tucha, O. (2017). Assessing fitness to drive - A validation study on patients with Mild Cognitive Impairment. Traffic Injury Prevention, 18(2), 145–149. http://doi.org/10.1080/15389588.2016.1232809

Fujito, R., Kamimura, N., Ikeda, M., Koyama, A., Shimodera, S., Morinobu, S., & Inoue, S. (2016). Comparing the driving behaviours of individuals with frontotemporal lobar degeneration and those with Alzheimer’s disease. Psychogeriatrics, 16(1), 27–33. http://doi.org/10.1111/psyg.12115

Gergerich, E. M. (2016). Reporting Policy Regarding Drivers with Dementia. The Gerontologist, 56(2), 345–356. http://doi.org/10.1093/geront/gnv143

Gifford, R. (2013). Flawed conclusion. Canadian Family Physician, 59(7), 726–727.

Gill, D. P., Hubbard, R. A., Koepsell, T. D., Borrie, M. J., Petrella, R. J., Knopman, D. S., & Kukull, W. A. (2013). Differences in rate of functional decline across three dementia types. Alzheimer’s & Dementia : The Journal of the Alzheimer’s Association, 9(5 Suppl), S63-71. http://doi.org/10.1016/j.jalz.2012.10.010

Gilley, D. W., Wilson, R. S., Bennett, D. A., Stebbins, G. T., Bernard, B. A., Whalen, M. E., & Fox, J. H. (1991). Cessation of driving and unsafe motor vehicle operation by dementia patients. Archives of Internal Medicine, 151(5), 941–6.

Goodman, R. A., Lochner, K. A., Thambisetty, M., Wingo, T. S., Posner, S. F., & Ling, S. M. (2016). Prevalence of dementia subtypes in United States Medicare fee-for-service beneficiaries, 2011-2013. Alzheimer’s & Dementia : The Journal of the Alzheimer’s Association, 13(1), 28–37. http://doi.org/10.1016/j.jalz.2016.04.002

Gorno-Tempini, M. L., Brambati, S. M., Ginex, V., Ogar, J., Dronkers, N. F., Marcone, A., … Miller, B. L. (2008). The logopenic/phonological variant of primary progressive aphasia. Neurology, 71(16), 1227–1234. http://doi.org/10.1212/01.wnl.0000320506.79811.da Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. F., …

Grossman, M. (2011). Classification of primary progressive aphasia and its variants. Neurology, 76(11), 1006–14. http://doi.org/10.1212/WNL.0b013e31821103e6

Graham, N. L., Bak, T. H., & Hodges, J. R. (2003). Corticobasal degeneration as a cognitive disorder. Movement Disorders, 18(11), 1224–1232. http://doi.org/10.1002/mds.10536 Hakamies-Blomqvist, L., Johansson, K., & Lundberg, C. (1996). Medical Screening of Older

Drivers as a Traffic Safety Measure-A Comparative Finnish-Swedish Evaluation Study. Journal of the American Geriatrics Society, 44(6), 650–653.

http://doi.org/10.1111/j.1532-5415.1996.tb01826.x

Hanyu, H., Sato, T., Hirao, K., Kanetaka, H., Sakurai, H., & Iwamoto, T. (2009). Differences in clinical course between dementia with Lewy bodies and Alzheimer’s disease. European Journal of Neurology, 16(2), 212–217. http://doi.org/10.1111/j.1468-1331.2008.02388.x Hebert, L. E., Scherr, P. A., Bienias, J. L., Bennett, D. A., & Evans, D. A. (2003). Alzheimer

Disease in the US Population. Archives of Neurology, 60(8), 1119–22. http://doi.org/10.1001/archneur.60.8.1119

Herrmann, N., Rapoport, M. J., Sambrook, R., Hébert, R., McCracken, P., Robillard, A., & Canadian Outcomes Study in Dementia (COSID) Investigators. (2006). Predictors of driving cessation in mild-to-moderate dementia. Canadian Medical Association Journal, 175(6), 591–595. http://doi.org/10.1503/cmaj.051707

Hill, L. L., Rybar, J., & Styer, T. (2013). Evaluation of curriculum to improve health professionals’ ability to manage age-related driving impairments. Accident Analysis & Prevention, 61, 222–232. http://doi.org/10.1016/j.aap.2012.09.026

Hines, A., & Bundy, A. C. (2014). Predicting driving ability using DriveSafe and DriveAware in people with cognitive impairments: A replication study. Australian Occupational Therapy Journal, 61(4), 224–229. http://doi.org/10.1111/1440-1630.12112

Hoggarth, P. A., Innes, C. R. H., Dalrymple-Alford, J. C., & Jones, R. D. (2013). Predicting On-Road Assessment Pass and Fail Outcomes in Older Drivers with Cognitive Impairment Using a Battery of Computerized Sensory-Motor and Cognitive Tests. Journal of the American Geriatrics Society, 61(12), 2192–2198. http://doi.org/10.1111/jgs.12540

Hollis, A. M., Lee, A. K. W., Kapust, L. R., Phillips, L. K., Wolkin, J., & O’Connor, M. G. (2013). The Driving Competence of 90-Year-Old Drivers: From a Hospital-Based Driving Clinic. Traffic Injury Prevention, 14(8), 782–790.

http://doi.org/10.1080/15389588.2013.777957

Hoops, S., Nazem, S., Siderowf, A. D., Duda, J. E., Xie, S. X., Stern, M. B., & Weintraub, D. (2009). Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease. Neurology, 73(21), 1738–1745.

http://doi.org/10.1212/WNL.0b013e3181c34b47

Hope, T., Keene, J., Fairburn, C. G., Jacoby, R., & McShane, R. (1999). Natural history of behavioural changes and psychiatric symptoms in Alzheimer’s disease. A longitudinal study. The British Journal of Psychiatry : The Journal of Mental Science, 174, 39–44.

Horswill, M., Anstey, K., Hatherly, C., & Wood, J. (2010). The crash involvement of older drivers is associated with their hazard perception latencies. Journal of the International Neuropsychological Society, 16(5), 939–944. http://doi.org/10.1017/S135561771000055X Huisingh, C., McGwin, G., & Owsley, C. (2016). Association of visual sensory function and

higher-order visual processing skills with incident driving cessation. Clinical and Experimental Optometry, 99(5), 441–448. http://doi.org/10.1111/cxo.12404

Hunt, L. A., Murphy, C. F., Carr, D., Duchek, J. M., Buckles, V., & Morris, J. C. (1997). Reliability of the Washington University Road Test. A performance-based assessment for drivers with dementia of the Alzheimer type. Archives of Neurology, 54(6), 707–12. Hunt, L., Morris, J. C., Edwards, D., & Wilson, B. S. (1993). Driving performance in persons

with mild senile dementia of the Alzheimer type. Journal of the American Geriatrics Society, 41(7), 747–52.

ICADTS. (2007). [updated 2007 July; cited 2015 June 22]. Available from: http://www.icadts.nl/medicinal.html. Ann Arbor, USA: The International Council on Alcohol, Drugs and Traffic Safety.

Ikejima, C., Yasuno, F., Mizukami, K., Sasaki, M., Tanimukai, S., & Asada, T. (2009). Prevalence and Causes of Early-Onset Dementia in Japan: A Population-Based Study. Stroke, 40(8), 2709–2714. http://doi.org/10.1161/STROKEAHA.108.542308

Innes, C. R. H., Lee, D., Chen, C., Ponder-Sutton, A. M., Melzer, T. R., & Jones, R. D. (2011). Do complex models increase prediction of complex behaviours? Predicting driving ability in people with brain disorders. The Quarterly Journal of Experimental Psychology, 64(9), 1714–1725. http://doi.org/10.1080/17470218.2011.555821

(10)

Frittelli, C., Borghetti, D., Iudice, G., Bonanni, E., Maestri, M., Tognoni, G., … Iudice, A. (2009). Effects of Alzheimer’s disease and mild cognitive impairment on driving ability: a controlled clinical study by simulated driving test. International Journal of Geriatric Psychiatry, 24(3), 232–238. http://doi.org/10.1002/gps.2095

Frucht, S., Rogers, J. D., Greene, P. E., Gordon, M. F., & Fahn, S. (1999). Falling asleep at the wheel: motor vehicle mishaps in persons taking pramipexole and ropinirole. Neurology, 52(9), 1908–10.

Fuermaier, A. B. M., Piersma, D., de Waard, D., Davidse, R. J., de Groot, J., Doumen, M. J. A., … Tucha, O. (2017). Assessing fitness to drive - A validation study on patients with Mild Cognitive Impairment. Traffic Injury Prevention, 18(2), 145–149. http://doi.org/10.1080/15389588.2016.1232809

Fujito, R., Kamimura, N., Ikeda, M., Koyama, A., Shimodera, S., Morinobu, S., & Inoue, S. (2016). Comparing the driving behaviours of individuals with frontotemporal lobar degeneration and those with Alzheimer’s disease. Psychogeriatrics, 16(1), 27–33. http://doi.org/10.1111/psyg.12115

Gergerich, E. M. (2016). Reporting Policy Regarding Drivers with Dementia. The Gerontologist, 56(2), 345–356. http://doi.org/10.1093/geront/gnv143

Gifford, R. (2013). Flawed conclusion. Canadian Family Physician, 59(7), 726–727.

Gill, D. P., Hubbard, R. A., Koepsell, T. D., Borrie, M. J., Petrella, R. J., Knopman, D. S., & Kukull, W. A. (2013). Differences in rate of functional decline across three dementia types. Alzheimer’s & Dementia : The Journal of the Alzheimer’s Association, 9(5 Suppl), S63-71. http://doi.org/10.1016/j.jalz.2012.10.010

Gilley, D. W., Wilson, R. S., Bennett, D. A., Stebbins, G. T., Bernard, B. A., Whalen, M. E., & Fox, J. H. (1991). Cessation of driving and unsafe motor vehicle operation by dementia patients. Archives of Internal Medicine, 151(5), 941–6.

Goodman, R. A., Lochner, K. A., Thambisetty, M., Wingo, T. S., Posner, S. F., & Ling, S. M. (2016). Prevalence of dementia subtypes in United States Medicare fee-for-service beneficiaries, 2011-2013. Alzheimer’s & Dementia : The Journal of the Alzheimer’s Association, 13(1), 28–37. http://doi.org/10.1016/j.jalz.2016.04.002

Gorno-Tempini, M. L., Brambati, S. M., Ginex, V., Ogar, J., Dronkers, N. F., Marcone, A., … Miller, B. L. (2008). The logopenic/phonological variant of primary progressive aphasia. Neurology, 71(16), 1227–1234. http://doi.org/10.1212/01.wnl.0000320506.79811.da Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. F., …

Grossman, M. (2011). Classification of primary progressive aphasia and its variants. Neurology, 76(11), 1006–14. http://doi.org/10.1212/WNL.0b013e31821103e6

Graham, N. L., Bak, T. H., & Hodges, J. R. (2003). Corticobasal degeneration as a cognitive disorder. Movement Disorders, 18(11), 1224–1232. http://doi.org/10.1002/mds.10536 Hakamies-Blomqvist, L., Johansson, K., & Lundberg, C. (1996). Medical Screening of Older

Drivers as a Traffic Safety Measure-A Comparative Finnish-Swedish Evaluation Study. Journal of the American Geriatrics Society, 44(6), 650–653.

http://doi.org/10.1111/j.1532-5415.1996.tb01826.x

Hanyu, H., Sato, T., Hirao, K., Kanetaka, H., Sakurai, H., & Iwamoto, T. (2009). Differences in clinical course between dementia with Lewy bodies and Alzheimer’s disease. European Journal of Neurology, 16(2), 212–217. http://doi.org/10.1111/j.1468-1331.2008.02388.x Hebert, L. E., Scherr, P. A., Bienias, J. L., Bennett, D. A., & Evans, D. A. (2003). Alzheimer

Disease in the US Population. Archives of Neurology, 60(8), 1119–22. http://doi.org/10.1001/archneur.60.8.1119

Herrmann, N., Rapoport, M. J., Sambrook, R., Hébert, R., McCracken, P., Robillard, A., & Canadian Outcomes Study in Dementia (COSID) Investigators. (2006). Predictors of driving cessation in mild-to-moderate dementia. Canadian Medical Association Journal, 175(6), 591–595. http://doi.org/10.1503/cmaj.051707

Hill, L. L., Rybar, J., & Styer, T. (2013). Evaluation of curriculum to improve health professionals’ ability to manage age-related driving impairments. Accident Analysis & Prevention, 61, 222–232. http://doi.org/10.1016/j.aap.2012.09.026

Hines, A., & Bundy, A. C. (2014). Predicting driving ability using DriveSafe and DriveAware in people with cognitive impairments: A replication study. Australian Occupational Therapy Journal, 61(4), 224–229. http://doi.org/10.1111/1440-1630.12112

Hoggarth, P. A., Innes, C. R. H., Dalrymple-Alford, J. C., & Jones, R. D. (2013). Predicting On-Road Assessment Pass and Fail Outcomes in Older Drivers with Cognitive Impairment Using a Battery of Computerized Sensory-Motor and Cognitive Tests. Journal of the American Geriatrics Society, 61(12), 2192–2198. http://doi.org/10.1111/jgs.12540

Hollis, A. M., Lee, A. K. W., Kapust, L. R., Phillips, L. K., Wolkin, J., & O’Connor, M. G. (2013). The Driving Competence of 90-Year-Old Drivers: From a Hospital-Based Driving Clinic. Traffic Injury Prevention, 14(8), 782–790.

http://doi.org/10.1080/15389588.2013.777957

Hoops, S., Nazem, S., Siderowf, A. D., Duda, J. E., Xie, S. X., Stern, M. B., & Weintraub, D. (2009). Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease. Neurology, 73(21), 1738–1745.

http://doi.org/10.1212/WNL.0b013e3181c34b47

Hope, T., Keene, J., Fairburn, C. G., Jacoby, R., & McShane, R. (1999). Natural history of behavioural changes and psychiatric symptoms in Alzheimer’s disease. A longitudinal study. The British Journal of Psychiatry : The Journal of Mental Science, 174, 39–44.

Horswill, M., Anstey, K., Hatherly, C., & Wood, J. (2010). The crash involvement of older drivers is associated with their hazard perception latencies. Journal of the International Neuropsychological Society, 16(5), 939–944. http://doi.org/10.1017/S135561771000055X Huisingh, C., McGwin, G., & Owsley, C. (2016). Association of visual sensory function and

higher-order visual processing skills with incident driving cessation. Clinical and Experimental Optometry, 99(5), 441–448. http://doi.org/10.1111/cxo.12404

Hunt, L. A., Murphy, C. F., Carr, D., Duchek, J. M., Buckles, V., & Morris, J. C. (1997). Reliability of the Washington University Road Test. A performance-based assessment for drivers with dementia of the Alzheimer type. Archives of Neurology, 54(6), 707–12. Hunt, L., Morris, J. C., Edwards, D., & Wilson, B. S. (1993). Driving performance in persons

with mild senile dementia of the Alzheimer type. Journal of the American Geriatrics Society, 41(7), 747–52.

ICADTS. (2007). [updated 2007 July; cited 2015 June 22]. Available from: http://www.icadts.nl/medicinal.html. Ann Arbor, USA: The International Council on Alcohol, Drugs and Traffic Safety.

Ikejima, C., Yasuno, F., Mizukami, K., Sasaki, M., Tanimukai, S., & Asada, T. (2009). Prevalence and Causes of Early-Onset Dementia in Japan: A Population-Based Study. Stroke, 40(8), 2709–2714. http://doi.org/10.1161/STROKEAHA.108.542308

Innes, C. R. H., Lee, D., Chen, C., Ponder-Sutton, A. M., Melzer, T. R., & Jones, R. D. (2011). Do complex models increase prediction of complex behaviours? Predicting driving ability in people with brain disorders. The Quarterly Journal of Experimental Psychology, 64(9), 1714–1725. http://doi.org/10.1080/17470218.2011.555821

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