University of Groningen
The two sides of the coin of psychosocial stress
Kopschina Feltes, Paula
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Publication date:
2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Kopschina Feltes, P. (2018). The two sides of the coin of psychosocial stress: Evaluation by positron
emission tomography. University of Groningen.
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PROPOSITIONS
Belonging to the PhD thesis
“The two sides of the coin of psychosocial stress: evaluation by positron
emission tomography”
by
Paula Kopschina Feltes
1. “Psychosocial and physical stressors capable of inducing glial activation may have a causal role in the onset of depression, in particular in the subgroup of treatment-resistant patients.” [Chapter 1]
2. “In particular depressed patients with elevated levels of inflammatory markers may benefit from personalized treatment algorithms and more assertive adjuvant strategies with non-steroidal anti-inflammatory drugs.” [Chapter 2]
3. For personalized treatment in depression, characterization of abnormal processes in the brain with non-invasive imaging tools like PET is highly recommended. [This thesis]
4. “Exposure to psychosocial stress early in life is a risk factor for a more pronounced depressive behaviour in the event of a secondary exposure later in life.” [This thesis]
5. “11C-PBR28 standardized uptake values (SUV) are strongly correlated with the volume of
distribution (VT), indicating that the SUV can be used to quantify 11C-PBR28 uptake in
preclinical studies, simplifying the imaging procedure, enabling longitudinal studies and reducing the number of experimental animals needed.” [Chapter 4; Chapter 5]
6. “The RSD model provokes appetitive aggression, with repetitive winning of aggressive confrontations being a source of pleasure for the resident rats”. [Chapter 6]
7. “Venturing into the field of depression is akin to an adventure into the unknown, since its aetiology and mechanisms have not yet been fully elucidated.” [Robert Dantzer]. However, through well-designed preclinical studies and clinical trials, we can create the pieces to solve this puzzle.
8. “If pursuing a PhD degree can be compared to running a marathon” [PhD students’ common knowledge] “… following a double PhD programme is comparable to competing in the Ironman triathlon.” [Personal experience]
9. “Have no fear of perfection – you’ll never reach it.” [Salvador Dalí]. Also in science perfection cannot be reached, as there will always be new questions, even when you have finished your manuscripts or thesis: that is the fun of obtaining a PhD! [Personal experience] 10. “Writing a manuscript is like an iterative image reconstruction – it takes multiple steps to get the best results.” [E-mail communication during a manuscript revision]
11. In a challenging environment where funding is often scarce, contributions to science can still be made through networking.” [Personal experience from the PhD period spent in Brazil]
