de Graaf, Gimon
DOI:
10.33612/diss.100467716
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Publication date: 2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
de Graaf, G. (2019). Eyes on the prize: early economic evaluation to guide translational research: examples from the development of biomarkers for type 2 diabetes. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.100467716
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Eyes on the prize:
early economic evaluation to guide
translational research
Examples from the development of biomarkers for type 2
diabetes
of the Center for Translational Molecular Medicine (CTMM); project PREDICCt, and supported by the Dutch Heart Foundation, Dutch Diabetes Research Foundation, and Dutch Kidney Foundation.
Copyright © 2019 Gimon de Graaf
All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any way or by any means without the prior permission of the author, or when applicable, of the publishers of the scientific papers.
Cover design by Seroj de Graaf | Seroj.nl
Layout and design by David de Groot | Persoonlijkproefschrift.nl Printed by Ridderprint BV | Ridderprint.nl
Eyes on the prize:
early economic evaluation to guide
translational research
Examples from the development of biomarkers for type 2
diabetes
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 13 november 2019 om 16.15 uur
door
Gimon de Graaf geboren op 15 november 1984
Prof. dr. H.W. Frijlink Prof. dr. K.G.M. Moons Prof. dr. J.L. Severens
CONTENTS
CHAPTER 1 7
General introduction
CHAPTER 2 23
Using multi-criteria decision analysis to support research priority setting in biomedical translational research projects
CHAPTER 3 47
The early economic evaluation of novel biomarkers to accelerate their translation into clinical applications
CHAPTER 4 69
A method for the early health technology assessment of novel biomarker measurement in primary prevention programs
CHAPTER 5 97
Design of stepwise screening for prediabetes and type 2 diabetes based on costs and cases detected
CHAPTER 6 121
The impact of short lead time for diabetes on the cost-effectiveness of treating patients Identified in prediabetes screening
CHAPTER 7 141 General discussion CHAPTER 8 167 Summary 168 Nederlandse samenvatting 172 Dankwoord 176 Other SHARE dissertations 184 About the author 188
