Image-guided surgery using invisible near-infrared fluorescent light : from pre-clinical studies to clinical validation
Hutteman, M.
Citation
Hutteman, M. (2011, September 1). Image-guided surgery using invisible near-infrared fluorescent light : from pre-clinical studies to clinical validation. Retrieved from https://hdl.handle.net/1887/17805
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/17805
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Image-Guided Surgery using Invisible Near-Infrared
Fluorescent Light
From pre-clinical studies to clinical validation
Merlijn Hutteman
Cover design: Matthijs Braamhaar
© M. Hutteman, 2011 ISBN 978-94-6169-112-5
The research described in this thesis was financially supported by the Center for Translational Molecular Medicine (CTMM, DeCoDe and MUSIS projects), the Dutch Cancer Society, Foundation “De Drie Lichten” and the Leiden University Fund (LUF).
Image-Guided Surgery using Invisible Near-Infrared Fluorescent Light
From pre-clinical studies to clinical validation
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op woensdag 1 september 2011
klokke 16.15 uur
door
Merlijn Hutteman
geboren te Rotterdam in 1983
Promotiecommissie
Promotores: Prof. dr. C.J.H. van de Velde
Prof. dr. J.V. Frangioni (Harvard University) Co-promotores: Dr. A.L. Vahrmeijer
Dr. P.J.K. Kuppen Overige leden: Prof. dr. B.P.F. Lelieveldt
Prof. dr. C.W.G.M. Löwik Prof. dr. J.H.C. Reiber Dr. V.T.H.B.M. Smit Prof. dr. H.J. Tanke
To my family
CoNteNtS
Chapter 1 General introduction and thesis outline 9
Part I Pre-clinical validation of near-infrared fluorescence image-
guided surgery 17
Chapter 2 Intraoperative near-infrared fluorescence imaging of colorectal metastases targeting integrin αvβ3 expression in a syngeneic rat model
19
Chapter 3 Image-guided tumor resection using real-time near-infrared fluorescence in a syngeneic rat model of primary breast cancer 31 Chapter 4 Near-infrared fluorescence imaging of liver metastases in rats
using indocyanine green 51
Part II Clinical translation 63
Chapter 5 Clinical translation of ex vivo sentinel lymph node mapping for colorectal cancer using invisible near-infrared fluorescence light 65 Chapter 6 Towards optimization of imaging system and lymphatic tracer for
near-infrared fluorescent sentinel lymph node mapping in breast cancer
81
Chapter 7 Randomized, double-blind comparison of indocyanine green with or without albumin premixing for near-infrared fluorescence imaging of sentinel lymph nodes in breast cancer patients
97
Chapter 8 Optimization of near-infrared fluorescent sentinel lymph node
mapping in cervical cancer patients 109
Chapter 9 Optimization of near-infrared fluorescent sentinel lymph node
mapping for vulvar cancer 123
Chapter 10 The FLARE™ intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in perforator flap breast reconstruction
133
Chapter 11 Near-infrared fluorescence imaging in patients undergoing
pancreaticoduodenectomy 149
Chapter 12 Identification and image-guided resection of occult superficial liver metastases using indocyanine green and near-infrared fluorescence imaging
163
Chapter 13 Summary and future perspectives 177
Chapter 14 Nederlandse samenvatting 187
List of publications 193
Curriculum Vitae 195
Acknowledgements 197
