White matters : a longitudinal study on causes and consequences of
white matter hyperintensities in the elderly.
Heuvel, D.M.J. van den
Citation
Heuvel, D. M. J. van den. (2005, November 17). White matters : a longitudinal study on
causes and consequences of white matter hyperintensities in the elderly. Retrieved from
https://hdl.handle.net/1887/3729
Version:
Corrected Publisher’s Version
License:
Licence agreement concerning inclusion of doctoral thesis in the
Institutional Repository of the University of Leiden
Downloaded from:
https://hdl.handle.net/1887/3729
WHITE MATTERS
ISBN: 90-9019785-0
Designed by: W.G.M. van den Heuvel
Printed by: Febo druk BV, Enschede, the Netherlands
© 2005, D.M.J. van den Heuvel, except (parts of) the following chapters Chapter 3: Elsevier
Chapter 4: American Society of Neuroradiology Chapter 5,9: Lippincot, Williams & Wilkins Chapter 8: BMJ publishing group Ltd.
No part of this thesis may be reproduced in any form by print, photocopy, digital file, inter-net or any other means without written permission of the copyright owner.
The studies described in this thesis were performed at the department of Radiology and Gerontology and Geriatrics of the Leiden University Medical Center, Leiden, The Netherlands and were financially supported by an investigator initiated grant from Bristol Myers-Squibb, Princeton, USA. The sponsor had no role in the design, data collection, data analyses, data interpretation of the study or writing of the paper.
WHITE MATTERS
A longitudinal study on causes and consequences of white matter hyperintensities in the elderly
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit van Leiden, op gezag van de Rector Magnificus Dr. D.D. Breimer,
hoogleraar in de faculteit der Wiskunde en Natuurwetenschappen en die der Geneeskunde,
volgens besluit van het College voor Promoties te verdedigen op donderdag 17 november 2005
klokke 15.15 uur door
Dominique Marie Joseph van den Heuvel geboren te Boxmeer
Promotores:
Prof. Dr. M.A. van Buchem Prof. Dr. R.G.J. Westendorp Co-Promotor:
Dr. A.J.M. de Craen Referent:
Dr. L. Launer (National Institutes of Health, Bethesda, USA) Overige Leden:
Contents
1. General Introduction
Page 7 - 14
2. The PROspective Study of Pravastatin in the Elderly at Risk; rationale, study design and main findings
Page 15 - 24
3. Fully automatic segmentation of white matter hyperintensities in MR images of the elderly
Page 25 - 46
4. Measuring longitudinal white matter changes: comparison of a visual rating scale with a volumetric measurement
Page 47 - 60
5. Different progression rates for deep white matter hyperintensities in elderly men and women
Page 61 - 70
6. Decline of cerebral blood flow is linked with increase of periventricular but not deep white matter hyperintensities
Page 71 - 84
7. Impact of cardiovascular risk factors on the progression of periventricular and deep white matter hyperintensities
Page 85 - 98
8. Increase in periventricular white matter hyperintensities parallels decline in mental processing speed in a non-demented elderly population
Page 99 - 116
9. Effect of pravastatin on cerebral infarcts and white matter lesions
Page 117 - 126
10. General Discussion
Page 127 - 140
I. Appendix
Page 141 - 148
II. Nederlandse samenvatting
Page 149 - 154
III. Nawoord - List of publications - Curriculum Vitae
