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MR based electric properties imaging for hyperthermia treatment planning and
MR safety purposes
Balidemaj, E.
Publication date
2016
Document Version
Final published version
Link to publication
Citation for published version (APA):
Balidemaj, E. (2016). MR based electric properties imaging for hyperthermia treatment
planning and MR safety purposes.
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MR based electric properties imaging
for hyperthermia treatment planning
and MR safety purposes
Cover design: Albert Balidemaj Layout: Edmond Balidemaj ISBN: 978-94-028-0165-1
Printed by: Ipskamp printing, Enschede
Copyright of the published articles in this thesis has been transferred to the associated publishers.
The research presented in this thesis was carried out at the Department of Radiation Oncology, Academic Medical Center, University of Amsterdam.
Financial support for publication of this thesis was kindly provided by AMC Medical Research B.V. and Philips Medical Systems BV, Best, The Netherlands.
The research was financially supported by a generous grant from the Koningin Wilhelmina Fonds – Dutch Cancer Society (KWF-Kankerbestrijding):
KWF project UVA 2010-4660 Improved regional hyperthermia delivery using hyperthermia treatment planning based on MRI data to predict and suppress treatment limiting hot spots.
Project leaders: Dr. J. (Hans) Crezee, Dr. Aart J. Nederveen, Prof. Dr. Lukas J.A. Stalpers.
MR based electric properties imaging
for hyperthermia treatment planning
and MR safety purposes
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus
prof. dr. D.C. van den Boom
ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Aula der Universiteit
op woensdag 25 mei 2016, te 13:00 uur door
Edmond Balidemaj geboren te Gjilan, Kosovo
Promotiecommissie:
Promotores: Prof. Dr. C.R.N. Rasch Universiteit van Amsterdam Prof. Dr. L.J.A. Stalpers Universiteit van Amsterdam Copromotores: Dr. J. Crezee Universiteit van Amsterdam Dr. R. F. Remis Technische Universiteit Delft Overige leden: Prof. Dr. J. J. W. Lagendijk Universiteit Utrecht
Prof. Dr. G. G. Kenter Universiteit van Amsterdam Prof. Dr. J. Stoker Universiteit van Amsterdam Prof. Dr. G. C. van Rhoon Erasmus Universiteit Rotterdam Prof. Dr. G. J. Strijkers Universiteit van Amsterdam Dr. U. Katscher Philips Research Laboratories
Dr. A. Bel Universiteit van Amsterdam
Contents
1 Introduction ... 1
1.1 Introduction to Hyperthermia ...1
1.2 Biological rationale ...1
1.3 Hyperthermia in the clinic ...2
1.3.1 Local Hyperthermia ...2
1.3.2 Superficial Hyperthermia ...2
1.3.3 Loco-regional Hyperthermia ...2
1.3.4 Whole-body Hyperthermia...4
1.4 Hyperthermia Treatment Planning ...4
1.5 Outline of this thesis ...6
2 Electric properties imaging ... 9
2.1 Electric properties ...9
2.2 Magnetic Resonance Imaging ...9
2.3 Electric Properties Tomography ... 10
2.4 Contrast Source Inversion – Electric Properties Tomography (CSI-EPT)..12
3 Feasibility of Electric Property Tomography of Pelvic Tumors at 3T ... 17
3.1 Introduction ... 18 3.2 Methods ... 19 3.2.1 EPT reconstruction ... 20 3.2.2 Phantom ... 21 3.2.3 Simulation ... 22 3.2.4 MR measurements ... 22 3.2.5 Postprocessing ... 23 3.3 Results ... 23 3.3.1 Phase error ... 23
3.3.3 In vivo simulations and measurements... 26
3.4 Discussion ... 27
3.5 Conclusion ... 31
4 In vivo electric conductivity of cervical cancer patients based on 𝐁𝟏 + maps at 3T MRI ... 35
4.1. Introduction ... 36
4.2. Methods ... 37
4.2.1. MR measurements ... 37
4.2.2. EPT Reconstruction ... 38
4.2.3. Quantification of in vivo data ... 38
4.3. Results ... 39 4.3.1. Muscle ... 39 4.3.2. Bladder content/Urine ... 39 4.3.3. Cervical tumor ... 39 4.4. Discussion ... 42 4.4.1. Muscle ... 43 4.4.2. Bladder content/Urine ... 44 4.4.3. Cervical tumor ... 44 4.5. Conclusion ... 45
5 Hyperthermia Treatment Planning for cervical cancer patients based on electric conductivity tissue properties acquired in vivo with EPT at 3T MRI ... 51
5.1. Introduction ... 52
5.2. Methods & Meterials ... 54
5.2.1. Patient models ... 54
5.2.2. Temperature optimization ... 54
5.2.3. Impact of EPT based conductivity values ... 55
5.2.4. Impact of muscle permittivity variation ... 57
5.3. Results ... 58
5.3.1. Impact of EPT based conductivity values ... 58
5.3.2. Impact of muscle permittivity variation ... 59
5.3.3. Impact of EPT based patient model on optimized temperature distribution ... 60
5.4. Discussion ... 65
5.5. Conclusion ... 67
6 CSI-EPT: A Contrast Source Inversion Approach for Improved MRI-Based Electric Properties Tomography ... 73
6.1 Introduction ... 74
6.2 Basic equations ... 76
6.2.1 The Contrast Source Inversion Method ... 78
6.2.2 Multiple Antenna Settings and Multiplicative Regularization ... 79
6.3 Numerical Results ... 81
6.4 Discussion ... 83
7 B1 based SAR reconstruction using Contrast Source Inversion - Electric Properties Tomography (CSI-EPT) ... 93
7.1 Introduction ... 94
7.2 Methods ... 95
7.2.1 The CSI-EPT Method ... 95
7.2.2 3D and 2D electromagnetic modeling ... 97
7.3 Results ... 98
7.4 Discussion and Conclusion ... 103
8 Summary, general discussion and future work ... 109
9 Samenvatting, algemene discussie en verder onderzoek ... 117
PhD portfolio and Curriculum Vitae ... 125
