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VU Research Portal

B-vitamins for the prevention of fractures and decline of physical function

Swart-Polinder, C.M.A.

2015

document version

Publisher's PDF, also known as Version of record

Link to publication in VU Research Portal

citation for published version (APA)

Swart-Polinder, C. M. A. (2015). B-vitamins for the prevention of fractures and decline of physical function.

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Contents

Chapter 1 9 General introduction Chapter 2 21

Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B12 and folic acid on fracture incidence

Chapter 3 41

Cross-sectional and longitudinal association between homocysteine, vitamin B12 and physical performance in older persons

Chapter 4 59

Elevated homocysteine levels are associated with low muscle strength and functional limitations in older persons

Chapter 5 77

Homocysteine and the methylenetetrahydrofolate reductase 677C→T polymorphism in relation to muscle mass and strength, physical performance and postural sway

Chapter 6 95

High circulating folate concentrations are associated with low-grade inflammation: an explanation for the homocysteine paradox?

Chapter 7 109

Effect of daily vitamin B12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine level: B-PROOF, a randomized controlled trial

Chapter 8 131

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Chapter 9 149 Effect of vitamin B12 and folic acid supplementation on bone mineral density and

quantitative ultrasound parameters in older people with an elevated plasma homocysteine level: B-PROOF, a randomized controlled trial

Chapter 10 169 General discussion Summary 193 Samenvatting 199 Acknowledgements 205 Dankwoord

About the author 211

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VU Research Portal

To our best knowledge, the B-PROOF study is the first intervention study in which the effect of vitamin B12 and folic acid supplementation on osteoporotic fractures is