Matrix metalloproteinases in inflammatory bowel disease : expression, regulation and clinical relevance
Meijer, M.J.W.
Citation
Meijer, M. J. W. (2009, April 23). Matrix metalloproteinases in inflammatory bowel disease : expression, regulation and clinical relevance. Retrieved from https://hdl.handle.net/1887/13749
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Matrix Metalloproteinases in Inflammatory Bowel Disease
Expression, Regulation and Clinical Relevance
Martin Jan-Willem Meijer
ISBN: 978-90-9024077-0
Printed by Gildeprint Drukkerijen B.V., Enschede, The Netherlands
© M.J.W. Meijer, Zeist 2009
No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical including photocopy, recording or any information storage and retrieval system, without prior written permission from the author.
The work described in this thesis was performed at the Department of Gastroenterology and Hepatology of the Leiden University Medical Center (Leiden, The Netherlands). The project was partly financed by a grant from the Netherlands Digestive Diseases Foundation (WS 98-17)
Printing of this thesis was financially supported by the Section Experimental Gastroenterology (SEG) of the Netherlands Society of Gastroenterology (NVGE).
Matrix Metalloproteinases in Inflammatory Bowel Disease
Expression, Regulation and Clinical Relevance
PROEFSCHRIFT
ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 23 april 2009
klokke 16.15 uur
door
Martin Jan-Willem Meijer geboren te Amsterdam
in 1974
Promotiecommissie :
Promoter: Prof. dr. C.B.H.W. Lamers Co-promoter: Dr. ir. H.W. Verspaget
Referent: Prof. dr. A.S. Peña, Vrije Universiteit Amsterdam Overige leden: Prof. dr. A. van der Laarse
Prof. dr. P.H.A. Quax
Prof. dr. D.W. Hommes
Dr. R.A. van Hogezand
Contents
Abbreviations 7
Chapter 1 Introduction
9
Chapter 2
Expression of matrix metalloproteinases-2 and -9 in intestinal tissue of patients with inflammatory bowel disease (IBD)
Dig Liver Dis 2005; 37: 584-592
57
Chapter 3
Effect of the anti-tumor necrosis factor-Į antibody infliximab on the ex vivo mucosal matrix metalloproteinase-proteolytic phenotype in inflammatory bowel disease (IBD)
Inflamm Bowel Dis 2007; 13: 200-210
79
Chapter 4
Infliximab treatment influences the serological expression of matrix metalloproteinase (MMP)-2 and-9 in Crohn’s disease Inflamm Bowel Dis 2007; 13: 693-702
111
Chapter 5
Increased mucosal matrix metalloproteinase-1, -2, -3 and -9 activity in patients with inflammatory bowel disease and the relation with Crohn’s disease phenotype
Dig Liver Dis 2007; 39: 733-739
135
Chapter 6
Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-Į single nucleotide gene polymorphisms in inflammatory bowel disease
World J Gastroenterol 2007; 13: 2960-2966
153
Chapter 7
Matrix metalloproteinases and their tissue inhibitors as prognostic indicators for diagnostic and surgical recurrence in Crohn’s disease Inflamm Bowel Dis 2009; 15: 84-92
173
Chapter 8
Summarizing discussion
193
Chapter 9
Nederlandse samenvatting Nawoord
Curriculum vitae
209
Abbreviations
APMA p-amino-phenyl-mercuric acetate
ARMS Amplification refractory mutational system BIA Bio-immuno activity assay
CD Crohn’s disease CI Confidence interval CRC Colorectal carcinoma DSS Dextran sodium sulphate ECM Extracellular matrix
ELISA Enzyme-linked immunosorbent assay HR Hazard ratio
IBD Inflammatory bowel disease IFN Interferon
IL Interleukin
HRP Horse radish peroxidase kDa Kilo Dalton
LPS Lipopolysaccharide MMP Matrix metalloproteinase MPO Myeloperoxidase NS Not significant
PMNL Polymorphonuclear leukocyte PWM Pokeweed mitogen
RFLP Restriction fragment length polymorphism RT-PCR Reverse transcription polymerase chain reaction SEM Standard error of the mean
SNP Single nucleotide polymorphism TGF Transforming growth factor
TIMP Tissue inhibitor of metalloproteinases TNF Tumor necrosis factor
UC Ulcerative colitis
