Improving the quality of oral anticoagulant therapy
Gadisseur, A.P.A.
Citation
Gadisseur, A. P. A. (2006, June 21). Improving the quality of oral anticoagulant therapy.
Retrieved from https://hdl.handle.net/1887/4455
Version:
Corrected Publisher’s Version
License:
Licence agreement concerning inclusion of doctoral thesis in the
Institutional Repository of the University of Leiden
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IMPROVING THE QUALITY
OF
ORAL ANTIC OAGULANT THERAPY
IMPROVING THE QUALITY
OF
ORAL ANTICOAGULANT THERAPY
PROEFS CHRIFT
ter v erk rijg ing v an
de g raad v an D oc tor aan de Univ ersiteit Leiden, op g ez ag v an de Rec tor Mag nific us D r. D .D . B reim er,
h oog leraar in de fac ulteit der W isk unde en Natuurw etensc h ap p en en die der Geneesk unde,
v olg ens b esluit v an h et Colleg e v oor Prom oties te v erdedig en op w oensdag 2 1 juni 2 0 0 6
k lok k e 1 6 .1 5 uur
door
Alain Peter Anton Gadisseur
PROMOTIECOMMISSIE
Promotor: Prof. dr. F.R. Rosendaal
C o-p romotor: Dr. F.J.M. van der Meer
R e fe re n t: Prof. dr. M.M. Levi
(AMC – UvA te Amsterdam)
ISBN nummer: ISBN-10: 90-90207 65-1 ISBN-13 : 97 8 -90-90207 65-0
Publication of this thesis was supported by Bayer Healthcare, Roche and AMGEN.
CONTENTS
Chapter 1 General Introduction . . . . 9
Chapter 2 Therapeutic q uality control of oral anticoagulant therapy . . . . 23
comparing the short-acting acenocoumarol and the long-acting phenprocoumon Chapter 3 Comparison of control and stability of oral anticoagulant therapy . . . . 37
using acenocoumarol versus phenprocoumon Chapter 4 Comparison of the q uality of oral anticoagulant therapy through . . . . 51
patient self-management versus management by specialized anticoagulation clinics in the Netherlands: a randomized clinical trial. Chapter 5 Patient self-management of oral anticoagulant care versus . . . . 71
management by specialized anticoagulation clinics: positive effects on Quality of Life. Chapter 6 Sustained intake of paracetamol (acetaminophen) during oral . . . . 87
anticoagulant therapy with coumarins does not cause clinically important INR changes: a randomized double blind clinical trial. Chapter 7 The q uality of oral anticoagulant therapy and recurrent . . . . 97
venous thrombotic events in the Leiden Thrombophilia Study (LETS). Chapter 8 General discussion and Summary . . . . 111
Chapter 9 Samenvatting . . . . 119
Cu rric u lu m V itae . . . 130
