Cardiac bone marrow cell injection for chronic ischemic heart disease Beeres, S.L.M.A.

Cardiac bone marrow cell injection for chronic ischemic heart

disease

Beeres, S.L.M.A.

Citation

Beeres, S. L. M. A. (2007, October 17). Cardiac bone marrow cell injection for chronic

ischemic heart disease. Department of Cardiology, Faculty of Medicine, Leiden

University Medical Center (LUMC), Leiden University. Retrieved from

https://hdl.handle.net/1887/12421

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in

the Institutional Repository of the University of Leiden

Cardiac Bone Marrow Cell Injection for

Chronic Ischemic Heart Disease

Monique R.M. Jongbloed

Medical Center, Leiden, the Netherlands.

Copyright © 2007 Saskia L.M.A. Beeres, Leiden, the Netherlands. All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, without prior written permission of the author.

Layout: Buijten & Schipperheijn, Amsterdam, The Netherlands.

Printed by: Buijten & Schipperheijn, Amsterdam, The Netherlands.

ISBN: 978-90-9022211-0

Cardiac Bone Marrow Cell Injection for

Chronic Ischemic Heart Disease

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden,

op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,

volgens besluit van het College voor Promoties

te verdedigen op woensdag 17 oktober 2007

klokke 16.15 uur

door

Saskia Lambertha Maria Anna Beeres

geboren te Leidschendam

in 1979

Promotiecommissie

Promotores: prof. dr. M.J. Schalij

prof. dr. J.J. Bax

Co-promotor: dr. D.E. Atsma

Referent: prof. dr. P.A.F.M. Doevendans (Universitair Medisch Centrum, Utrecht)

Overige leden: prof. dr. R.N.W. Hauer (Universitair Medisch Centrum, Utrecht)

prof. dr. E. E. van der Wall

prof. dr. W.E. Fibbe

prof. dr. A.C. Gittenberger-de Groot

dr. K. Zeppenfeld

Voor mijn ouders

Aan Paul

Table of Contents

Chapter 1 General introduction

Chapter 2 Human adult bone marrow mesenchymal stem cells repair

experimental conduction block in rat cardiomyocytes cultures

Journal of the American College of Cardiology 2005;46:1943-1952

Chapter 3 Feasibility of trans-endocardial cell transplantation in chronic

ischemia

Heart 2007;93:113-114

Chapter 4 Electrophysiological and arrhythmogenic effects of intramyocardial

bone marrow cell injection in patients with chronic ischemic heart

disease

Heart Rhythm 2007;4:257-265

Chapter 5 Intramyocardial bone marrow cell transplantation and the progression

of coronary atherosclerosis in patients with chronic myocardial

ischemia

Acute Cardiac Care 2007 in press

Chapter 6 Usefulness of intramyocardial injection of autologous bone marrow-

derived mononuclear cells in patients with severe angina pectoris

and stress-induced angina pectoris

American Journal of Cardiology 2006;97:1326-1331

Chapter 7 Effect of intramyocardial bone marrow cell injection on diastolic

function in patients with chronic myocardial ischemia

Journal of Magnetic Resonance Imaging 2007 in press

Chapter 8 Effect of intramyocardial injection of autologous bone marrow-

derived mononuclear cells on perfusion, function and viability in

patients with drug-refractory chronic ischemia

Journal of Nuclear Medicine 2006;47:574-580

8

38

56

64

84

102

116

130

Chapter 10 Intramyocardial injection of autologous bone marrow mononuclear

cells in patients with chronic myocardial infarction and severe left

ventricular dysfunction

American Journal of Cardiology 2007 in press

Chapter 11 Role of Imaging in Cardiac Stem Cell Therapy

Journal of the American College of Cardiology 2007;49:1137-1148

Summary, conclusions and future perspectives

Samenvatting, conclusies en toekomstperspectieven

List of publications

Acknowledgements

Curriculum vitae

160

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