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The handle http://hdl.handle.net/1887/18948 holds various files of this Leiden University dissertation.

Author: Boers, Kim Esther

Title: Strategies in intrauterine growth restriction at term

Issue Date: 2012-05-16

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Strategies in Intrauterine Growth Restriction At Term

Kim E. Boers

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The author acknowledges financial support for printing this thesis by:

Bronovo Research Fonds

Strategies in Intrauterine Growth Restriction At Term Thesis, Leiden University, The Netherlands

ISBN 9789461082985

Author Kim E. Boers Cover design Janneke Smilde Design Janneke Smilde

Printed by Gildeprint Drukkerijen, Enschede

Copyright © 2012 K.E. Boers

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Strategies in Intrauterine Growth Restriction At Term

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. Van der Heijden,

volgens besluit van het College voor Promoties te verdedigen op

woensdag 16 mei 2012 klokke 16:15 uur

door

Kim Esther Boers

geboren te Rotterdam

in 1972

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Promotores: Prof. Dr. J.M.M. van Lith

Prof. Dr. B.W.J. Mol (Universiteit van Amsterdam)

Copromotores: Dr. S.A. Scherjon Dr. S. le Cessie

Commisie: Prof. J.G. Thornton (University of Nottingham)

Prof. Dr. C.J.M. de Groot ( Vrije Universiteit van Amsterdam)

Dr. F. J. M. E. Roumen (Atrium Medisch Centrum Heerlen)

Prof. Dr. F.J. Walther

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Voor Jan Willem, Tim, Anne Jet en Hidde

Aan mijn moeder

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Table of contents

Chapter 1

General Introduction and outline of the thesis

Chapter 2

Labour and neonatal outcome in small for gestational age babies delivered beyond 36+0 weeks: a retrospective cohort study.

Chapter 3

Disproportionate Intrauterine Growth Intervention Trial At Term: DIGITAT-the protocol.

Chapter 4

Induction versus expectant monitoring for intrauterine

growth restriction at term: randomised equivalence trial (DIGITAT)

Chapter 5

Neonatal morbidity after induction versus expectant monitoring in intrauterine growth restriction at term: a subanalysis

of the DIGITAT RCT

Chapter 6

Comparison of participants and non-participants in a trial of induction versus expectant monitoring for intrauterine growth restriction at term (the DIGITAT trial)

Chapter 7

Maternal health-related quality of life after induction of labor

11

33

45

59

79

95

109

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management for intrauterine growth restriction at term (DIGITAT trial)

Chapter 9

Effects on (neuro)developmental and behavioural outcome at 2 years of age of induced labour compared with expectant management in intrauterine growth restricted infants - long term outcomes

of the DIGITAT-trial.

Chapter 10

Comparison of induction of labour and expectant monitoring in intrauterine growth restriction at term through integration of trial outcomes and patient preferences

Chapter 11

Suspected versus non-suspected small-for-gestational age fetuses at term: perinatal outcomes.

Chapter 12

General Discussion and future perspectives

Chapter 13 Summary

Chapter 14

Nederlandse samenvatting

141

157

171

191

205

221

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