The handle http://hdl.handle.net/1887/20223 holds various files of this Leiden University dissertation.
Author: Spijker, Anne Titia
Title: Cortisol exposure, cognition and clinical course of bipolar disorder Issue Date: 2012-12-04
Cortisol exposure, cognition
and clinical course of bipolar disorder
A.T. Spijker
Cortisol exposure, cognition
and clinical course of bipolar disorder
Proefschrift
Ter verkrijging van de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus Prof. Mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op dinsdag 4 december 2012 klokke 13:45 uur
door
Anne Titia Spijker
Geboren te Rotterdam in 1975
Overige leden: Prof. Dr. W. A. Nolen (UMCG)
Prof. Dr. R. W. Kupka (VUmc, Amsterdam) Prof. Dr. E. R. De Kloet
This research project was financially supported by Fonds Nuts Ohra, PsyQ The Hague and the Parnassia Group.
Printing of this thesis was financially supported by the Parnassia Bavo Academie and the Faculty of Social Sciences, Leiden University.
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Content
Chapter 1. Introduction 7
Chapter 2. Glucocorticoid sensitivity in Mood Disorders 43
Chapter 3. Glucocorticoid Receptor Polymorphisms in Major Depression:
Focus on glucocorticoid sensitivity and neurocognitive functioning 63
Chapter 4. Functional Polymorphism of the Glucocorticoid Receptor Gene
associates with mania and hypomania in Bipolar Disorder 93
Chapter 5. Glucocorticoid and mineralocorticoid receptor polymorphisms
and clinical characteristics in bipolar disorder patients 109
Chapter 6. Long-term cortisol in Bipolar Disorder: Associations with age of
onset and psychiatric comorbidity 131
Chapter 7. Influence of medication use and clinical characteristics of Bipolar Disorder on attention, working memory and executive functions 153
Chapter 8. Discussion 175
Summary 197
Nederlandstalige samenvatting 207
Curriculum Vitae 215
Dankwoord 219
