The embarrassed brain : towards a neurobiology of generalized socal anxiety disorder
Veen, J.F. van
Citation
Veen, J. F. van. (2010, October 28). The embarrassed brain : towards a neurobiology of generalized socal anxiety disorder. Retrieved from https://hdl.handle.net/1887/16086
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THE EMBARRASSED BRAIN
Towards a neurobiology of generalized social anxiety disorder
Frederieke van Veen
Frederieke van Veen
THE EMBARRASSED BRAIN
Fotography cover: Froukje van der Zanden - Alba Fotografie
Print and design: GVO drukkers & vormgevers B.V. | Ponsen & Looijen, Ede, The Netherlands The studies in chapter 5, 6 and 7 were financed by ZonMw, The Hague, The Netherlands.
Printing of this thesis was financially supported by GGZ Leiden (Rivierduinen Mental Health Center), MSD, Janssen-Cilag B.V., Lundbeck B.V., Eli Lilly Nederland B.V., Servier Nederland Farma B.V., and Pfizer B.V.
© 2010 J.F. van Veen, Leiden, The Netherlands
CU-COC-805712 D-02
THE EMBARRASSED BRAIN
Towards a neurobiology of generalized social anxiety disorder
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 28 oktober 2010
klokke 16.15 uur
door
Jantien Frederieke van Veen geboren te Utrecht
in 1974
Promotiecommissie
Promotor: Prof. dr. F.G. Zitman Copromotores: Dr. I.M. van Vliet
Dr. R.H. De Rijk
Overige leden: Prof. dr. E.R. de Kloet
Prof. dr. J.M.A. van Gerven
Prof. dr. P.M. Westenberg
Voor Rachel en Sofie
Contents
CHAPTER 1
Introduction ... 9
CHAPTER 2 Behavioural effects of rapid intravenous administration of meta-chlorophenylpiperazine (m-CPP) in patients with generalized social anxiety disorder, panic disorder and healthy controls ... 21
CHAPTER 3 Increased serotonin and dopamine transporter binding in psychotropic medication-naive patients with generalized social anxiety disorder shown by 123I-ß-(4-iodophenyl)-tropane SPECT... 33
CHAPTER 4 Mirtazapine in social anxiety disorder: a pilot study ... 49
CHAPTER 5 Elevated alpha-amylase but not cortisol in generalized social anxiety disorder ... 57
CHAPTER 6 Tryptophan depletion affects the autonomic stress response in generalized social anxiety disorder ... 73
CHAPTER 7 The effects of female reproductive hormones in generalized social anxiety disorder ... 83
CHAPTER 8 Summary and discussion ... 95
CHAPTER 9 Nederlandse samenvatting en discussie ...111
Dankwoord ...118
List of Publications ...120
Curriculum Vitae ...121
Abbreviations ...122
