Bijvoet Center

Bijvoet Center

for Biomolecular Research

Progress Report 2014-2015

“Discovering the Molecular Basis of Life”

Table of Contents

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Dr. Reinout Raijmakers

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Contact Details

Postal address

Bijvoet Center for Biomolecular Research Padualaan 8

Utrecht University

Padualaan 8 (room O604) 3584 CH Utrecht

The Netherlands

Contact details Dr. Reinout Raijmakers Managing Director

Bijvoet Center for Biomolecular Research Tel.: +31 30 253 6804

E-mail: R.Raijmakers@uu.nl Science.Bijvoet@uu.nl

Website Bijvoet Center www.bijvoet-center.eu

Website PhD programme MLS www.bijvoet-center.eu/phd-programme/

Executive Board

Prof. dr. M. Baldus (Scientific Director) Prof. dr. A.J.R. Heck

Prof. dr. P. Gros Prof. dr. I. Braakman Prof. dr. A. Killian Prof. dr. G.J. Boons

Dr. R. Raijmakers (Managing Director)

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Prof.dr. J.F.G. Vliegenthart (chairman) Emeritus of Utrecht University, NL Prof.dr. A. Bax

NIH, Bethesda, USA Prof.dr. J. Johnson,

The Scripps Research Institute, La Jolla, USA Prof.dr. K. Wilson

University of York, UK

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Design by Reinout Raijmakers, photography by Ivar Pel,

Bas van Breukelen, Reinout Raijmakers, and others.

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Figure: Illustration of the distribution of microtubule minus ends labeled with CAMSAP2 and microtubule plus ends labeled with EB1 in Hela cells (the two microtubule end markers are shown in green, microtubules in red). A scheme illustrating the accumulation of CAMSAP2 and EB1 at the two dynamic microtubule ends is shown below.

Anna Akhmanova studied biochemistry and molecular biology at the Moscow State University. She received her PhD in 1997 at the University of Nijmegen.

She worked as a post-doc at the Depart- ment of Microbiology and Evolutionary Biology at the University of Nijmegen and at the Department of Cell Biology at the Erasmus Medical Center in Rot- terdam. In 2001, she has started her own research group at the Department of Cell Biology at the Erasmus Medical Center.

Since 2011, Anna Akhmanova is profes- sor of Cell Biology at Utrecht Universi- ty. Anna Akhmanova is a recipient of the ALW Vernieuwingsimpuls VIDI (2001) and VICI awards (2007), and an ERC Synergy grant (2013). She is a member of the European Molecular Biology Or- ganization (EMBO), the Royal Neth- erlands Academy of Arts and Sciences (KNAW) and the Chair of the board of the Netherlands Society for Microscopy.

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Maarten Altelaar studied analytical chemistry at the Vrije Universiteit (VU) in Amsterdam, where he received his Masters degree in July 2002. In May 2002 he started a PhD under at the FOM-Institute for Atomic and Mo- lecular Physics (AMOLF). Topic of his research was the development of meth- odology for imaging mass spectrometry, mapping biomolecular distributions di- rectly from single cell and tissue surfaces.

In March 2007 he received his PhD after which he joined the Biomolecular Mass Spectrometry and Proteomics group at the University of Utrecht. Here the fo- cus of his research switched to more proteomics based techniques, with the emphasis on quantitation, electron trans- fer dissociation (ETD) and cancer and neuroproteomics. Maarten is currently appointed as associate professor at the Utrecht University and in 2013 received an NWO VIDI award on a proposal named Network Medicine; Quantifying Proteome Wide Crosstalk, aimed at the development of proteomics methodology for the quantitative analysis of protein- protein interactions, PTMs and protein signaling networks in the face of their interconnectivity, in BRAF mutant mel- anoma drug resistance.

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Marc Baldus obtained his Ph.D. from ETH Zürich in 1996 and worked as postdoctoral research associate at MIT, Cambridge/USA. (1997-1999). After a university Lecturership at the Leiden Institute of Chemistry, he became group leader at the Max-Planck-Institute for Biophysical Chemistry in Göttingen in 2000. He returned to the Netherlands to become full Professor of Structural Biology (2008) at Utrecht University and has been heading its NMR section since 2010. He received the Founders Medal of the International Council on Magnetic Resonance in Biological Sys- tems (ICMRBS) in 2006, the EBSA prize of the Association of the Euro- pean Biophysical Societies (2007) and the Günther Laukien Prize (2014). He acquired NWO VICI and NWO-groot (2010) funding as well as an NWO Top-punt grant (2015, with A. Bon- vin) to conduct NMR-based research at the interface of structural and cellular biology. Since 2012, he coordinates the NWO Roadmap project uNMR-NL to set up a 1.2 GHz NMR facility for the Netherlands. Phase 1 of this project, i.e., installation of a 950 MHz NMR in Utrecht, was completed in November 2015. Since April 2016, he is scientific director of the Bijvoet Center.

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Celia Berkers studied chemistry at Utre- cht University, where she graduated cum laude in 2003. She started her PhD at the Harvard Medical School in Boston and continued her research at the Neth- erlands Cancer Institute in Amsterdam.

Berkers received her PhD degree with honors in 2010 and was awarded the Antoni van Leeuwenhoek Prize 2010 for most promising young scientist. She then moved to the Beatson Institute for Can- cer Research in Glasgow, where she did a post-doc in the laboratory of Prof. Karen Vousden, supported by a Rubicon fellow- ship from NWO. In 2013, Dr Berkers joined the Biomolecular Mass Spectrom- etry and Proteomics Department at Utrecht University as an independent group leader and was awarded a VENI grant from NWO-CW. In 2014, she was awarded the Heineken Young Scientists Award for Biochemistry and Biophysics by the Royal Netherlands Academy of Arts and Sciences.

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Rolf Boelens

Rolf Boelens studied physical chem- istry at the University of Gronin- gen (Netherlands) and completed his Ph.D. in the Department of Bio- chemistry of the University of Am- sterdam. For a postdoc he went to the NMR group of Robert Kaptein.

Currently he is professor of biomo- lecular NMR spectroscopy and head of the Department of Chemistry.

He is director of the European high- resolution NMR facility at Utrecht University and coordinates the Eu- ropean program iNEXT, a Research Infrastructure for NMR, EM and X- rays for Translational research. His research interests are biomolecular recognition, dynamics and function with on an emphasis on transcription and DNA repair involved in DNA transcription and DNA repair. This research is complemented by develop- ing methods for biomolecular NMR.

His research has resulted in over 340 publications.

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