University of Groningen
Physical frailty in late-life depression: evidence for a depression-frailty subtype?
Arts, Matheus
DOI:
10.33612/diss.147370083
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Publication date: 2020
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Citation for published version (APA):
Arts, M. (2020). Physical frailty in late-life depression: evidence for a depression-frailty subtype?. University of Groningen. https://doi.org/10.33612/diss.147370083
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PPhhyyssiiccaall ffrraaiillttyy iinn llaattee--lliiffee ddeepprreessssiioonn::
Physical frailty in late-life depression: evidence for a depression-frailty subtype? Thesis, University of Groningen, The Netherlands
ISBN 978-94-6416-297-4 Author: Matheus H.L. Arts
Cover and lay-out: Sander Drooglever; Xandro Media www.xandro.nl / Radboud Wanders; www.zoom-artist.com www.digitale-karikaturist.nl / Sandra Tukker, Ridderprint / Linda de Jonge
Printed by Ridderprint, www.ridderprint.nl Copyright © M.H.L. Arts, Groningen 2020
No part of this thesis may be reproduced, stored in a retrieval center of any nature, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the permission of the author.
Funding for studies: The infrastructure for the NESDO was funded through the Fonds NutsOhra, Stichting tot Steun VCVGZ, NARSAD The Brain and Behaviour Research Fund, and the participating universities and mental health care organizations. The Older Persons with Medically Unexplained Symptoms (OPUS) study was supported by the National Care of the Elderly Program , as part of the Netherlands Organisation for Health Research and Development (ZonMW) [grant number 60-61900-98-425 ].
Financial support for printing this thesis is gratefully acknowledged from the following institutions: SHARE, University of Groningen, University Medical Center Groningen.
Physical frailty in late-life depression:
evidence for a depression-frailty subtype?
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 21 december 2020 om 14.30 uur
door
Matheus Hendrikus Leonardus Arts
geboren op 9 juni 1971 te Arnhem
PPrroommoottoorr
Prof. dr. R.C. Oude Voshaar CCoopprroommoottoorreess Dr. H.C. Comijs Dr. L. de Jonge BBeeoooorrddeelliinnggssccoommmmiissssiiee Prof. dr. F. Bouckaert Prof. dr. E. Buskens Prof. dr. M.L. Stek
PPaarraanniimmffeenn Philip Michielsen Sergei Petrykiv
“Cause I’m only a Crack
in this Castle of Glass
hardly Anything there
for You to See”
To my mum Emmy
CCoonntteennttss
Chapter 1 General introduction 10
PPaarrtt II:: AAggeeiinngg--rreellaatteedd bbiioommaarrkkeerrss ooff pphhyyssiiccaall ffrraaiillttyy iinn llaattee--lliiffee ddeepprreessssiioonn
Chapter 2 The relation between physical frailty and low-grade inflammation in late-life depression
J Am Geriatr Soc 2015;63:1652-1657.
42
Chapter 3 Telomere length and physical frailty in late-life depression
Exp Gerontol 2018;111:229-234. 62
Chapter 4 Vitamin D deficiency and course of frailty in a depressed older population
Aging Ment Health 2018;15:1-7.
88
PPaarrtt IIII:: AAssssoocciiaattiioonnss bbeettwweeeenn pphhyyssiiccaall ffrraaiillttyy aanndd ccoommmmoonn ((nneeuurroo))ppssyycchhiiaattrriicc ssyymmppttoommss
Chapter 5 Physical frailty and cognitive functioning in depressed older adults: Findings from the NESDO study
J Am Med Dir Assoc 2016;17:1652-1657.
116
Chapter 6 Frailty and somatic comorbidity in older patients with medically unexplained symptoms
J Am Med Dir Assoc. 2019;20:1150-1155
146
PPaarrtt IIIIII:: AAddvveerrssee hheeaalltthh oouuttccoommeess ooff pphhyyssiiccaall ffrraaiillttyy iinn llaattee--lliiffee ddeepprreessssiioonn
Chapter 7 The impact of frailty on depressive disorder in later life: Findings from the Netherlands Study of depression in older persons
European Psychiatry 2017;43:66-72.
172
Chapter 8 Frailty predicts mortality in late-life depression
J Clin Psychiatry 2020 accepted 202
Chapter 9 Summary and general discussion 228
Chapter 10 Summary in Dutch 264
Chapter 11 Acknowledgments 288
About the author 291
List of publications 295
List of recent SHARE theses Notes
310 312
