University of Groningen
Global players with local impact
Nagy, Sandra
DOI:
10.33612/diss.132814240
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Nagy, S. (2020). Global players with local impact: Novel biomarkers for fertility. University of Groningen. https://doi.org/10.33612/diss.132814240
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Propositions
These propositions belong to the PhD thesis entitled
GLOBAL PLAYERS WITH LOCAL IMPACT
Novel biomarkers for fertility
1. Bile acids enter ovarian follicular fl uid from blood through passive and active transport regulated by the classic bile acid transporters NTCP, ASBT, ABCC3 on granulosa cells. (This thesis)
2. The presence of bile acid transporters on the oocyte and of nuclear receptors involved in bile acid signaling on granulosa cells argues in favor of a physiologically relevant role of bile acids in oocyte development. (This thesis)
3. Follicular fl uid bile acids are associated with oocyte and embryo development: ursodeoxycholic acid is prospectively associated with embryo quality and cell number, while chenodeoxycholic acid and deoxycholic acid are prospectively associated with embryo fragmen-tation. (This thesis)
4. Follicular fl uid high density lipoproteins exert anti-oxidative and anti-infl ammatory functions that are relevant for oocyte and em-bryo development. (This thesis)
5. Follicular fl uid levels of trimethylamine-N-oxide and its gut-de-rived precursor gamma-butyrobetaine are negatively associated with oocyte fertilization and embryo quality, indicating that a part of the eff ect of diet on fertility is likely mediated by metabolites generated by the gut microbiota. (This thesis)
6. It is necessary that at least once in your life you doubt, as far as possible, all things. [ r = a (1-sin θ) ] (René Descartes)
Groningen, 23rd of September 2020
Ruxandra A. Nagy
stellingen_Sandra.indd 1
