University of Groningen
Low-normal thyroid function and cardio-metabolic risk markers
Wind, Lynnda
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Publication date: 2018
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Wind, L. (2018). Low-normal thyroid function and cardio-metabolic risk markers. Rijksuniversiteit Groningen.
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Low-normal thyroid function and
cardio-metabolic risk markers
Colofon
Low-normal thyroid function and cardio-metabolic risk markers
Dissertation University of Groningen ISBN: 978-94-028-1158-2 (printed version) ISBN: 978-94-034-1019-7(electronic version) © 2018 Lynnda van Tienhoven-Wind
All rights reserved. No part of this publication may be reproduced, stored in a retrieval sytem, or transmitted in any form or by any means, mechanically by photocopying, recording, or otherwise, without the written permission of the author.
Design: L.S. Uspessij - luvormgeving.nl Cover image: chromatos/Shutterstock.com Printing: Ipskamp printing - Enschede
Low-normal thyroid function and
cardio-metabolic risk markers
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 31 oktober 2018 om 12:45 uur
door
Lynnda Joan Naômi Wind
Promotores
Dr. R.P.F. Dullaart Prof. dr. R.O.B. Gans
Beoordelingscommissie
Prof. dr. S.J.L. Bakker Prof. dr. T.P. Links Prof. dr. R.P. Peeters
Paranimfen
Shirly H. Klein Marleen van Oosten
Table of contents
Chapter 1. General introduction and aims of this thesis 8
Chapter 2. Low-normal thyroid function and the pathogenesis of 16
common cardio-metabolic disorders: Review. Eur J Clin Invest 2015;45:494-503.
Chapter 3. Low normal thyroid function as a determinant of increased 34
large very low density lipoprotein particles. Clin Biochem 2015;48:489-494.
Chapter 4. Higher plasma apoE levels are associated with low-normal 52
thyroid function: Studies in diabetic and nondiabetic subjects. Horm Metab Res 2016;48:462-467.
Chapter 5. Pre β-HDL formation relates to high-normal free thyroxine in 66
type 2 diabetes mellitus. Clin Biochem 2016;49:41-46.
Chapter 6. Serum paraoxonase-1 activity is inversely related to free 83
thyroxine in euthyroid subjects. Eur J Clin Invest 2018;48:e12860.
Chapter 7. Tumor necrosis factor-α is inversely related to free thyroxine in 100
euthyroid subjects without diabetes. Horm Metab Res 2017;49:95-102.
Chapter 8. Increased leptin/adiponectin ratio relates to low-normal thyroid 116
function in metabolic syndrome. Lipids in Health and Disease 2017;16:6.
Chapter 9. Higher free triiodothyronine is associated with non-alcoholic fatty 131
liver disease in euthyroid subjects: The Lifelines Cohort Study. Metabolism 2017;67:62-71.
