SPECTRAL DATA:INFRARED, MASS SPECTROMETRY,ANDNUCLEAR MAGNETIC RESONANCE

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APPENDIX i

SPECTRAL DATA:

INFRARED, MASS SPECTROMETRY,

AND

NUCLEAR MAGNETIC RESONANCE

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APPENDIX I

INFRARED

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APPENDIX!

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■Spectrum 1j

Spectrum

2

106

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APPENDIX § i i 4000 3600 Student* w n p l w

Spectrum 3:

i i i i i i i i i i i i i i i i i i i i i i i i I i i i i i i i i ' i i i i i i ' ' ' ' i * ' ' ' i ' * * ' i 4 0 0 0 3 4 0 0 3 2 0 0 2 8 0 0 2400 2 0 0 0 1 8 0 0 1S00 1400 1203 1000 800 Student* tampan 1fc">

ISpectrum 4!

107

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A P P E N D I X i 1_{• * i '} i_■_{• i} 4000 3000 3200 Slud*nt« w i p l m

!Spectrum 5:

S p e c t r u m 6:

108

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iSpectrum 7i

■Spectrum 8!

109

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APPENDIX i

MASS SPECTROMETRY

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APPENDIX i 1 0 0 k 95.: 90J 85.; 80^ 75J 70J 63'. 6 0 i 5 5 j SOi 4 5 i 4 0 . 3 5 i 3 0 i 25„-5 0 . I S j j 1 0 . si 0^ 1 5 8 I H,C3V HO 2 7 1 1 6 13 5 1 7 1 ilU.~ ■! 1 4 3 1 5 3 1 2 9 1 6 9 1 8 6 18 i a a 1 9 9 1B7 2 1 4 23 3 40 60 80 1 0 0 1 2 0 1 4 0 1 6 0 1 8 0 2 0 0

.Spectrum 9,

^ 4 . 4 E 6 4 . 1E6 L 3 - 9 E 6 L 3 . 7 E 6 L 3 . 5 E 6 L 3 . 3 E 6 L 3 . 1 E 6 L 2 . 8 E 6 . 2 . 6E6 L 2 . 4 E 6 E.2.2E6 L 2 . 0 E 6 L l . 7 E 6 L 1 . 5 E 6 1 . 3 E 6 1 1 . 1 E 6 U . 7 E 5 , 6 . 5 E 5 4 . 4 E 5 L 2 . 2 E 5 O.OEO 2 6 0 1003c 9 5 j 9 0 i 8 5 i 8 0 i 7 5 i 7 0 i 6 5 i 6 0 i 5 5 i 5 0 i 4 5 i 4 0 j 3 5 i 3 0 i 2 5 i 2 0 i 1 5 J l O i 5 : 2 0 3 9 It ' -ll i , l M . l t .lilllil 196 183 129 51 66 1 6 5 j^rjQ 40 60 261 52 120 l.^ljlll^ , |ll,l|l. .til., ll, yl.ll .220 240 260 280

ISpectrum 10l

8 . 6 E 6 L.8.2E6 7 . 8 E 6 L 7 . 3 E 6 . 6 . 9 E 6 6 . 5 E 6 E.6.1E6 L 5 . 6 E 6 L.5.2E6 . 4 . 8E6 L 4 . 3 E 6 3 . 9 E 6 L 3 . 5 E 6 L 3 . 0 E 6 L 2 . 6E6. L.2.2E6 L l . 7 E 6 L 1 . 3 E 6 8 . 6 E 5 lA . 3E5 LO.OEO '300 ra/z 111

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APPENDIX i 100*, 95J 90,: 8 5 i 8 0 i 7 5 i 70 h 65.; 60ij 551 5 0 i 4 5 | 40_ 354 3 0 J 2 5 i ■2'Oj ioj 5 J

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114

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APPENDIX i

NUCLEAR MAGNETIC RESONANCE

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APPENDIX I

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APPENDIX I

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APPENDIX i

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APPENDIX I

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APPENDIX i

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APPENDIX

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APPENDIX i ;$:_{: S;} f CH CH

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ACKNOWLEDGEMENTS

/ dedicate this dissertation to Almighty God and to my parents, Lennon Paul Barber and Marilyn

Rose Barber. They have made it possible forme to have had this wonderful opportunity!!

4- May God's name be glorified by the work I have done. All glory and honour is His!!!

4> I just want to thank my parents for always being there for me when I needed them most!! I want to thank them for their unconditional love, support and comfort!!

4- To my sister, and all my family, a special thanks to you too!!

4 All my friends!!! You have made this the best time of my life and I would not have had it

any different!! The times I had with you guys are priceless!! Having each one of you in my life was a dream come true!! I especially want to say thank you to my closest friends: Olwen, Chucky, Sharlene, Hartseer, Jenny, Johan, Kenny, Fox, Lily & Atta. Elkeen van julle het dit vir my die moeite werd gemaak om te lewe, en julle het my lewe so volmaak gemaak soos wat dit kon wees. Julle het my laat groei as mens en julle maak my wie ek vandag is!! Ek dank God dat ek die geleentheid het om elkeen van julle te ken. Dankie vir julle ondersteuning en vriendskap, en vir die vreugde wat julle my lewe mee verryk het!!!

A- To my supervisor, Prof. Sarel. F. Malan. A very very special thanks. DankievirProf.se

advies, leiding, en al Prof, se ondersteuning!! Dankie dat ek met Prof, kon gepraat het as ek nodig gehad het, en dankie dat Prof my as navorser opgelei het soos wat prof het!!!! I am nowequiped!!!

4- I also want to give a special thanks to the following people that were involved in my research. Without them my research would not have been possible. Dr. Jacques Petzer (MAO-B), Dr. Lissinda du Plessis (Flow Cytometry), Sharlene Lowe (Cell cultivation and biological assays), Nellie Scheepers (Biological assays), Prof. Breytenbach (Chemistry knowledge), Sameul (Solvents) and all my collogues at the pharmaceutical chemistry department!!!

± For the proof reading of my disseration, I just want to give special thanks to Prof. Franci Jordaan. In this regard I also want to give a special thanks to Dr. Jacques Petzer. 4- My apologies to anyone whom I have forgotten to mention..