University of Groningen
Medication safety in patients with cirrhosis Weersink, Rianne
DOI:
10.33612/diss.99705129
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Publication date:
2019
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Citation for published version (APA):
Weersink, R. (2019). Medication safety in patients with cirrhosis. Rijksuniversiteit Groningen.
https://doi.org/10.33612/diss.99705129
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Download date: 28-06-2021
Medication Safety
in Patients with Cirrhosis
Rianne Antoinet Weersink
Colophon
Financial support for (printing of) this thesis was provided by ZonMw, the Health Base Foundation, the Dutch Digestive Foundation (MLDS), the Dutch Medicines Evaluation Board (CBG-MEB), het Nederlands Bijwerkingen Fonds, the Groningen Graduate School of Science and Engineering (GSSE), and the University of Groningen and this is gratefully acknowledged.
Cover Design: Design Your Thesis, www.designyourthesis.com Layout: Design Your Thesis, www.designyourthesis.com Printing: Ridderprint, www.ridderprint.nl
ISBN (electronic version): 978-94-034-1918-3 ISBN (printed version): 978-94-034-1919-0
© 2019, Rianne A. Weersink.
No part of this thesis may be reproduced or transmitted in any form or in any means without permission of the author. The copyright of previously published chapters of this thesis remains with the publisher.
Medication Safety in Patients with Cirrhosis
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op vrijdag 22 november 2019 om 14.30 uur
door
Rianne Antoinet Weersink
geboren op 2 maart 1990 te Tubbergen
Promotor Prof. dr. K. Taxis Copromotor Dr. S.D. Borgsteede
Beoordelingscommissie Prof. dr. J.G.W. Kosterink Prof. dr. R.A. de Man Prof. dr. H.G.M. Leufkens
Table of
Contents
1. General introduction 9
2. Developing practical guidance for safe medication use in patients with cirrhosis 2.1 Evaluating the safety and dosing of drugs in patients with liver cirrhosis by
literature review and expert opinion
25
2.2 Safe use of proton pump inhibitors in patients with cirrhosis 41 2.3 Altered pharmacokinetics of statins explain increased risk of rhabdomyolysis in
advanced cirrhosis
77
2.4 Evidence-based recommendations to improve the safe use of drugs in patients with liver cirrhosis
83
3. Medication safety in patients with cirrhosis: current practice
3.1 Prevalence of drug prescriptions and potential safety in patients with cirrhosis: a retrospective real-world study
107
3.2 Medication safety in patients with hepatic impairment: a survey of community pharmacists’ knowledge level and their practice in caring for these patients
123
4. Quality of information from pre- and post-marketing information sources on safe medication use in patients with cirrhosis
4.1 Evaluation of information in Summaries of Product Characteristics (SmPCs) on the use of a medicine in patients with hepatic impairment
145
4.2 Spontaneous adverse drug reaction reports for patients with cirrhosis: analysis of the nature, quantity and quality of the reports
167
5. General discussion 173
Summary Samenvatting Dankwoord List of publications About the author
203 207 213 217 221
