Pregnancy outcome in South Australia
Verburg, Petra
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Publication date:
2018
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Verburg, P. (2018). Pregnancy outcome in South Australia: Population and cohort studies. University of
Groningen.
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Appendix 1 – List of abbreviations
AAPC average annual percentage change AIx augmentation index
ATSI Aboriginal or Torres Strait Islander BMI body mass index
BP blood pressure
cBP central blood pressure cDBP central diastolic blood pressure CI confidence interval
cMAP central mean arterial pressure cPP central pulse pressure CS caesarean section
cSBP central systolic blood pressure CVD cardiovascular disease DBP diastolic blood pressure DoB date of birth
DOHaD developmental origins of health and disease FAR fetus-at-risk
FGR fetal growth restriction eDoC estimated date of conception ePTB early preterm birth
GDM gestational diabetes mellitus GH gestational hypertension GTT glucose tolerance test hCG human chorionic gonadotropin HDP hypertensive disorders of pregnancy hPL human placental lactogen
HR heart rate
HREC Human Research Ethics Committee
ISSHP International Society for the Study of Hypertension in Pregnancy IH intermittent hypertension
IUGR intrauterine growth restriction MAP mean arterial pressure NIH National Institutes of Health
nsPE preeclampsia without severe features pBP peripheral blood pressure
pDBP peripheral diastolic blood pressure PIHD pregnancy induced hypertensive disorders pMAP peripheral mean arterial pressure pPP peripheral pulse pressure PE preeclampsia
POU Pregnancy Outcome Unit
PP pulse pressure
PPROM preterm prelabor rupture of the membranes PROM prelabor rupture of the membranes pSBP peripheral systolic blood pressure
PTB preterm birth
PWV pulsed wave velocity RCT randomized controlled trial RR relative risk
RR M/F relative risk males versus females SA South Australia
SAPSC South Australian Perinatal Statistics Collection SBP systolic blood pressure
SBR supplementary birth record SD standard deviation SES socio-economic status SGA small for gestational age SNR signal-to-noise ratio
sPE preeclampsia with severe features sPTB spontaneous preterm birth
STOP Screening Tests to predict poor Outcomes of Pregnancy T2D type 2 diabetes
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Appendix 2 – Contributing authors and affiliations
Professor Dr. Gustaaf A. Dekker Robinson Research Institute University of Adelaide Adelaide, Australia Adelaide Medical School University of Adelaide Adelaide, Australia
Department of Obstetrics and Gynaecology Lyell McEwin Hospital
Elizabeth Vale, Australia
Professor Dr. Jan Jaap H. M. Erwich Department of Obstetrics and Gynaecology University Medical Center Groningen University of Groningen
Groningen, The Netherlands
Dr. Shalem Leemaqz Robinson Research Institute University of Adelaide Adelaide, Australia Adelaide Medical School University of Adelaide Adelaide, Australia
Drs. Emma McBean Robinson Research Institute University of Adelaide Adelaide Australia Adelaide Medical School University of Adelaide Adelaide Australia
Department of Obstetrics and Gynaecology Lyell McEwin Hospital
Elizabeth Vale, Australia
Professor Dr. Ben W. Mol Robinson Research Institute University of Adelaide Adelaide Australia Adelaide Medical School University of Adelaide Adelaide Australia
Department of Obstetrics and Gynaecology Lyell McEwin Hospital
Drs. Mylene E. Mulder Robinson Research Institute University of Adelaide Adelaide, Australia Adelaide Medical School University of Adelaide Adelaide, Australia
Department of Obstetrics and Gynaecology University Medical Center Groningen University of Groningen
Groningen, The Netherlands
Professor Dr. Claire T. Roberts Robinson Research Institute University of Adelaide Adelaide, Australia Adelaide Medical School
University of Adelaide Adelaide, Australia
Drs. Wendy Scheil Adelaide Medical School University of Adelaide Adelaide, Australia Epidemiology Branch
SA Health
Adelaide, Australia
Dr. Graeme Tucker Adelaide Medical School University of Adelaide Adelaide, Australia Epidemiology Branch
SA Health
Adelaide, Australia
Dr. Kamalesh Venugopal Prevention and population heath
SA Health
Appendix 3 – About the author
Petra E. Verburg was born on the 21st of October 1987 in Piaam, the Netherlands. She went to primary school at Basisschool de Ark in Makkum and to secondary school at Christelijke Scholen Gemeenschap Bogerman in Sneek. She graduated pre-university education in 2006.
After moving to Groningen, she attended Medical School in 2006 at the Rijksuniversiteit Groningen in Groningen, The Netherlands. In 2010 she finished her Bachelor degree. After a short break, she continued her Master degree in Medicine in Groningen. The second year of her clinical rotations she was located at Medisch Centrum Leeuwarden in Leeuwarden. She finished her second year with a social clinical rotation in Paramaribo, Surinam. In 2013, during her final year, she travelled to Adelaide, Australia for a research elective of 6 months at the Epidemiology branch of South Australia Health and Robinson Research Institute of the University of Adelaide. She was supervised by Professors Jan Jaap H.M. Erwich, Gustaaf A. Dekker and Claire T. Roberts. She returned to the Netherlands in November 2013. After her pre-registration clinical rotation, at the Department of Obstetrics and Gynaecology and the Department of Urology at Medisch Centrum Leeuwarden in Leeuwarden, The Netherlands, she graduated Medical school in April 2014.
Between April 2014 and March 2015 she worked at the Department of Obstetrics and Gynaecology at the Universitair Medisch Centrum Groningen, The Netherlands, in preparation to her PhD-project.
Partly self-funded she returned to Adelaide in 2015. Since March 2015 she coordinated and collected data for the Screening Tests to predict poor Outcomes of Pregnancy (STOP) study. Additionally, she was involved in several smaller studies, successfully supervised eight research students and was involved in several research focus groups, whilst working on her PhD.
In April 2018 she returned to The Netherlands and moved to Arnhem, and decided to combine her research career with clinical work. Currently, she is working as a resident Obstetrics and Gynaecology at the Department of Obstetrics and Gynaecology at Rijnstate Ziekenhuis in Arnhem, The Netherlands.
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Appendix 4 – Track record
Personal information
Name: Pieternella Elisabeth Verburg Preferred name: Petra Verburg
Departments: Department of Obstetrics and Gynaecology University Medical Center Groningen University of Groningen
Groningen, The Netherlands Robinson Research Institute University of Adelaide Adelaide, Australia Adelaide Medical School University of Adelaide Adelaide, Australia Epidemiology Branch
SA Health
Adelaide, Australia PhD period: April 2014 – October 2018 Promotors: Professor Dr. Jan Jaap H.M. Erwich
Professor Dr. Gustaaf A. Dekker Professor Claire T. Roberts
Teaching and Mentoring
Students
2018 Janneke Raidt
University of Groningen, NL
Project: ‘The correlation between intrapartum factors and the likelihood of developing
non-reassuring fetal status’
2017 Eva van der Vlugt
Free University Amsterdam, NL
Project: ‘Predictive factors for small-for-gestational age infants: A sex-specific approach’.
Emily Bliss
University of Adelaide, AUS
Project: Summer school student
José Mollen
University of Groningen, NL
Project: ‘Comparison study of two oscillometric pulse wave analysis devices’.
2016 Mylène Mulder
University of Groningen, NL
Project: ‘Maternal hemodynamic and autonomic function alterations in pregnancies
Katherine Lissner,
University of Adelaide AUS Project: Summer school student
Emma McBean
University of Adelaide, AUS
Project: ‘Maternal haemodynamic changes across gestation and pregnancy outcome’
Michelle Plummer
University of Adelaide, AUS
Project: ‘Pregnancy complications and risk for childhood obesity and vascular impairment’
Honors and Awards
2017
Award Best oral presentation, PSANZ
Travel award, PSANZ
2016
Grant Equipment grant, School of Medicine (AU$ 40.000)
2015
Scholarship PhD Stipend, University of Adelaide, Robinson Research Institute
Grant Travel grant, University of Adelaide, Robinson Research Institute
Research grant, Private sponsor
Award Loke New Investigator Award, IFPA
2014
Scholarship PhD Stipend, University Medical Center Groningen, Department
of Obstetrics and Gynaecology PhD Stipend, University of Groningen
Oranjekliniek Stipend, Nederlandse Vereniging van Obestetrie en Gynaecology (NVOG).
Grant Research grant, Buwalda Stichting
Travel grant, University of Adelaide, Robinson Research Institute Travel grant, University Medical Center Groningen, Department of Obstetrics and Gynaecology
Travel grant, University of Adelaide, Robinson Research Institute
Courses and skills
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Meetings, Conferences and Media
Oct 2018 International Society for the Study of Hypertension in Pregnancy (ISSHP), Amsterdam, NL
Oral: Peripheral maternal haemodynamic state across gestation in pregnancies complicated by hypertensive disorders of pregnancy
Poster: Peripheral maternal haemodynamic gestation across pregnancy in gestational
diabetes mellitus
Apr 2017 Perinatal Society of Australia and New Zealand (PSANZ) Canberra, AUS
Oral: Long-term trends in spontaneous and iatrogenic preterm birth in South Australia. A population-based study 1986-2014.
Nov 2016 Media
Interviews: ‘Seasonality of Gestational Diabetes: A South Australian population study’ resulting in international TV (Channel 7, 9 & 10), radio, written and online media presence.
Nov 2016 Robinson Research Institute Symposium, Adelaide, AUS Jul 2016 Medical Disorders in Pregnancy 2016 Seminar, Melbourne, AUS Jul 2016 Media
Interviews: ‘Sexual dimorphism in adverse pregnancy outcomes - A retrospective Australian population study 1981-2011’ resulting in international TV (Channel 9), radio, written and online media presence.
Jun 2016 Australian Society of Medical Research (ASMR) Annual Conference, Adelaide, AUS May 2016 Second International Congress on Maternal Haemodynamics, Rome, IT
Nov 2015 Robinson Research Institute Symposium, Adelaide AUS
Oral: ‘Opposite trends in seasonality of gestational diabetes mellitus and pregnancy induced hypertensive disorders – A South Australian population study’
Sep 2015 International Federation of Placenta Associations (IFPA), Brisbane, AUS
Poster: ‘Opposite trends in seasonality of gestational diabetes mellitus and pregnancy induced hypertensive disorders – A South Australian population study’
Oct 2015 Media Adelaide, AUS
Interview: ‘International visitor spotlight’, Robinson Research Institute, Annual Report 2015
Aug 2015 Australian and New Zealand Placental Research Association Satellite meeting, Adelaide, AUS
July 2015 Media
Interview: ‘Screening Tests to identify poor Outcomes in Pregnancy (STOP) study’ resulting in newspaper article (The Advertiser).
May 2015 Australian and New Zealand Preeclampsia Research Network meeting, Adelaide, AUS Oct 2014 International Society for the Study of Hypertension in Pregnancy (ISSHP)
New Orleans, USA
Poster: ‘Fetal sex and pregnancy induced hypertensive disorders in South Australia – A retrospective population study 1982-2011’.
Poster: ‘Seasonality of pregnancy inducted hypertensive disorders in South Australia – A retrospective population study 2007-2011’.
Feb 2014 The Society of Maternal-Fetal medicine (SMFM) Annual Meeting, New Orleans, USA
Poster: ‘Seasonality of gestational diabetes mellitus based on date of conception in South Australia – A retrospective population study 1981-2011’.
Other Activities
Professional and Scientific memberships 2018 ANZPRA, IFPA, ASMR, PSANZ 2017 ANZPRA, IFPA, ASMR, PSANZ 2016 ANZPRA, IFPA, ASMR 2015 ANZPRA, IFPA
Referee peer review journals
Appendix 5 – List of publications
Full-text publications
1. Verburg, P.E., Dekker, G.A., Tucker, G., Scheil, W., Erwich J.J.H.M., & Roberts, C.T. (2018). Seasonality
of hypertensive disorders of pregnancy – A South Australian population study. Pregnancy Hypertension, 12, 118-123. http://doi.org/10.1016/j.preghy.2018.04.006
2. Verburg, P.E., Dekker, G.A., Venugopal, K., Scheil, W., Erwich J.J.H.M., Mol, B.W., & Roberts, C.T.(2017).
Long-term Trends in Singleton Preterm Birth in South Australia From 1986 to 2014. Obstetrics & Gynaecology, 131(1). http://doi.org/10.1097/AOG.0000000000002419
3. Verburg, P.E., Tucker, G., Scheil, W., Erwich J.J.H.M., Dekker, G.A., & Roberts, C.T. (2016).
Sexual dimorphism in adverse pregnancy outcomes – A retrospective Australian population study 1981-2011. PLoS ONE, 11(7), 1-17. http://doi.org/10.1371/journal.pone.0158807
4. Verburg, P.E., Tucker, G., Scheil, W., Erwich J.J.H.M., Dekker, G.A., & Roberts, C.T. (2016).
Seasonality of gestational diabetes mellitus: a South Australian population study.
BMJ Open Diabetes Research and Care, 4, e000286. http://doi.org/10.1136/bmjdrc-2016-000286
5. Wilson, R.L., Leviton, A.J., Leemaqz, S.Y., Anderson, P.H., Grieger, J.A., Grzeskowiak, L.E., Verburg, P.E.,
McCowan, L., Dekker, G.A., Bianco-Miotto, T., Roberts, C.T. (2018). Vitamin D levels in an Australian and New Zealand cohort and the association with pregnancy outcome.
BMC Pregnancy and Childbirth, 18, 1-10. http://doi.org/10.1186/s12884-018-1887-x
Conference publications
1. Verburg, P.E., Tucker, G., Scheil, W., Erwich J.J.H.M., Roberts, C.T. & Dekker, G.A. (2015). Opposite
trends in seasonality of gestational diabetes mellitus and pregnancy induced hypertensive disorders – A South Australian population study.
Placenta 09/2015; 36(9):A42. DOI:10.1016/j.placenta.2015.07.312
2. Verburg, P.E., Tucker, G., Scheil, W., Erwich J.J.H.M., Roberts, C.T. & Dekker, G.A. (2015). [177-POS]:
Seasonality of pregnancy induced hypertensive disorders in South Australia - A retrospective population study 2007-2011.
Pregnancy Hypertension 01/2015; 5(1):91. DOI:10.1016/j.preghy.2014.10.183
3. Verburg, P.E., Tucker, G., Scheil, W., Erwich J.J.H.M., Roberts, C.T. & Dekker, G.A. (2015). [213-POS]:
Fetal sex and pregnancy outcomes in south Australia - A retrospective population study 1981-2011. Pregnancy Hypertension 01/2015;5(1):107-8. DOI:10.1016/j.preghy.2014.10.219
4. Verburg, P.E., Tucker, G., Scheil, W., Erwich J.J.H.M., Roberts, C.T. & Dekker, G.A. (2014). 315:
Seasonality of gestational diabetes mellitus based on date of conception in South Australia–a retrospective population study 2006-2011. American Journal of Obstetrics and Gynecology 01/2014; 210(1):S165. OI:10.1016/j.ajog.2013.10.348
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Appendix 6 - Acknowledgements
To my amazing family, friends, supervisors, colleagues and students,
This thesis is only a small reflection of the enormous journey I have been allowed to make in the past 4 years. Not only in terms of research, but also on a personal level, my PhD has had an indelible influence on me. Every day I am grateful for this experience and your indispensable role in my journey. Without you it would not have been the same.
Thank you…
• For having my back • For listening
• For sharing wine and coffees • For your inspiration • For your guidance • For always being there • For your encouragements • For sharing dances • For believing in me • For being who you are I am blessed to have you in my life.
Dankwoord
Aan mijn geweldige familie, vrienden, supervisors, collega’s en studenten,
Dit proefschrift is slechts een kleine weerspiegeling van de enorme reis die ik de afgelopen 4 jaar heb mogen maken. Niet alleen op het gebied van onderzoek, maar ook op persoonlijk niveau heeft mijn doctoraat een onuitwisbare invloed op mij gehad. Ik ben elke dag dankbaar voor deze ervaring en jouw onmisbare rol in mijn reis. Zonder jou zou het niet hetzelfde zijn geweest.
Dank je wel…
• Dat je altijd achter me staat. • Voor het naar me te luisteren • Voor het delen van wijn en koffie • Voor uw/je inspiratie
• Voor uw/je begeleiding
• Voor het er altijd voor me te zijn. • Voor uw/je aanmoedigingen • Voor de dansjes
• Voor het in mij te geloven • Voor het zijn wie je bent Ik ben gezegend met jou in mijn leven.
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Appendix 7 – SHARE theses list
This thesis is published within the Research Institute SHARE (Science in Healthy Ageing and healthcaRE)
of the University Medical Center Groningen / University of Groningen.
Further information regarding the institute and its research can be obtained from our internet site: http://www.share.umcg.nl/
More recent theses can be found in the list below ((co-) supervisors are between brackets).
2018
Miranda Azevedo R de
Shades of blue; an epidemiological investigation of depressive symptom dimensions and the association with cardiovascular disease
(prof P de Jonge, dr AM Roest)
Pang C
Computational methods for data discovery, harmonization and integration; using lexical and semantic matching with an application to biobanking phenotypes
(prof MA Swertz, prof JL Hillege)
Arifin B
Distress and health-related quality of life in Indonesian Type 2 diabetes mellitus outpatients (prof MJ Postma, dr PJM Krabbe, dr J Atthobari)
Zakiyah N
Women’s health from a global economic perspective (prof MJ Postma, dr ADI van Asselt)
Metting, EI
Development of patient centered management of asthma and COPD in primary care (prof T van der Molen, prof R Sanderman, dr JWH Kocks)
Scheffers WJ
Body experience in patients with mental disorders
(prof RA Schoevers, dr JT van Busschbach, dr MAJ van Duijn)
Suhoyo Y
Feedback during clerkships: the role of culture
(prof JBM Kuks, prof J Cohen-Schotanus, dr J Schönrock-Adema)
Kikkert LHJ
Gait characteristics as indicators of cognitive impairment in geriatric patients (prof T Hortobagyi, dr CJ Lamoth, dr N Vuillerme)
Veen HC van der
Articulation issues in total hip arthroplasty
(prof SK Bulstra, dr JJAM van Raay, dr IHF Reininga, dr I van den Akker-Scheek)
Elsenburg LK
Adverse life events and overweight in childhood, adolescence and young adulthood (prof AC Liefbroer, dr N Smidt)
Becking K
Inflammatory matters; exploring the underlying pathophysiology of unipolar and bipolar disorder (prof RA Schoevers, dr BCM Haarman)
‘t Hoen EFM
Practical applications of the flexibilities of the agreement on trade-related aspects of intellectual property rights; lessons beyond HIV for access to new essential medicines
(prof HV Hogerzeil, prof BCA Toebes)
Stojanovska V
Fetal programming in pregnancy-associated disorders; studies in novel preclinical models (prof SA Scherjon, dr T Plösch)
Eersel MEA van
The association of cognitive performance with vascular risk factors across adult life span (prof JPJ Slaets, dr GJ Izaks, dr JMH Joosten)
Rolfes L
Patient participation in pharmacovigilance
(prof EP van Puijenbroek, prof K Taxis, dr FPAM van Hunsel)
Brandenbarg D
The role of the general practitioner in the care for patients with colorectal cancer (prof MY Berger, prof GH de Bock, dr AJ Berendsen)
Oldenkamp M
Caregiving experiences of informal caregivers; the importance of characteristics of the informal caregiver, care recipient, and care situation
(prof RP Stolk, prof M Hagedoorn, prof RPM Wittek, dr N Smidt)
Kammen K van
Neuromuscular control of Lokomat guided gait; evaluation of training parameters (prof LHV van der Woude, dr A den Otter, dr AM Boonstra, dr HA Reinders-Messelink)
Hornman J
Stability of development and behavior of preterm children (prof SA Reijneveld, prof AF Bos, dr A de Winter)
Vries, YA de
Evidence-b(i)ased psychiatry (prof P de Jonge, dr AM Roest)
Smits KPJ
Quality of prescribing in chronic kidney disease and type 2 diabetes (prof P denig, prof GJ Navis, prof HJG Bilo, dr GA Sidorenkov)
