Cover Page
The handle
http://hdl.handle.net/1887/136912
holds various files of this Leiden University
dissertation.
Author: Barnhoorn, M.C.
Title: Stromal cells in inflammatory bowel disease : perspectives of local mesenchymal
stromal cell therapy
Copyright © 2020 Marieke Barnhoorn. All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any way or by any means without the prior permission of the author, or when applicable, of the publishers of the scientific papers.
ISBN: 978-94-6380-760-9
Design and Lay-out: Vera van Ommeren, persoonlijkproefschrift.nl Printing: ProefschriftMaken
Cover: Fart in the wind, Do Ho Suh
Stromal cells in Inflammatory Bowel Disease
Perspectives of local mesenchymal stromal cell therapy
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties, te verdedigen op donderdag 7 mei 2020
klokke 15:00 uur
Door
Promotor: Prof. dr. ir. H.W. Verspaget Co-promotores: Dr. A.E. van der Meulen-de Jong
Dr. L.J.A.C. Hawinkels Promotiecommissie: Prof. dr. J.J. Zwaginga
Prof. dr. C.J. van der Woude (Erasmus MC)
TABLE OF CONTENTS
Chapter 1 General introduction 9
Chapter 2 Stromal cells in the pathogenesis of inflammatory bowel disease 21
Chapter 3 Immunoregulatory role of fibroblasts derived from Crohn’s disease
associated perianal fistulas. 57
Chapter 4 Long-term evaluation of allogeneic bone marrow-derived
mesenchymal stromal cells for treatment of Crohn’s disease perianal fistulas
85
Chapter 5 Lymphoproliferative disease in the rectum 4 years after local mesenchymal stromal cell therapy for refractory perianal Crohn’s fistulas: a case report
101
Chapter 6 Intraluminal injection of mesenchymal stromal cells in spheroids
attenuates experimental colitis 113
Chapter 7 Endoscopic administration of mesenchymal stromal cells reduce
inflammation in experimental colitis 141
Chapter 8 Mesenchymal stromal cell-derived exosomes contribute to epithelial regeneration in experimental inflammatory bowel disease 167 Chapter 9 The local cytokine milieu in patients with inflammatory bowel disease
impacts phenotype and function of mesenchymal stromal cells 185
Chapter 10 Summarizing discussion 215
Appendix Nederlandse samenvatting 234
List of publications 238
Curriculum vitae 239
