Citation
Plug, I. (2005, September 6). Hemophilia on the treshold of the 21st century. Retrieved from https://hdl.handle.net/1887/3389
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in theInstitutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/3389
Hemophilia on the threshold of the 21
stcentury
Novo Nordisk Farma B.V., Sanquin, W yeth Pharmaceuticals and ZLB Behring generously provided support for the printing of this thesis.
Cover design: Painting by Arie M euldijk, 1991 Printed by: Optima Grafische Communicatie Lay out: Yvonne Souverein
Hemophilia on the threshold of the 21
stcentury
PROEFSCHRIFT
t
er
verkri
j
gi
ng
van
de
graad
van
Doct
or
aan
de
Uni
versi
t
ei
t
Lei
den
op
gezag
van
Rect
or
M agni
fi
cus
Dr.
D.
D.
Brei
mer
hoogl
eraar
i
n
de
facul
t
ei
t
der
W i
skunde
en
Nat
uurwet
enschappen
en
di
e
der
Geneeskunde,
vol
gens
besl
ui
t
van
het
Col
l
ege
voor
Promot
i
es
t
e
verdedi
gen
op
di
nsdag
6
sept
ember
2005
t
er
kl
okke
14.
15
uur
door
Iri
s
Pl
ug
geboren
t
e
Geervl
i
et
Co-promotor: Dr J.G. van der Bom
Referent: Prof. dr E. Briët (Sanquin) Overige leden: Prof. dr J.P. Vandenbroucke
The most exciting phrase to hear in science, the one that heralds new discoveries, is not 'Eureka!', but 'That's funny...'
Isaak Asimov
7
Table of contents
Chapter 1
General introduction 11
Chapter 2
Outcome and side effects of treatment of hemophilia
2.1 M ortality and causes of death in patients with hemophilia,1992-2001 19 2.2 Thirty years of hemophilia treatmentin the Netherlands,1972-2001 39
2.3 Socialfunctioning of patients with hemophilia 65
2.4 Hepatitis C infection among Dutch hemophilia patients:a nationwide
cross-sectionalstudy into prevalence and antiviraltreatment 81
2.5 The uptake of recombinantfactor VIII in the Netherlands 99
Chapter 3
Female carriers of hemophilia
3.1 Bleeding in carriers of hemophilia 127
General Discussion 145
Summary 157
Samenvatting 163
Nawoord 169
