Cover Page
The handle http://hdl.handle.net/1887/123227 holds various files of this Leiden University dissertation.
Author: Maurits, E.
Targeting Human Proteasomes:
Substrates, Inhibitors and Prodrugs
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op 7 juli 2020
klokke 11:15 uur
door
Elmer Maurits
Promotiecommisie
Promotor : Prof. dr. H. S. Overkleeft
Co-promotor : Dr. S. I. van Kasteren Dr. B.I. Florea
Overige leden : Prof. dr. M. van der Stelt Prof. dr. G. A. van der Marel Dr. E. Huber
Dr. K. M. Bonger
Table of contents
Chapter 1 7
General introduction
Chapter 2 17
Structure-based design of fluorogenic substrates selective for human proteasome subunits
Chapter 3 41
Oligopeptide-masked doxorubicins for in situ immunoproteasome-mediated activation
Chapter 4 75
Immunoproteasome inhibitor-doxorubicin conjugates target multiple myeloma cells and release doxorubicin upon low-dose photon irradiation
Chapter 5 89
Chapter 6 111
Structure-based design of pan-immuno selective proteasome inhibitors
Chapter 7 155
Summary and future prospects
Nederlandse Samenvatting 171
List of publications 175
Curriculum Vitae 177
