Cover Page
The handle http://hdl.handle.net/1887/45008 holds various files of this Leiden University dissertation
Author: Sala, Michiel
Title: MR and CT evaluation of cardiovascular risk in metabolic syndrome Issue Date: 2016-12-14
MR AND CT EVALUATION OF CARDIOVASCULAR RISK IN METABOLIC SYNDROME
Michiel Lodewijk Sala
Cover design and layout: Jardine Media, www.jardinemedia.com Printing: Ridderprint B.V., www.ridderprint.nl
ISBN: 978-94-6299-483-6
The cover shows Portrait of a Gentleman by Charles Mellin (1597-1649), who painted it around 1630. The person portrayed is possibly Alessandro del Borro, a Tuscan general. By courtesy of Gemäldegalerie, Staatliche Musee zu Berlin. Reproduced with permission.
© Copyright 2016, M.L. Sala, The Hague, The Netherlands
The copyright of the articles that have been published has been transferred to the respective journals. No parts of this thesis may be reproduced or transmitted in any form, by any means, without prior permission of the author.
MR AND CT EVALUATION OF CARDIOVASCULAR RISK IN METABOLIC SYNDROME
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens het besluit van het College voor Promoties te verdedigen op woensdag 14 december 2016
klokke 11.15 uur
door
Michiel Lodewijk Sala
geboren te Utrecht in 1985
PROMOTIECOMMISSIE
Promotor: Prof. dr. A. de Roos
Co-promotores: Dr. L.J.M. Kroft
Dr. J. Van der Grond
Overige leden: Prof. dr. ir. B.P.F. Lelieveldt
Prof. dr. M.V. Huisman
Prof. dr. T. Leiner (UMC Utrecht)
Dr. B.K. Velthuis (UMC Utrecht)
Prof. dr. W.H. Backes (Maastricht UMC)
Aan mijn ouders
TABLE OF CONTENTS
CHAPTER 1 General introduction and outline of the thesis 9
CHAPTER 2 Genetically determined prospect to become long-lived is associated with less abdominal fat and in particular less abdominal visceral fat in men
Sala ML, Roell B, van der Bijl, et al. Age and Ageing 2015 Jul;44(4):713-7
17
CHAPTER 3 Association of liver enzymes and computed tomography markers of liver steatosis with familial longevity
Sala ML, Kroft LJ, Roell B, et al. PLoS One, 2014 Mar14;9(3)e91085
29
CHAPTER 4 Liver fat assessed with CT relates to MRI markers of incipient brain injury in middle-aged to elderly persons with overweight Sala ML, van der Grond J, van Heemst D, et al. AJR Am J Roentgenol 2016 May 21;206(5):1087-92
49
CHAPTER 5 Aortic arch stiffness is associated with incipient brain injury in patients with hypertension
Sala ML, van den Berg-Huysmans A, van der Grond J, et al. Am J Hypertens 2016 Jun;29(6):705-12
65
CHAPTER 6 Microstructural brain tissue damage in metabolic syndrome
Sala ML, de Roos A, van den Berg-Huysmans A, et al. Diabetes Care 2014 Feb;37(2):493-500
83
CHAPTER 7 Association between changes in brain microstructure and cognition in older subjects at increased risk for vascular disease
Sala ML, de Roos A, Blauw GJ, et al. BMC Neurol 2015 Aug 7;15:133
101
CHAPTER 8 The effect of temporal resolution on the accuracy of aortic arch pulse wave velocity from velocity-encoded magnetic resonance imaging
Sala ML, de Roos A, van den Boogaard P, et al. Submitted
117
Summary and conclusions Nederlandse samenvatting en conclusies List of publications
Curriculum Vitae Dankwoord
133 137 143 145 147
