Cover Page The handle

Cover Page

The handle http://hdl.handle.net/1887/19855 holds various files of this Leiden University dissertation.

Author: Solingen, Coen van

Title: The role of microRNA-126 in vascular homeostasis Date: 2012-09-26



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migration compared to control (%)

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addition SDF-1 vehicle scram anta- 126

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% %

scr anta-126 0

1 2 3 4 5

Sca+/Lin- cells per Lin+ leukocytes (%)

P<0.05

scr anta-126 0

5 10 15

white blood cells (106/mL) P<0.01

scr anta-126 0.0

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P=0.19

scr

scr anta-126anta 126 0.0

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SDF-1 (ng/mL)

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progenitor cell mobilization and adhesion viable endothelium

SPRED-1 PI3KR2

VEGFR

angiogenesis survival

miR-126

SDF-1

dysfunctional endothelium

SPRED-1 PI3KR2 VEGFR

miR-126

SDF-1 VCAM-1 VCAM-1



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QEVVS[HIVMZIHGIPPW&PSSH

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JVSQ YQFMPMGEP ZIMRW -HIRXM½GEXMSR F] QSVTLSPSKMG ERH MQQYRSPSKMG GVMXIVME . 'PMR -RZIWX



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EP:EWGYPEV IRHSXLIPMEP KVS[XL JEGXSV SZIVI\TVIWWMSR MR MWGLIQMG WOIPIXEP QYWGPI IRLERGIW

Q]SKPSFMRI\TVIWWMSRMRZMZS'MVG6IW

 (IZMRI 71:MN 6 6IXXMK 18SHX 0 1G+PEYGLPIR / *MWLIV 2 IX EP 6ETMH QSFMPM^EXMSR SJ

JYRGXMSREPHSRSVLIQEXSTSMIXMGGIPPW[MXLSYX+'7*YWMRK%1(ERERXEKSRMWXSJXLI

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GVS62%F]ETSTXSXMGFSHMIWMRHYGIW'<'0HITIRHIRXZEWGYPEVTVSXIGXMSR7GM7MKREP

VE

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MRKQMGVS62%WEWWXEFPIFPSSHFEWIHQEVOIVWJSVGERGIVHIXIGXMSR4VSG2EXP%GEH7GM97%



 0E[VMI',+EP7(YRPST,14YWLOEVER&0MKKMRW%44YPJSVH/IXEP(IXIGXMSRSJIPIZEXIH

PIZIPW SJ XYQSYVEWWSGMEXIH QMGVS62%W MR WIVYQ SJ TEXMIRXW [MXL HMJJYWI PEVKI &GIPP P]Q

TLSQE&V.,EIQEXSP

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 'SVWXIR1*(IRRIVX6.SGLIQW7/Y^RIXWSZE8(IZEY\=,SJWXVE0IXEP'MVGYPEXMRK1M

GVS62%FERH1MGVS62%VI¾IGXQ]SGEVHMEPHEQEKIMRGEVHMSZEWGYPEVHMWIEWI'MVG



'EVHMSZEWG+IRIX

 %M.>LERK60M=4Y.0Y=.MES.IXEP'MVGYPEXMRKQMGVS62%EWETSXIRXMEPRSZIPFMSQEVOIV

JSVEGYXIQ]SGEVHMEPMRJEVGXMSR&MSGLIQ&MSTL]W6IW'SQQYR

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EKYPERX.'PMR-RZIWX

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