MRI evaluation of end-organ damage in diabetes and hypertension
Elderen, S.G.C. van
Citation
Elderen, S. G. C. van. (2010, December 21). MRI evaluation of end-organ damage in diabetes and hypertension. Retrieved from
https://hdl.handle.net/1887/16265
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License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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MRI evaluation of end-organ damage, in Diabetes and Hypertension
Saskia Gerdina Cornelia van Elderen
2010
Printed by: Optima Grafi sche Communicatie, Rotterdam
ISBN/EAN: 978-90-9025758-7
© 2010, S.G.C. van Elderen, Leiden, The Netherlands. All rights reserved. No part of this thesis may be reproduced or transmitted in any form, by any means, without prior written permis- sion of the author.
MRI evaluation of end-organ damage, in Diabetes and Hypertension
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnifi cus Prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 21 december 2010
klokke 15.00 uur
door
Saskia Gerdina Cornelia van Elderen
geboren te Eindhoven in 1982
PROMOTIECOMMISSIE
Promotores Prof. Dr. A. de Roos Prof. Dr. J.W.A. Smit
Co-promotores Dr. ir. J.J.M. Westenberg Dr. J. van der Grond
Overige commissieleden Prof. Dr. M.A. van Buchem Prof. Dr. A.G. Webb Dr. L.J.M. Kroft
The research described in this thesis was carried out at the department of Radiology (head:
Prof. dr. J.L. Bloem) and Endocrinology (head: Prof. dr. J.W.A. Smit) of the Leiden University Medical Center.
Financial support by the Netherlands Heart Foundation and the Dutch Diabetes Foundation for the publication of this thesis is gratefully acknowledged. Additional fi nancial support is provided by The J.E. Jurriaanse Foundation, Foundation Imago Oegstgeest, Foundation of Image Processing, Philips Healthcare Benelux, Novo Nordisk BV, Boehringer Ingelheim BV, Toshiba Medical Systems Nederland, Guerbet Nederland BV, Philips Healthcare Nederland, Eli Lilly Nederland BV, and Servier Nederland Farma BV.
Aan mijn ouders
Contents
Chapter 1 General introduction and outline 9
Part I: Evaluation of end-organ damage by standardized MR imaging tests, in Diabetes and Hypertension
Chapter 2 The eff ect of hypertension on aortic pulse wave velocity in type 1 diabetes mellitus patients: assessment by MR imaging
19
Submitted
Chapter 3 Association of aortic arch pulse wave velocity with left ventricular mass and lacunar brain infarcts in hypertensive patients: assessment by MR imaging
31
Radiology 2009:253(3):681-688
Chapter 4 Aortic stiff ness is associated with cardiac function and cerebral small vessel disease in patients with type 1 diabetes mellitus: assessment by MR imaging
47
European Radiology 2010:20(5):1132-1138
Chapter 5 Increased aortic stiff ness measured by MR imaging in type 1 diabetes mellitus patients and the relationship with renal function
61
American Journal of Roentgenology, accepted 2010
Chapter 6 Cerebral perfusion and aortic stiff ness are independent predictors of white matter brain atrophy in type 1 diabetes mellitus patients:
assessment by MR imaging
73
Submitted
Chapter 7 Progression of brain atrophy and cognitive decline in diabetes mellitus, a 3 year follow-up
85
Neurology 2010:75(11):997-1002
Part II: Innovative MR techniques
Chapter 8 Phosphorus-31 MR spectroscopy of skeletal muscle in maternally inherited diabetes and deafness A3243G mitochondrial mutation carriers
99
Journal of Magnetic Resonance Imaging 2009:29(1):127-131
Chapter 9 Initial results on in vivo human coronary MR angiography at 7 Tesla 111 Magnetic Resonance in Medicine 2009:62(6):1379-1384
Chapter 10 Right coronary MR angiography at 7 Tesla: a direct quantitative comparison with 3 Tesla in young healthy volunteers
125
Radiology 2010:257(1):254-259
Summary and conclusions 137
Samenvatting en conclusies 143
List of publications 151
Dankwoord 157
Curriculum vitae 161
