Citation
Visser, Y. P. de. (2011, June 14). Intervention studies in a rat model of bronchopulmonary dysplasia : effects on cardiopulmonary injury and lung development. Retrieved from https://hdl.handle.net/1887/17705
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/17705
Note: To cite this publication please use the final published version (if applicable).
Intervention studies in a rat model of bronchopulmonary dysplasia
Effects on cardiopulmonary injury and lung development
Yvonne P. de Visser
Intervention studies in a rat model of bronchopulmonary dysplasia
Effects on cardiopulmonary injury and lung development
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op 14 juni 2011
klokke 16:15 uur
door
Yvonne Petronella de Visser geboren te Emmeloord in 1981
Prof. dr. L.J.I. Zimmermann
Prof. dr. H.A. Delemarre-van de Waal
Copyright © 2011 Y.P. de Visser
All rights reserved. No part of this publication may be reproduced in any form or by any means, by print, photocopy, electronically or any other means without permission of the author.
ISBN: 978-90-8891-292-4
Cover illustration: Inverted picture of von Willebrand Factor immunohistochemistry on lung tissue of a neonatal rat pup at 10 days of age
Cover design by Yvonne de Visser and Boxpress BV.
Printed by: Boxpress BV / Proefschriftmaken.nl – Oisterwijk, The Netherlands
The research presented in this thesis was performed at the Department of Pediatrics, Laboratory of Neonatology, Leiden University Medical Center, The Netherlands
Publication of this thesis was financially supported by the Willem-Alexander Children’s Hospital of the Leiden University Medical Center, Nycomed GmbH, Konstanz, Germany and the Netherlands Heart Foundation
“Men kan evengoed dromen zonder te slapen als slapen zonder te dromen.”
G.C. Lichtenberg (1742-1799)
Voor Pap en Mam
Table of Contents
Chapter 1 General introduction and Outline of the thesis 9 Chapter 2 Phosphodiesterase-4 inhibition attenuates pulmonary inflammation 33
in neonatal lung injury.
Eur Respir J. 2008; 31(3):633-44.
Chapter 3 Phosphodiesterase-4-inhibition attenuates heart and lung injury 57 by perinatal hyperoxia in neonatal and adult rats.
Submitted to Am J Physiol Lung Cell Mol Physiol 2011.
Chapter 4 Sildenafil attenuates pulmonary inflammation and fibrin 85 deposition, mortality and right ventricular hypertrophy in neonatal hyperoxic lung injury.
Respir Res. 2009; 10:30.
Chapter 5 Apelin attenuates hyperoxic lung and heart injury in neonatal rats. 111 Am J Respir Crit Care Med. 2010;182(10):1239-50.
Chapter 6 Allogenic stem cell therapy improves right ventricular function by 147 improving lung pathology in rats with pulmonary hypertension.
Am J Physiol Heart Circ Physiol. 2009; 297(5):H1606-16.
Chapter 7 General discussion 171
Chapter 8 Summary 183
Summary in Dutch (Samenvatting)
Curriculum Vitae 191
List of publications 193
