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University of Groningen PET imaging and in silico analyses to support personalized treatment in oncology Moek, Kirsten

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University of Groningen

PET imaging and in silico analyses to support personalized treatment in oncology

Moek, Kirsten

DOI:

10.33612/diss.112978295

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Moek, K. (2020). PET imaging and in silico analyses to support personalized treatment in oncology.

Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.112978295

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Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

(2)

Stellingen behorende bij het proefschrift

PET imaging and in silico analyses to support personalized

treatment in oncology

1. PET imaging met radioactief gelabelde antilichamen kan geneesmiddelenontwikkeling en therapiebeslissingen ondersteunen (dit proefschrift).

2. Een microdosis 89Zr-AMG 211 PET kan 89Zr-AMG 211 opname in organen en tumorlaesies

visualiseren en kwantificeren (dit proefschrift).

3. Glypican 3 komt tot expressie in de helft van de plaveiselcellongcarcinomen en vormt derhalve een potentieel drugtarget (dit proefschrift).

4. Functional genomic mRNA profiling is een tool om drugtargets te identificeren voor zowel frequent gediagnosticeerde als zeldzame tumor types (dit proefschrift).

5. Human epidermal growth factor 2 (HER2) is het meest gebruikte target voor antibody-drug conjugaten (dit proefschrift).

6. BiTE antilichamen kunnen óók bijdragen aan de behandeling van solide tumoren (Hummel et al. J Clin Oncol 2019, abstract 5034).

7. Bij bispecifieke antilichamen kan profylactisch gebruik van TNFα blokkers het cytokine release syndroom voorkomen, zonder dat de therapeutische effectiviteit van de

oncologische behandeling in het geding komt (Li et al. Sci Transl Med 2019).

8. Anti-PD-1 of anti-PD-L1 antilichamen kunnen zowel pseudoprogressie als hyperprogressie induceren (Ferrara et al. JAMA Oncol 2018).

9. Ter preventie van Pneumocystis jiroveni dient antibiotica profylaxe te worden voorgeschreven aan patiënten die tenminste 4 weken worden behandeld met prednison ≥ 30 mg/dag (Park

et al. Ann Rheum Dis 2018).

10. Iedere volwassene ≥ 50 jaar dient gevaccineerd te worden tegen herpes zoster (Lal et al. N Engl J Med 2015).

11. “Everybody is a genius. But if you judge a fish by its ability to climb a tree, it will live its whole life believing that it is stupid” (Albert Einstein).

12. “It is far more important to know what person the disease has than what disease the person has” (Hippocrates).

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