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University of Groningen Pulmonary Nodules: 2D versus 3D evaluation in lung cancer screening Han, Daiwei

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University of Groningen

Pulmonary Nodules: 2D versus 3D evaluation in lung cancer screening

Han, Daiwei

DOI:

10.33612/diss.172563513

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2021

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Han, D. (2021). Pulmonary Nodules: 2D versus 3D evaluation in lung cancer screening. University of Groningen. https://doi.org/10.33612/diss.172563513

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Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

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559233-l-bw-Han 559233-l-bw-Han 559233-l-bw-Han 559233-l-bw-Han Processed on: 20-5-2021 Processed on: 20-5-2021 Processed on: 20-5-2021

Processed on: 20-5-2021 PDF page: 1PDF page: 1PDF page: 1PDF page: 1

Pulmonary nodules:

2D versus 3D evaluation in lung cancer screening

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559233-l-bw-Han 559233-l-bw-Han 559233-l-bw-Han 559233-l-bw-Han Processed on: 20-5-2021 Processed on: 20-5-2021 Processed on: 20-5-2021

Processed on: 20-5-2021 PDF page: 2PDF page: 2PDF page: 2PDF page: 2 Cover design by Ilse Modder | www.ilsemodder.nl

Layout by Ilse Modder | www.ilsemodder.nl Printed by Gildeprint, Enschede | www.gildeprint.nl

ISBN: 978-94-6419-219-3

The publication of this thesis was financially supported by University of Groningen, University Medical Center Groningen

Copyright © 2021 by Dawei Han.

All rights reserved. Any unauthorised reprint or use of this material is prohibited. No part of this thesis may be reproduced, stored or transmitted in any form or by any means, without written permission of the copyright owner.

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559233-l-bw-Han 559233-l-bw-Han 559233-l-bw-Han 559233-l-bw-Han Processed on: 20-5-2021 Processed on: 20-5-2021 Processed on: 20-5-2021

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Pulmonary nodules: 2D versus 3D

evaluation in lung cancer screening

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the Rector Magnificus Prof. C. Wijmenga

and in accordance with the decision by the College of Deans. This thesis will be defended in public on

Tuesday 29 June 2021 at 9.00 hours

by

Daiwei Han

born on 11 July 1991 in Wuhan, China

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559233-l-bw-Han 559233-l-bw-Han 559233-l-bw-Han 559233-l-bw-Han Processed on: 20-5-2021 Processed on: 20-5-2021 Processed on: 20-5-2021

Processed on: 20-5-2021 PDF page: 4PDF page: 4PDF page: 4PDF page: 4 Supervisors Prof. R. Vliegenthart Prof. M. Oudkerk Co-supervisor Dr. M.A. Heuvelmans Assessment Committee Prof. D.J. Slebos Prof. R.N.J. Veldhuis Prof. P.A. De Jong

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559233-l-bw-Han 559233-l-bw-Han 559233-l-bw-Han 559233-l-bw-Han Processed on: 20-5-2021 Processed on: 20-5-2021 Processed on: 20-5-2021

Processed on: 20-5-2021 PDF page: 5PDF page: 5PDF page: 5PDF page: 5

CONTENTS

Chapter 1 General introduction

PART I 2D versus 3D assessment of pulmonary nodules in lung

cancer screening

Chapter 2 Update on European lung cancer screening trials and comparison of screening recommendations.

Chapter 3 Volume versus diameter assessment of small pulmonary nodules in CT lung cancer screening.

Chapter 4 Influence of nodule margin on volume- and diameter-based reader variability in CT lung cancer screening.

Chapter 5 Detection and size quantification of pulmonary nodules in ultralow-dose versus regular-dose CT: a comparative study in COPD patients

PART II Classification of perifissural nodules

Chapter 6 New fissure-attached nodules in lung cancer screening: a brief report from the NELSON study

Chapter 7 Response letter on the editorial “New fissure-attached nodules in lung cancer screening: more practical implications from the NELSON study?”

Chapter 8 Evaluation of a Novel Deep Learning-Based Classifier for Perifissural Nodules

PART III  General discussion and summary

Chapter 9 General discussion Chapter 10 Summary

Addendum Nederlandse samenvatting (Summary in Dutch) List of publications

Acknowledgments About the author

9 17 19 37 57 77 95 97 111 117 135 137 151 157 162 164 166

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