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University of Groningen

Improving treatment and imaging in ADPKD

van Gastel, Maatje Dirkje Adriana

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

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Publication date: 2019

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

van Gastel, M. D. A. (2019). Improving treatment and imaging in ADPKD. Rijksuniversiteit Groningen.

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S T E L L I N G E N / P R O P O S I T I O N S

1. Lifestyle advice with high water and low sodium intake should be prescribed to ameliorate disease progression in patients with ADPKD – this thesis 2. Plasma copeptin concentration and change in copeptin help to predict which patient with ADPKD will benefit from tolvaptan treatment – this thesis 3. Polyuria due to tolvaptan use is treatable and is no reason to refrain from prescribing this drug – this thesis

4. A reduction in dietary sodium intake lowers the aquaretic side-effects of tolvaptan and should be adviced to patients – this thesis

5. T2 weighted magnetic resonance images (MRIs) are superior to T1 weighted MRIs for kidney volume assessment in ADPKD – this thesis 6. The gold standard for assessment of kidney volume in ADPKD, manual tracing, will soon be outdated – this thesis

7. There are two objects of medical education: To heal the sick, and to ad vance the science – Charles H. Mayo, founder of Mayo Clinic

8. Logic will get you from A to B. Imagination will take you everywhere – Albert Einstein

9. When people are determined they can overcome anything – Nelson Mandela 10. The place you are born should not determine your chances in life.

Further degradation of regulations that secure equal opportunities for, among others education, should thus be prevented

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